[PDF] Top 20 Alpha/Beta Interferon and Gamma Interferon Synergize To Inhibit the Replication of Herpes Simplex Virus Type 1
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Alpha/Beta Interferon and Gamma Interferon Synergize To Inhibit the Replication of Herpes Simplex Virus Type 1
... At 1, 12, 24, and 36 h postinfection, Vero cells were treated with trypsin, resuspended in phosphate-buffered saline con- taining 10% fetal bovine serum, and then analyzed by using a FACSCalibur and CellQuest Pro ... See full document
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Differential Effect of Murine Alpha/Beta Interferon Transgenes on Antagonization of Herpes Simplex Virus Type 1 Replication
... Two prominent antiviral pathways activated following IFN- ␣/ receptor ligation are OAS and PKR (20). OAS leads to the activation of endo-RNase L, which degrades viral transcripts (53) and inactivates translational ... See full document
10
Human Parainfluenza Virus Type 3 Inhibits Gamma Interferon-Induced Major Histocompatibility Complex Class II Expression Directly and by Inducing Alpha/Beta Interferon
... HPIV3 replication in HT1080 cells with and without simulta- neous IFN-␥ treatment, we determined the production of in- fectious virus particles by plaque ...Table 1, IFN-␥-treated cells and untreated ... See full document
8
Alpha and Gamma Interferons Inhibit Herpes Simplex Virus Type 1 Infection and Spread in Epidermal Cells after Axonal Transmission
... strongly inhibit viral replication during the initial transmission and subsequent ...cell-free virus or via axon termini in a previously well-charac- terized neuron-EC two-chamber ... See full document
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Alpha/Beta Interferon Promotes Transcription and Inhibits Replication of Borna Disease Virus in Persistently Infected Cells
... ␣ 1 transgenic mice. To test whether IFN can inhibit the multiplication of BDV in the CNS, we infected newborn transgenic and nontransgenic lit- termates by the intracerebral route with a mouse-adapted BDV ... See full document
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Resistance to Alpha/Beta Interferon Is a Determinant of West Nile Virus Replication Fitness and Virulence
... to inhibit JAK-STAT signaling, we sought to determine the relative fitness levels of MAD78 and TX02 and whether or not WNV growth is enhanced in the absence of functional IFN- ␣ /  ...(lanes 1 to 3) or ... See full document
11
Gamma interferon expression during acute and latent nervous system infection by herpes simplex virus type 1.
... recently, replication-associated transcripts for ICP4 and thymidine kinase have been detected in latently infected ganglia by quantitative RNA PCR in the absence of detectable reactivation ...and virus ... See full document
10
The Antiviral Efficacy of the Murine Alpha-1 Interferon Transgene against Ocular Herpes Simplex Virus Type 1 Requires the Presence of CD4+, α/β T-Cell Receptor-Positive T Lymphocytes with the Capacity To Produce Gamma Interferon
... the virus, ultimately preventing the death of the host, an experiment was performed in which wild-type or ␣/␥␦ TCR dKO mice re- ceived plasmid vector or plasmid containing the IFN-␣1 in the cornea ... See full document
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Human gamma interferon and tumor necrosis factor exert a synergistic blockade on the replication of herpes simplex virus.
... 1354 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest The replication of herpes simplex virus type 1 HSV-1 is not inhibited in either HeLa or HEp-2 cells treated with hu[r] ... See full document
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Mice Lacking Alpha/Beta and Gamma Interferon Receptors Are Susceptible to Junin Virus Infection
... FIG. 2. JUNV virus replication in adult mice or in cell lines of murine origin. (A) Disseminated infection in JUNV-infected IFN- ␣ / ␥ R ⫺/⫺ mice. The levels of infectious JUNV in the brains and peripheral ... See full document
5
Herpes Simplex Virus 1 UL36USP Antagonizes Type I Interferon-Mediated Antiviral Innate Immunity
... viral replication was not influenced in UL36USP knockdown ...to inhibit IFN-  -triggered signaling and that the DUB activity was dispensable for its inhibitory ... See full document
12
Gamma Interferon Can Block Herpes Simplex Virus Type 1 Reactivation from Latency, Even in the Presence of Late Gene Expression
... including gamma interferon (IFN- ␥ ), tu- mor necrosis factor alpha, and interleukin-6, appear to be continuously present in latently infected mouse TG (5, 11, ... See full document
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RNA-Dependent Protein Kinase Is Required for Alpha-1 Interferon Transgene-Induced Resistance to Genital Herpes Simplex Virus Type 2
... HSV-2 replication in vitro (3), suggesting that IFN-inducible pathways can partially block HSV-2-mediated ...␣ 1 transgene into the vaginal lumen increased resistance to HSV-2 infection ... See full document
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Herpes Simplex Virus 1 Serine/Threonine Kinase US3 Hyperphosphorylates IRF3 and Inhibits Beta Interferon Production
... mutant virus induced a larger amount of IFN-  than WT ...the replication kinetics of the HSV-1 mutants and WT HSV-1 in both Vero cells ...viral replication compared with WT ... See full document
14
Herpes Simplex Virus 1 Ubiquitin-Specific Protease UL36 Inhibits Beta Interferon Production by Deubiquitinating TRAF3
... pseudorabies virus (PRV) (45), Marek’s disease virus (46), human cytomegalovirus (HCMV) (44, 47), murine cytomegalovirus (MCMV) (48), sim- ian cytomegalovirus (47), Epstein-Barr virus (EBV) (38), ... See full document
10
Gamma Interferon Can Prevent Herpes Simplex Virus Type 1 Reactivation from Latency in Sensory Neurons
... to inhibit reactivation of the latent virus and prevent recurrent disease appear more ...to inhibit HSV gene expression following stimuli such as stress, UV-B exposure, and hormonal ... See full document
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Independent and Cooperative Antiviral Actions of Beta Interferon and Gamma Interferon against Herpes Simplex Virus Replication in Primary Human Fibroblasts
...  1 and IFN- ␥ treatment coopera- tively induces the expression of genes for RNA degradation, apoptosis, and inflammatory ... 1 and IFN- ␥ , we were also inter- ested in how these two factors work ... See full document
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Ocular avirulence of a herpes simplex virus type 1 strain is associated with heightened sensitivity to alpha/beta interferon.
... 2187 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest BALB/c mice infected on the scarified cornea with herpes simplex virus type 1 strain 35 [HSV-135] rarely developed [r] ... See full document
6
Synergistic inhibition of human cytomegalovirus replication by interferon alpha/beta and interferon gamma
... with type I and type II IFNs renders cells non-permissive to HCMV replication in ...(Table 1, Figure ...HCMV replication in cells treated with IFN- α / β and IFN- γ was observed in both ... See full document
13
STAT4 Regulates Antiviral Gamma Interferon Responses and Recurrent Disease during Herpes Simplex Virus 2 Infection
... associated with the incidence of HSV-2 infection in humans. Like- wise, STAT4 deficiency did not affect either the viral load or dis- ease progression in primary HSV-2 infection in mice. This is somewhat different from ... See full document
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