zonula occludens
Arecoline induces TNF-alpha production and Zonula Occludens-1 redistribution in mouse Sertoli TM4 cells
... formation. Zonula occludens (ZO-1), a member of the membrane-associated guanylate kinase (MAGUK) homologue protein family, is a tight junction protein ...
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Sequence-based Analysis of Zonula Occludens Toxins Identified by Comparative Genomics in Non-Toxigenic Vibrio Parahaemolyticus Strains Isolated in Southern Chile
... The Zot protein homology was determined using HHpred [33]. Amino acids aligned with a probability of 99.72% in the N-terminal region of the "Zonula Occludens Toxin" from N. meningitidis MC58 ...
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Effects of Interleukin 13 and Montelukast on the Expression of Zonula Occludens 1 in Human Podocytes
... in zonula occludens-1 (ZO-1) are induced by interleukin-13 (IL-13) in the experi- mental minimal-change nephrotic syndrome (MCNS) model and to determine whether montelukast, a leukotriene receptor ...
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Glomerular changes and alterations of zonula occludens 1 in the kidneys of Plasmodium falciparum malaria patients
... PRBCs. This leads to the disruption of the EC barrier and eventually affects vascular permeability. Tight junctions are located apical to the EC surface and composed of multiple transmembrane, scaffolding, and signaling ...
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Modulation of intestinal tight junctions by Zonula occludens toxin permits enteral administration of insulin and other macromolecules in an animal model
... that Zonula occludens toxin (Zot), a protein elaborated by Vibrio cholerae (7, 8), induced modifications of cytoskeletal organization that lead to the opening of tj related to the PKC a -dependent ...
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Zonula occludens toxin modulates tight junctions through protein kinase C dependent actin reorganization, in vitro
... The intracellular signaling involved in the mechanism of action of zonula occludens toxin (ZOT) was studied using several in vitro and ex vivo models. ZOT showed a selective effect among various cell lines ...
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Zonula occludens toxins and their prophages in Campylobacter species
... The zot -containing prophages in Campylobacter species were identified and compared with known prophage proteins and other viral proteins using protein sequence alignment and protei[r] ...
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Examination of the effects of Campylobacter concisus zonula occludens toxin on intestinal epithelial cells and macrophages
... Results: Campylobacter concisus Zot caused prolonged intestinal epithelial barrier damage, induced intestinal epithe- lial cell apoptosis, induced epithelial production of TNF-α and IL-8[r] ...
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Herb-partitioned moxibustion upregulated the expression of colonic epithelial tight junction-related proteins in Crohn’s disease model rats
... ZO-1: zonula occludens proteins-1; UC: ulcerative colitis; ECCO: European Crohn’s and Colitis Organization; SD: Sprague–Dawley; TNBS: trinitrobenzene sulfonic acid; NC: normal control; MC: model control; ...
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Kv1.3 channel blocker (ImKTx88) maintains blood–brain barrier in experimental autoimmune encephalomyelitis
... Blood–brain barrier is a brain-specific capillary bar- rier that is primarily formed by microvascular endothe- lial cells, which are surrounded by basement membranes, pericytes and astrocytes [6]. Tight junctions in ...
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<p>The Protective Effects of Juglanin in Cerebral Ischemia Reduce Blood–Brain Barrier Permeability via Inhibition of VEGF/VEGFR2 Signaling</p>
... stroke cases. 4 In ischemic conditions, tissues are starved of vital oxygen and nutrients due to reduced or obstructed blood flow, which leads to neural cell apoptosis, oxidative stress, and a robust inflammatory ...
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Original Article Increased ZO-1 expression predicts valuable prognosis in non-small cell lung cancer
... The integrity of intercellular contacts is crucial to epithelial homeostasis. During carcinogene- sis, epithelial cells lose their characteristic epi- thelial features and become increasingly motile and invasive [35]. ...
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The DLGAP family: neuronal expression, function and role in brain disorders
... MAGUKs: Membrane-associated guanylate kinases; mGluRs: Metabotropic glutamate receptors; NMDA: N-methyl-D-aspartate; OCD: Obsessive compulsive disorder; PDZ: Zonula occludens-1 protein; [r] ...
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DISTRIBUTION OF THE USP GENE IN UROPATHOGENIC ESCHERICHIA COLI FROM PATIENTS WITH URINARY TRACT INFECTION AND INVESTIGATION OF ANTIBIOTIC RESISTANCEAlieh Lotfi Nejad, Mansour Amin, Shekoofeh Sadat Etemadzadeh, Mohammad Hossein RezaeianDOWNLOAD/VIEW
... Urinary tract infection (UTI) is one of the most frequent infectious diseases around the world that caused by uropathogenic Escherichia coli (UPEC). Uropathogenic-specific protein (usp) is homologous to the Vibrio ...
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German Cockroach Extract Induces Matrix Metalloproteinase 1 Expression, Leading to Tight Junction Disruption in Human Airway Epithelial Cells
... Fig. 5. ERK/MAPK pathway modulates MMP1 transcriptional regulation and tight junction disruption. (A) Phosphorylated and total ERK1/2 was detected in H292 cells pretreated with PD98059 for 1 h and treated with GCE for 24 ...
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Principles and roles of mRNA localization in animal development
... Establishment and maintenance of epithelial cell polarity rely on the asymmetric distribution of evolutionarily conserved protein complexes, such as the Crumbs complex. This complex is composed of the transmembrane ...
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Effects of Kaixinjieyu, a Chinese herbal medicine preparation, on neurovascular unit dysfunction in rats with vascular depression
... The BBB is a tightly sealed barrier between the circu- lating blood and the central nervous system, consisting of brain microvascular endothelial cells which are char- acterized by the presence of tight junctions (TJs) ...
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Expression and localization of claudins-3 and -12 in transformed human brain endothelium
... BBB: Blood brain barrier; hCMEC/D3: Human cerebral microvascular endothelial cell D3; TJ: Tight junction; ZO-1, 2: Zona occludens-1, 2; JAM-1: Junctional adhesion molecule-1; VE-Cadherin[r] ...
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