VEGF-A
Endostatin inhibits VEGF A induced osteoclastic bone resorption in vitro
... of VEGF-A-stimulated resorption in the endostatin treated pit ...the VEGF-A-induced osteoclast ...blocked VEGF-induced ERK1/2 phosphoryla- tion in immortalized human chondrocytes (C28/I2) ...
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VEGF A165b protects against proteinuria in a mouse model with progressive depletion of all endogenous VEGF A splice isoforms from the kidney
... othelial cell expression, as demonstrated by an increase in PECAM-1 and VEGFR2, and glomerular capillary circumference (Fig. 5). Although we did not observe any changes in the expression of VEGFR2 using immuno- ...
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The Different Impact of VEGF-A and VEGF-D on Peritumoral Brain Edema
... both VEGF-dependent and VEGF-independent pathways of edema production in gliomas and may explain whye demais not reduced in some patients following anti-VEGF treatment ...of VEGF-A in brain ...
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Role of VEGF-A in angiogenesis promoted by umbilical cord-derived mesenchymal stromal/stem cells: in vitro study
... of VEGF-A by UC-MSCs derived from Wharton jelly may be related to the unusual structure of loose connective tissue forming Wharton jelly, and, in particular, the lack of blood capillaries in ...soluble ...
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VEGF - A Precis’
... angiogenesis. VEGF shot to prominence in research in the past score of years but there have been earlier reports that have had a seminal impact on the run-up to its discovery and extensive ...the VEGF ...
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Original Article Overexpression of both VEGF-A and VEGF-C in gastric cancer correlates with prognosis, and silencing of both is effective to inhibit cancer growth
... of VEGF-A and VEGF-C may reduce cancer growth, progression and lym- phatic ...either VEGF-A or VEGF-C in the biological behaviors of ...both VEGF-A and VEGF-C, who present with ...
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VEGF: a critical player in neurodegeneration
... than VEGF — this molecule has been implicated in vir- tually every type of angiogenic disorder, including those associated with cancer, ischemia, and inflamma- tion ...that VEGF is also involved in ...of ...
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Immunohistochemical Study of Differential Expression of VEGF - A in the Normal Placenta and its Association with Fetal and Placental Parameters in Term Pregnancy
... Vascular Endothelial Growth Factor (VEGF) is a key molecule in the development of vessels in the placenta. In early pregnancy, it helps in implantation, development of vessels in the villi of placenta and ...
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1,2-Dioleoyl-3-Trimethylammonium-Propane (DOTAP)-Formulated, Immune-Stimulatory Vascular Endothelial Growth Factor A Small Interfering RNA (siRNA) Increases Antitumoral Efficacy in Murine Orthotopic Hepatocellular Carcinoma with Liver Fibrosis
... via VEGF-A silencing, with or without 1,2-dioleoyl-3-trimethylammonium- propane (DOTAP; cationic lipid) formulation, in HCC mice with preexisting liver ...naked VEGF-A small interfering RNA (siRNA; 200 ...
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Pazopanib and anti-VEGF therapy
... Interestingly, VEGF-A binds VEGFR1 with higher affinity than VEGFR2, although activation of VEGFR2 results in greater phosphory- lation and downstream ...ligand, VEGF-C, ...
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Genetic variants of VEGFR-1 gene promoter in acute myocardial infarction
... Human VEGFR-1 gene has been localized to chromo- some 13p12 and encodes two isoforms: a full length transmembrane VEGFR-1/Flt-1, and soluble VEGFR-1 (sVEGFR-1/sFlt-1). While expression of transmembrane VEGFR-1 and ...
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Investigation of VEGF and PDGF signals in vascular formation by 3D culture models using mouse ES cells
... Although VEGF had never been added to the culture medium of the PDGF B group, the mRNA of Vegf a was higher in the PDGF B group than that of ...by VEGF, vessels in PDGF B were able to produce ...
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The association of angiogenic factors and chronic kidney disease
... of VEGF-A ...Plasma VEGF-A, sVEGFR-1, VEGFR-2, and angiopoietin-1 were measured using a sand- wich immunoassay on a Meso Scale Discovery Instrument (Meso Scale Diagnostics, ...for VEGF-A, ...
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PREDICTIVE VALUE OF VASCULAR ENDOTHELIAL GROWTH FACTOR IN WOMEN UNDERGOING INTRACYTOPLASMIC SPERM INJECTION WITH HIGH RISK FOR OVARIAN HYPERSTIMULATION SYNDROME
... of VEGF receptors. In some studies, the gap between VEGF and receptors is necessary for developing OHSS, and the VEGFR-2 inhibitor, like the dopamine agonist, can reverse hCG action on vascular ...
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Obesity-associated insulin resistance is correlated to adipose tissue vascular endothelial growth factors and metalloproteinase levels
... [15]. VEGF-A (17- 23 kDa) is a major angiogenic factor that stimulates pro- liferation and migration of ECs ...[16]. VEGF-B (21 kDa) is 43% identical to VEGF-A; it also promotes angiogenesis and is ...
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Review Article Molecular mechanisms of lymphatic metastasis in solid tumors of the gastrointestinal tract
... members VEGF-A, VEGF-B, VEGF-C, VEGF-D, PIGF, three tyrosine kinase receptors VEGFR-1, VEGFR-2, VEGFR-3 and two non protein kinase co-receptors (neutropilin -1 and ...neutropilin-2). ...
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Age-related macular degeneration: experimental and emerging treatments
... the VEGF production (by post-transcriptional gene silencing) but has no effect on the VEGF already produced and may explain why its effective- ness is often ...off VEGF production for prolonged ...
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Key words
... their VEGF−A level. In the first subgroup the plasma and serum VEGF−A concentrations were not significantly different from those of the healthy ...serum VEGF−A levels were significantly higher than ...
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VEGF INHIBITORS FOR CANCER THERAPY
... of VEGF is provided by cPLA, activation and biosynthesis of ...the VEGF signal to microfilaments inducing rearrangements of the Actin cytoskeleton that regulate endothelial cell migration by modulating the ...
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What is the impact of intravitreal injection of conbercept on neovascular glaucoma patients: a prospective, interventional case series study
... anti- VEGF agents, the concentration of VEGF-A in the aque- ous humour significantly decreased, but the neovascular- ization of the iris and chamber angle were incompletely ...increasing VEGF-A ...
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