VEGF-R
Microflow of fluorescently labelled red blood cells in tumours expressing single isoforms of VEGF and their response to VEGF-R tyrosine kinase inhibition
... The VEGF receptor family of proteins belong to the protein tyrosine kinases that regulate multiple cellular processes that contribute to tumour development and progression, including cell proliferation, ...
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Granulocyte-Colony Stimulating Factor Receptor, Tissue Factor, and VEGF-R Bound VEGF in Human Breast Cancer In Loco
... procoagulant, both under physiological condi- tions and in the state of neoplastic disease [13, 14]. Additionally, it was documented that TF activi- ty contributes to cancer progression and stimu- lation of new vessel ...
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Vascular endothelial growth factor regulates osteoblast survival – evidence for an autocrine feedback mechanism
... active VEGF receptors. Using a biotinylated VEGF binding assay we were able to show that ...istered VEGF to the culture ...of VEGF 165 and PlGF, at compara- ble concentrations, can therefore ...
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Vascular endothelial growth factor is an essential molecule for mouse kidney development: glomerulogenesis and nephrogenesis
... of VEGF receptors has not been reported in immature mesenchymal cells or ureteric bud epithelial cells (14, 15), direct effect of VEGF on those cells seems to be less ...endogenous VEGF activity, ...
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Age-related macular degeneration: experimental and emerging treatments
... Results: Experimental treatments to preserve vision in patients with exudative AMD include blocking vascular endothelial growth factor (VEGF), binding VEGF, and modulating the VEGF receptors. ...
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Src blockade stabilizes a Flk/cadherin complex, reducing edema and tissue injury following myocardial infarction
... where VEGF is overexpressed, we have shown that Src inhibition reduces tissue edema and ...permeability. VEGF adminis- tration alone is sufficient to provoke such damage, whether by a one- time injection or ...
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The association of angiogenic factors and chronic kidney disease
... suggested VEGF expression was reduced in the biop- sied kidney tissue from patients with diabetic nephropathy ...soluble VEGF receptor-1 (sVEGFR-1) and reduced VEGFR-2 were associated with mortality in ...
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1,2-Dioleoyl-3-Trimethylammonium-Propane (DOTAP)-Formulated, Immune-Stimulatory Vascular Endothelial Growth Factor A Small Interfering RNA (siRNA) Increases Antitumoral Efficacy in Murine Orthotopic Hepatocellular Carcinoma with Liver Fibrosis
... the VEGF/VEGF receptor pathway via siRNA to treat tumors of different origin, like retinoblastoma, prostate carcinoma, colon adenocarci- noma, colon cancer, and glioblastoma in vitro and in vivo ...of ...
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Myc regulates VEGF production in B cells by stimulating initiation of VEGF mRNA translation.
... affect VEGF mRNA levels indicates that VEGF production is not a result of Myc- induced stress or hypoxia in B ...increases VEGF production 10-fold by a translational mechanism demonstrates that ...
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Investigation of VEGF and PDGF signals in vascular formation by 3D culture models using mouse ES cells
... in VEGF+ than that of VEGF–. On day 2, VEGF+ in- creased the EBs with budding, and the number of those EBs was remarkably higher than those of ...4, VEGF– rapidly increased those EBs with ...
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VEGF - A Precis’
... induces VEGF expression and related molecules that initiate ...both VEGF and its receptors are shown to be highly expressed in metastatic carcinomas and the expression of these proteins directly correlates ...
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PREDICTIVE VALUE OF VASCULAR ENDOTHELIAL GROWTH FACTOR IN WOMEN UNDERGOING INTRACYTOPLASMIC SPERM INJECTION WITH HIGH RISK FOR OVARIAN HYPERSTIMULATION SYNDROME
... serum VEGF concentrations. This finding may be due to the fact that VEGF is not produced only by the ovary, but also is expressed in various ...serum VEGF concentration is affected by its release ...
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VEGF A165b protects against proteinuria in a mouse model with progressive depletion of all endogenous VEGF A splice isoforms from the kidney
... identified VEGF-A as one of the genes significantly correlated with renal function, both in glomerular and tubulointerstitial compartments (Martini et ...of VEGF-A in the kidney, which is affected in ...
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Anti-angiogenic efficacy of 5′-triphosphate siRNA combining VEGF silencing and RIG-I activation in NSCLCs
... Figure 2: ppp-VEGF inhibits tumor angiogenesis in vivo, inhibits tubule-like structure formation, and decreases migration of endothelial cells in vitro. A. LLC cells were subcutaneously implanted into C57BL/6 ...
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Obesity-associated insulin resistance is correlated to adipose tissue vascular endothelial growth factors and metalloproteinase levels
... MMPs are proteolytic enzymes that play an essential role in extracellular matrix remodeling and VEGF regula- tion. MMPs are involved in two important events of this process and control proteolysis and adipogenesis ...
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Role of VEGF-A in angiogenesis promoted by umbilical cord-derived mesenchymal stromal/stem cells: in vitro study
... The migration of EA.hy926 cells to UC-MSC-released chemoattractants was measured by transwell chamber migration assay. UC-MSCs were seeded in a 24-well plate (10 5 cells in 600 μl of growth media per well). One-half of ...
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Induction of erythropoiesis by hypoxia-inducible factor prolyl hydroxylase inhibitors without promotion of tumor initiation, progression, or metastasis in a VEGF-sensitive model of spontaneous breast cancer
... In summary, FG-4497 and roxadustat treatments that stimulated EPO and erythropoiesis were not observed to exacerbate tumor development or progression in the NeuYD model, via VEGF-dependent or other pathways. The ...
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Review Article Molecular mechanisms of lymphatic metastasis in solid tumors of the gastrointestinal tract
... Insulin like growth factor (IGF): The IGF system consists of the ligands insulin like growth factor 1 (IGF-1) and insulin like growth factor 2 (IGF-2) and their receptors IGF-1R, IGF-2R and 6 IGF binding proteins ...
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Association between VEGF–460T/C gene polymorphism and clinical outcomes of nasopharyngeal carcinoma treated with intensity-modulated radiation therapy
... the VEGF –460C-allele carrier (T/C + CC) was regarded as an inferior prognostic factor of survival according to ...the VEGF –460C-allele carriers in NPC, and the role of NACT remains ...
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Apparent Diffusion Coefficient Histogram Analysis Stratifies Progression Free Survival in Newly Diagnosed Bevacizumab Treated Glioblastoma
... sitivity for nonenhancing tumor progression, 2 reviewers (W.B.P. and A.L.) retrospectively assessed the MR imaging and backdated the time of progression to the earliest convincing worsening of FLAIR signal-intensity ...
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