[PDF] Top 20 α-Synuclein and neuronal cell death
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α-Synuclein and neuronal cell death
... of α-synuclein that have been reported and some of these are found more often in pathological circumstances than under normal conditions, such as nitration or ...of α-synuclein is associated ... See full document
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Suppression of MAPK attenuates neuronal cell death induced by activated glia-conditioned medium in alpha-synuclein overexpressing SH-SY5Y cells
... minergic neuronal (DN) loss in the substantia nigra and the presence of intracellular inclusions called Lewy bodies, largely composed of aggregated α-synuclein (α- syn) [4, ...of α-syn ... See full document
8
Nigrostriatal neuronal death following chronic dichlorvos exposure: crosstalk between mitochondrial impairments, α synuclein aggregation, oxidative damage and behavioral changes
... Evidence for the involvement of oxidative stress in PD has also been obtained from PD patients. Increased lipid peroxidation and oxidative damage to DNA and proteins have been observed in SN of PD patients [19]. We also ... See full document
20
Interleukin-1 mediates Alzheimer and Lewy body pathologies
... vitro cell culture experiments and an in vivo pellet-implantation ...elevate neuronal synthesis of βAPP and release of sAPP and increase levels of α-synuclein and phosphor- ylated-tau; ... See full document
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Glucocerebrosidase activity, cathepsin D and monomeric α-synuclein interactions in a stem cell derived neuronal model of a PD associated GBA1 mutation.
... of α -synuclein and generation of its carboxy-terminally truncated species in lysosomes (Sevlever et ...affects α-synuclein processing, aggregation and toxicity; its defi- ciency leads to ... See full document
8
LRRK2 activity does not dramatically alter α-synuclein pathology in primary neurons
... in α -synuclein pathology at 21 DPT However, it has recently been demonstrated that G2019S neurons may show time-dependent changes in α-synuclein pathology that don’t become apparent until 18 ... See full document
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Organotypic slice culture model demonstrates inter-neuronal spreading of alpha-synuclein aggregates
... contiguous α-syn expression, we gener- ated hippocampal slices from α-syn KO pups in which neuronal α-syn expression was established locally using an AAV vector expressing ...AAV-mediated ... See full document
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... dopaminergic cell models with FeCl₂ was evaluated with respect to cell toxicity and α- synuclein gene expression which is one of the causative agent in the onset of Parkinson’s ...induced ... See full document
10
Structural Remodeling Of Alpha-Synuclein By Small Molecules: A Novel Path To Neuroprotective Therapeutics
... protein α (CSPα) is a chaperone that is essential for synaptic health; its deletion in mice leads to a decrease in SNARE protein complexes, nerve terminal degeneration, motor impairment and ...mice, ... See full document
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Levels of cerebrospinal fluid α-synuclein oligomers are increased in Parkinson’s disease with dementia and dementia with Lewy bodies compared to Alzheimer’s disease
... of α-synuclein overexpression in the pathogenesis of these ...of α-synuclein protein were identified as the main components of LBs, the pathologic hallmark of PD, PDD, and DLB ...Therefore, ... See full document
6
Induction of CNS α-synuclein pathology by fibrillar and non-amyloidogenic recombinant α-synuclein
... αS neuronal inclu- sion formation ...with cell culture studies that showed that both soluble and aggre- gated αS are potent activators of inflammation ... See full document
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Animal modeling an oligodendrogliopathy – multiple system atrophy
... of α-synuclein into their cytosol [100–102], apparently via dynamin- depednent endocytosis [101, ...recombinant α-synuclein taken up by the cells formed aggregates of varying size, including ... See full document
15
Beclin1 and HMGB1 ameliorate the α-synuclein-mediated autophagy inhibition in PC12 cells
... including cell development, differ- entiation, inflammation, metabolism and death ...by α-synuclein overex- pression [31], implying a direct role in modulating au- tophagic degradation of ... See full document
10
Evaluation of Mitochondrial Dysfunction and α-Synuclein Aggregation in Yeast Models of Parkinson’s Disease
... progressive death of dopaminergic neurons in the human ...of α - synuclein, as well as the presence of reactive oxygen species (ROS), are thought to contribute to this ...of α ... See full document
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Genetic Evidence in Yeast Model Implicates Autophagy in the Degradation of Parkinson's Disease Protein alpha-Synuclein
... dopaminergic neuronal death in the substantia nigra, likely due to the misfolding and aggregation of the protein ...of α-synuclein reduces toxicity and ...from α-synuclein ... See full document
10
Extracellular α-synuclein levels are regulated by neuronal activity
... the neuronal activity, these inhibitors were added both in treatment period and pre-incubation period (for 2 h at 37 ...remove cell debris and the supernatant was used for the further ...(Roche). ... See full document
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Neuron-to-neuron α-synuclein propagation in vivo is independent of neuronal injury
... h α -syn-carrying AAV ...h α -syn-AAV prep 1 (n = 7) or h α -syn-AAV prep 2 (n = 7) into the vagus ...h α -syn-AAV prep 1 or (c) prep ...anti-h α -syn ...in cell size after ... See full document
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rAAV2/7 vector-mediated overexpression of alpha-synuclein in mouse substantia nigra induces protein aggregation and progressive dose-dependent neurodegeneration
... of α-synuclein at the different viral vector doses, we performed immunohisto- chemical stainings for TH in the ...of α-synuclein vector (Figure ...dopaminergic cell loss was observed at ... See full document
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Conformational templating of α-synuclein aggregates in neuronal-glial cultures
... All procedures were performed according to the NIH Guide for the Care and Use of Experimental Animals and were approved by the University of Florida Institu- tional Animal Care and Use Committee. Astrocyte cul- tures ... See full document
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Role of cytochrome c in α-synuclein radical formation: implications of α-synuclein in neuronal death in Maneb- and paraquat-induced model of Parkinson’s disease
... with α-synuclein and tyrosine hydroxylase, which is a marker enzyme for dopaminergic neurons ...on α- synuclein. To test for α-synuclein radical formation, α- ... See full document
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