White matter pathology
Diffusion Tensor Imaging Mapping of Brain White Matter Pathology in Mitochondrial Optic Neuropathies
... WM pathology involving multiple brain systems, a finding in close agreement with the mounting clinical evidence that subjects carrying OPA1 mutations may have a mul- tisystem neurologic disease (DOA “plus”), ...
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Gender differences in white matter pathology and mitochondrial dysfunction in Alzheimer’s disease with cerebrovascular disease
... first time, we report sex-specific molecular differences in white matter pathology and mitochondrial proteomes in the temporal lobe of AD + CVD patients. In particular, we observed that ...
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White matter pathology in Parkinson's disease: The effect of imaging protocol differences and relevance to executive function
... investigate white matter structure in neurological and neuropsychiatric ...of white matter in patients and age-matched controls, comparing two datasets acquired with dif- ferent imaging ...
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Neuroinflammation and white matter pathology in schizophrenia: systematic review
... in white rather than gray matter ...abnormal white as well as gray matter volumes in schizophrenia but not ...orbitofrontal white matter neuronal density was increased in ...
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Loss of USP18 in microglia induces white matter pathology
... the white matter ...the white matter that strongly resembled the neuropatho- logical state in several human ...the white matter induce white matter abnor- malities ...
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Cortical and Leptomeningeal Cerebrovascular Amyloid and White Matter Pathology in Alzheimer’s Disease
... In conclusion, the results of this study strongly support our hypothesis that compromised drainage of interstitial fluid from the WM in AD is due to blockage of the cortical and leptomenin- geal perivascular spaces by ...
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Quality of General Movements Is Related to White Matter Pathology in Very Preterm Infants
... ipsilateral involvement of a cerebral hemisphere, basal ganglia, and internal capsule on the MRI scan. Cioni et al 6 investigated the relationship among early neurologic examination, GMs, and outcome at 2 years in a ...
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The effects of environmental enrichment on white matter pathology in a mouse model of chronic cerebral hypoperfusion
... WM pathology is indicative of overall subcortical damage and neuronal disconnectivity between cerebral cortices that result in cognitive and motor deficits observed in ...
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Diffusion tensor imaging and tractwise fractional anisotropy statistics: quantitative analysis in white matter pathology
... The prerequisite of statistical analysis at group level and arithmetic averaging of subject data is the normalisation to a standardised stereotactic space, e.g. the Montreal Neu- rological Institute (MNI) space. MNI ...
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White matter pathology and disconnection in the frontal lobe in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL)
... Results: The degree of WM pathology consistently scored higher across all brain regions in CADASIL subjects (P < 0.01) with the WM underlying the primary motor cortex exhibiting the most severe change. SMI32 ...
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White Matter Tract Pathology in Pediatric Anoxic Brain Injury from Drowning
... This study has limitations. Diffusion-weighted MR imaging is known to be extremely sensitive to subject motion, eddy currents, and magnetic field inhomogeneities. 18 Additionally, we were rather stringent with data ...
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White matter hyperintensities and normal-appearing white matter integrity in the aging brain
... increases in MD and T1, and the decreases in FA and MTR seen in established WMH. However, the increase in MD in NAWM even with the mildest Fazekas score suggests that altered water mobility in the interstitial space may ...
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Spatial Correlation of Pathology and Perfusion Changes within the Cortex and White Matter in Multiple Sclerosis
... and pathology in anatomically connected WM tracts in patients with RRMS, SPMS, and primary-progres- sive MS, demonstrating a relationship between NAWM tract frac- tional anisotropy and deep GM and ...
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Parietal white matter lesions in Alzheimer’s disease are associated with cortical neurodegenerative pathology, but not with small vessel disease
... © The Author(s) 2017. This article is an open access publication a measure of hypoperfusion. WML severity was associ- ated with both axonal loss and demyelination in AD, but only with demyelination in controls. Calpain ...
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On Describing Human White Matter Anatomy: The White Matter Query Language
... major white matter tracts in the human brain based on a neuroanatomist’s ex- pert ...describe white matter tracts and to automatically extract them from diffusion MRI ...describing ...
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Evaluation of Four Supervised Learning Schemes in White Matter Hyperintensities Segmentation in Absence or Mild Presence of Vascular Pathology
... results of the WMH segmentations from the same individual at different time points. For more details and to access these segmentations, please refer to http: //hdl.handle.net/10283/2186. The preprocessing steps of the ...
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Subcortical Deep Gray Matter Pathology in Patients with Multiple Sclerosis Is Associated with White Matter Lesion Burden and Atrophy but Not with Cortical Atrophy: A Diffusion Tensor MRI Study
... gray matter volume ...of white matter connections could lead to trans-synaptic axonal degeneration and retrograde degeneration of neurons with alteration of the microstructural architecture of SDGM ...
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Age Differentiation within Gray Matter, White Matter, and between Memory and White Matter in an Adult Life Span Cohort.
... and white-matter organisation (fractional anisotropy from Diffusion-weighted MRI), we found evidence for differentiation of grey and white matter, such that the covariance between brain ...
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The Contributions of MRI Based Measures of Gray Matter, White Matter Hyperintensity, and White Matter Integrity to Late Life Cognition
... AD pathology, which results in specific injury to pyramidal cell neurons in cortical layers III and IV respon- sible for cortical-cortical ...that white matter in- tegrity has no direct bearing on ...
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Meningeal and cortical grey matter pathology in multiple sclerosis
... the white matter of the central nervous system, recent pathological and imaging studies have established that cortical demyelination is common in multiple sclerosis and more extensive than previously ...
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