[PDF] Top 20 Accumulation of Deleterious Mutations During Bacterial Range Expansions

... of bacterial fitness than under radial ex- pansion with mixed ...many mutations (128 and 142 ...nonsynonymous mutations in the mlc (makes large colony) gene, known to enable pro- longed growth on ... See full document

... of deleterious mutations on paternal and maternal genomes are identical, but it appears that under specific conditions recombination may still lead to a lower vari- ance of their ... See full document

... sented the first generation of the asexual MA lines. We refer selfing lines, all derived from a common ancestral strain to a generation as a full cycle of spore germination, mycelial of A. nidulans. In these lines, ... See full document

... the accumulation of deleterious mutations by the onset of Muller’s ...the accumulation of deleterious mutations in the potyvirus Tobacco etch virus ...between deleterious ... See full document

... spontaneous mutations in the 1977 and Garcı´a-Dorado et ...from mutations of outbred and inbred populations for the fitness trait, induced by EMS and by transposable-element inser- and estimates are ... See full document

... of bacterial lineages that are buff- ered from environmental changes are the ancient endosymbiotic associations of bacteria living within specialized polyploid host cells (mycetocytes), for example the 100–250 ... See full document

... nonlethal deleterious mutations was twice Measuring rates and effects of viability mutations in that to lethals, for which an estimate was available at Drosophila: The idea of a mutation ... See full document

... which deleterious mutations accumulate, and that such an effect may be strong enough to drive these alleles to fixation, I performed computer simulations that would mimic the process of mutation ... See full document

... Crow, J., and M. Kimura, 1970 An Introduction to Population Genetics Lynch, M., J. Conery and R. Burger, 1995b Mutation accumulation Theory. Harper & Row, New York. and the extinction of small populations. Am. ... See full document

... weakly deleterious mutations, this “background selection” can reduce the effective population size by orders of magnitude (24, ...a range of r/m values from ... See full document

... ATP-dependent bacterial chaperonin that assists in protein folding, is among the most abundant proteins in independently derived endo- ...slightly deleterious fix- ations that destabilize proteins (Moran ... See full document

... two mutations were not acquired as readily as the deterministic model would have ...of mutations are required, the expected number of times that the adapted mutant occurs will be small, if not 0, when ... See full document

... results were seen when the latter codons were included occurrence of relatively rare nonsynonymous polymor- (data not shown). Although there were significant dif- phisms but not of synonymous polymorphisms. The ferences ... See full document

... mtDNA mutations in neuro- degenerative disorders have been inconsistent is that they may be acquired in the course of the disease as a consequence of a prior specific ...these mutations would accumulate in ... See full document

... The skeptical reader should treat our model as a ‘black box’, which is verified by comparing its predictions to empirical observations. The predicted thermodynamic stability of natural proteomes is posi- tively ... See full document

... female deleterious mutation rate is lower than the male mutation rate may be unrealistic if the number of insertions and deletions is ...of mutations, because it is extremely hard to infer the exact nature ... See full document

... slightly deleterious alleles, the ruby- the evolution of X dosage compensation and of Y-inac- in-the-rubbish process is two orders of magnitude faster tivation on a chromosome “block by block” basis; the than ... See full document

... the deleterious mutants play crucial roles (W ang et ...of deleterious mutations is large enough that selection is more important than drift, inbreeding load will be rapidly purged (G le ´ min 2003); ... See full document

... ATM mutations (one is likely to be deleterious) in the family promoted us to investigate the frequency of deleterious ATM germline mutations in gastric cancer ...nonsense mutations in ... See full document

... Figure 5 Ensemble survival probability predictions compared to fi xation probabilities in whole-population simulations. Solid curves plot the bounds delineated by Equation 9. Points each plot the fraction of 5000 ... See full document