[PDF] Top 20 A cyclophilin-dependent mitochondrial pore
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A cyclophilin-dependent mitochondrial pore
... A mitochondrial lesion in the form o f a Ca^^ sensitive non-selective inner membrane pore is reputed to contribute to the progression of this form of injury and the pore is blocked by CsA This study ... See full document
238
Stress induced dynamic regulation of mitochondrial STAT3 and its association with cyclophilin D reduces mitochondrial ROS production
... Currently, the fate of mitoSTAT3 following stimulation is unknown. Proteolysis of mitoSTAT3 is consistent with the kinetics of its loss from the mitochondria. We detected proteolytic fragments of STAT3 in the ... See full document
56
Mitochondrial β amyloid in Alzheimer's disease
... the mitochondrial matrix and translocates to the inner mitochondrial membrane during times of oxidative stress where it is thought to play a role in the opening of the mitochondrial permeability ... See full document
11
The influence of ATP-dependent K(+)-channel diazoxide opener on the opening of mitochondrial permeability transition pore in rat liver mitochondria
... Возврат Са 2+ в матрикс после перевода поры в закрытое со- стояние с помощью циклоспорина А также по- казывает, что при открывании поры происхо- дит активация циклического транспорта С[r] ... See full document
11
Activation of sirtuin 1/3 improves vascular hyporeactivity in severe hemorrhagic shock by alleviation of mitochondrial damage
... shock. Mitochondrial permeability transition (mPT) pore opening in arteriolar smooth muscle cells (ASMCs) is involved in the pathogenesis of vascular ...underlying mitochondrial injury in ASMCs ... See full document
14
Mitochondria in energy limited states: mechanisms that blunt the signaling of cell death
... and cyclophilin D, yet the traditional assay used to measure opening of the MPTP (mitochondrial swelling) clearly showed that the pore did not respond to the addition of calcium and phosphate in ... See full document
12
Human Coronavirus-Induced Neuronal Programmed Cell Death Is Cyclophilin D Dependent and Potentially Caspase Dispensable
... is cyclophilin D (CypD), which is a member of the cyclophilin family possessing peptidyl-prolyl cis- trans isomerase activity (29, ...inner mitochondrial membrane and is known to be responsible for ... See full document
13
ACTIVITY OF APIGENIN AND QUERCETIN ON RAT HEPATIC MITOCHONDRIAL PERMEABILITY TRANSITION PORE
... of mitochondrial functions such as permeability transition has been found to play a vital role in the apoptotic process induced by certain anti-cancer ...on mitochondrial membrane permeability transition ... See full document
12
The effect of ATP-dependent K(+)-channel opener on transmembrane potassium exchange and reactive oxygen species production upon the opening of mitochondrial pore
... повышается также скорость входа протонов в матрикс (рис.. Влияние МрТр на трансмембранный обмен ионов в митохондриях. Открывание МРТР, как уже было показано нами [11], приводит к[r] ... See full document
15
Mitochondrial permeability transition pore induces mitochondria injury in Huntington disease
... to mitochondrial cyclophilin D and blocks the calcium-induced mPTP opening ...the mitochondrial inner membrane (MIM) to become permeable and leads to the loss of the ions con- centration gradients ... See full document
19
SUN1 Regulates HIV-1 Nuclear Import in a Manner Dependent on the Interaction between the Viral Capsid and Cellular Cyclophilin A
... function of SUN1 could be compensated. To investigate whether endogenous SUN1 is involved in the process of HIV-1 nuclear entry, we used siRNAs to downregulate SUN1 expression and analyzed the levels of the late RT ... See full document
15
Anoxia mediated calcium release through the mitochondrial permeability transition pore silences NMDA receptor currents in turtle neurons
... protein cyclophilin A, which, when bound to CsA, produces a complex that inhibits the calcium-/calmodulin-dependent phosphatase 2B, also known as calcineurin (Walsh et ... See full document
13
Cyclophilin D controls mitochondrial pore–dependent Ca2+ exchange, metabolic flexibility, and propensity for heart failure in mice
... Cyclophilin D (which is encoded by the Ppif gene) is a mitochondrial matrix peptidyl-prolyl isomerase known to modulate opening of the mitochondrial permeability transition pore (MPTP). Apart ... See full document
9
HIV 1 capsid undergoes coupled binding and isomerization by the nuclear pore protein NUP358
... The cyclophilin domain of NUP358 has been shown to be an active isomerase, although it possesses much weaker catalytic activity than CypA when tested using a synthetic proline-containing peptide substrate ...time ... See full document
12
Cyclophilin B facilitates the replication of Orf virus
... Fig. 2 Verification of the protein expression levels of CypB gene identified from the forward SSH library with western blotting. The MDBK cells at hours 0, 2, 4, 8, 12, 18 and 24 post infection were collected and lysed ... See full document
11
Defective TNF α–mediated hepatocellular apoptosis and liver damage in acidic sphingomyelinase knockout mice
... Previous studies have shown that various strategies — for example, cycloheximide, galactosamine, or acet- aminophen — rendered hepatocytes sensitive to TNF-α exposure which induced apoptotic and necrot- ic cell death ... See full document
13
Putative Pore-lining Residues and Intracellular Magnesium Influence Connexin50 Unitary Gap Junction Channel Conductance
... conductance dependent manner (Veenstra et al. 1992). Pore-lining domains are most likely implicated in regulating channel conductance by altering pore diameter, using electrostatic forces to ... See full document
145
Comparison of Protein Profiles in Sputum between COPD and Acute Exacerbation of COPD
... of cyclophilin B in sputa from patients with COPD and COPD with acute exacerbation ...with cyclophilin B. Cyclophilin B concentrations were lower in sputum from subjects with COPD (n = 4) versus ... See full document
6
Effect of Methanol Leaf Extract of Blighia Sapida on Mitochondrial Membrane Permeability Transition Pore Opening and Blood Glucose Levels in Normal and Streptozotocin-Induced Diabetic Rats
... inhibit mitochondrial-mediated apoptosis and thus mitigate the excessive tissue wastage that is a hallmark of ...on mitochondrial permeability transition (MPT) pore opening in normal and ... See full document
11
EVIDENCE FOR HYDRATION DEPENDENT CLOSING OF PORE STRUCTURES IN THE CUTICLE OF PERIPLANETA AMERICANA
... to be the only explanation. Indeed, the correlation of the magnitude of the change with hydrated conductance (the larger the number of open pores in a given area, the larger the possible change on closing), further ... See full document
12
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