Wnt signalling
Wnt signalling in lung development and diseases
... of Wnt expression in embryonic and adult mouse lung suggests that Wnt pathways are important for cell fate decisions and differentiation of lung cell ...canonical Wnt signalling in lung ...
10
RPE specification in the chick is mediated by surface ectoderm derived BMP and Wnt signalling
... different signalling pathways integrate to regulate cell fate decisions within the ...that Wnt-mediated GSK3β inhibition elicits RPE development in ...with Wnt signalling prevents MITF ...
11
Characterization of the Wnt signalling system in the coral Acropora millepora
... The Wnt signalling system plays essential roles in many animal developmental ...metazoans Wnt signalling is proposed to be primarily responsible for axis formation and patterning along the ...
161
Connective tissue growth factor modulates WNT signalling and interacts with the WNT receptor complex
... Willebrand factor type C repeat (VWC), and also displays similarities with the cysteine repeats in the BMP antagonist Short gastrulation (Sog)/Chordin (Abreu et al., 2002; Sasai et al., 1994). Domain 3 has homology with ...
11
Wnt Signalling During F9 Cell Differentiation
... of WNT signalling, such as Dab2. DAB2 inhibits WNT/β-catenin signalling by binding LRP6 and promoting its internalization, as well as by interacting with and stabilizing AXIN, preventing ...
86
A secreted splice variant of the Xenopus frizzled-4 receptor is a biphasic modulator of Wnt signalling
... Wnt5a-type ligands such as Wnt5a and Wnt11 regulate β-catenin-independent signalling. In Xenopus embryos they orchestrate morphogenetic cell movements by regu- lating planar cell polarity (PCP) in the mesoderm and ...
6
Wnt signalling during limb development
... facilitating Wnt function – one possible mechanism may be to increase the solubility of the Wnt molecule to aid its diffusion (Lin et ...of Wnt ligand for the ...block Wnt activity suggesting ...
10
WNT signalling pathway in oral lesions
... addition, WNT/-catenin signalling plays a fundamental role in bone biology, and aberrations in WNT pathway play a critical role in bone destruction related to periapical and periodontal ...regulate ...
6
Wnt signalling: conquering complexity
... of Wnt signalling, are a recurrent theme in many types of human tumours ...-independent Wnt signalling are now considered to be promising therapeutic targets (Daulat and Borg, 2017; Zhang and ...
9
An analysis of wnt signalling molecules in Xenopus pronephros development
... the wnt signalling molecules are involved during developmental pocesses, including the kidney ...the signalling events controlling pronephros formation, two direct screens of known wnt and ...
292
Quantitative Expression and Co-Localization of Wnt Signalling Related Proteins in Feline Squamous Cell Carcinoma
... key signalling pathways in FOSCC, such as the Wnt pathway is, we believe, an important first ...of Wnt/ß-catenin transcription are up-regulated in FOSCC as they are in human squamous cell carcinomas ...
17
Ovarian hormones through Wnt signalling regulate the growth of human and mouse ovarian cancer initiating lesions
... activated Wnt signalling to be a marker for precursor lesions of OC and successfully develops a mouse model that mimics the earliest events in pathogenesis of OC by constitutively activating ...
18
Wnt signalling is a bi-directional vulnerability of cancer cells
... for Wnt signalling activation, our findings suggest that MYCN-β-catenin protein interaction reverses the normal transcriptional regulation of β-catenin target ...nor Wnt Agonist 1 treatment strongly ...
22
GATA transcription factors integrate Wnt signalling during heart development
... non-canonical Wnt signalling. We have confirmed that Wnt/ β -catenin signalling inhibits cardiogenesis (Cohen et ...overrule Wnt/ β - catenin-mediated inhibition of cardiogenesis, that ...
6
Wnt signalling modulates transcribed-ultraconserved regions in hepatobiliary cancers.
... differentiate Wnt/ β -catenin dependent HCC from normal liver and from β -catenin negative diethylnitrosamine (DEN)-induced ...with Wnt/ β -catenin ...the Wnt pathway in liver cancers and drives ...
10
Regulation of neuritogenesis in neuroblastoma cells by components of the Wnt signalling pathway
... a Wnt ligand to a Frizzled receptor and an LRP co-receptor results in dissociation of the Axin/GSK-3/p-catenin complex, but the mechanism by which this occurs is not ...
190
Secreted HMGB1 from Wnt activated intestinal cells is required to maintain a crypt progenitor phenotype
... induction was undertaken (Figure 2B). This demonstrated the acquisition of hyper-acetylated and methylated forms of HMGB1 following Apc loss, both of which are forms that are associated with release due to inflammasome ...
9
Tankyrase Requires SAM Domain-Dependent Polymerization to Support Wnt-β-Catenin Signaling.
... with protruding ARCs and PARP domains (Knight et al., 2011). Secondly, Tankyrase polymerisation and its ability to activate β -catenin dependent transcription correlate, and mutagenesis suggests that activation may ...
67
Progressive restriction of otic fate: the role of FGF and Wnt in resolving inner ear potential
... of signalling factors (Baker and Bronner-Fraser, ...the Wnt signalling protein Wnt8c (Ladher et al., 2000). FGF and Wnt signalling are then thought to induce otic fate in adjacent, ...
10
The ciliary Frizzled-like receptor Tmem67 regulates canonical Wnt/β-catenin signalling in the developing cerebellum via Hoxb5
... canonical Wnt/β-catenin signalling, proliferation and ...canonical Wnt signalling, following loss of TMEM67, was dependent on ...canonical Wnt signalling in Tmem67 −/− mutant ...
15