[PDF] Top 20 Autoreactive T effector memory differentiation mirrors β cell function in type 1 diabetes
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Autoreactive T effector memory differentiation mirrors β cell function in type 1 diabetes
... the T cell populations to be studied were ...between T cell subsets and ther- apeutic effects of abatacept monotherapy in a clinical trial conducted by TrialNet ...between T cell ... See full document
16
Type I Interferon Signaling Enhances CD8+ T Cell Effector Function and Differentiation during Murine Gammaherpesvirus 68 Infection
... ⫹ T cells throughout later time points suggested possible ongoing interference with CD8 ⫹ T cell ...⫹ T cells to persistently high antigen levels, similar to that observed during chronic LCMV ... See full document
10
Islet transplantation in patients with autoimmune diabetes induces homeostatic cytokines that expand autoreactive memory T cells
... pathogenetic T cells and that such expansion could contribute to chronic or acute β cell loss, particularly if immunosuppression drug levels fall below those necessary to control effector ... See full document
10
Etiopathogenesis of type 1 diabetes mellitus: prognostic factors for the evolution of residual β cell function
... beta cell lesion, the more antigens are expressed, which will reactivate the ...regulatory T cells (T-regs) and effectors cells, and regeneration of beta cells up to the moment when the percentage of ... See full document
8
New insights into Blimp-1 in T lymphocytes: a divergent regulator of cell destiny and effector function
... + T cells can differentiate into Th1 and Th2 effector cells that secrete levels of IFN-γ, IL-4 and IL-10 similar to those produced by wild-type ef- fector cells, indicating that Blimp-1 is not ... See full document
17
Residual β cell function and monogenic variants in long duration type 1 diabetes patients
... the β cells newly formed since the onset of disease? The presence of scattered insulin-positive cells suggests an ongoing differentiation of new β cells rather than rep- lication of preexisting ...of ... See full document
13
Regulation of effector function of CNS autoreactive CD4 T cells through inhibitory receptors and IL-7Rα
... of T cell effector function have been well-established in T cell exhaustion, which was identified during chronic viral infection and observed in tumor ...of T cell ... See full document
12
Autoreactive CD8+ T cell exhaustion distinguishes subjects with slow type 1 diabetes progression
... Type 1 diabetes (T1D) is an organ-specific autoimmune disease that leads to the destruction of pancreatic islet β cells, resulting in glucose dysregulation and a life-long dependence on ... See full document
12
Anti thymocyte globulin/G CSF treatment preserves β cell function in patients with established type 1 diabetes
... preserve β cell function ...impaired β cell function ...preserving β cells and, as demonstrated by ATG and G-CSF, not all ineffective monother- apies should be discounted ... See full document
9
Autoreactive T cell responses show proinflammatory polarization in diabetes but a regulatory phenotype in health
... mediate, autoreactive T cells recognizing islet β cell peptides could represent both disease effectors in the development of type 1 diabetes (T1DM) and directors of ... See full document
14
Follicular helper T cell signature in type 1 diabetes
... target cell populations, including B cells, CD8 T cells, NK cells, and dendritic ...of diabetes (17, 18), while transgenic expression of IL-21 in the pancreatic islets was sufficient to induce ... See full document
13
Differential susceptibility of naïve, central memory and effector memory T cells to dendritic cell mediated HIV 1 transmission
... different T cell subsets is co- receptor expression. These HIV-1 transmission results with DC are in concordance with other studies that have shown in vivo and ex vivo the correlation between ... See full document
10
Unexpected positive control of NFκB and miR-155 by DGKα and ζ ensures effector and memory CD8 T cell differentiation
... in T cells has not been ...OT1 T cells increased miR-155 expression (Figure 9b), suggesting involvement of NFκB in activating miR-155 transcription in these ...in T cells, we differentiated WT and ... See full document
21
A Novel Single Cell FISH Flow Assay Identifies Effector Memory CD4+ T cells as a Major Niche for HIV 1 Transcription in HIV Infected Patients
... (11). Thus, we also explored the expression of CD32 in cells transcribing HIV in vitro and in vivo by our newly described method. We found that after ex vivo infection of unstimulated PBMCs, infected cells concomitantly ... See full document
18
Acquisition of full effector function in vitro paradoxically impairs the in vivo antitumor efficacy of adoptively transferred CD8+ T cells
... uncouples T cell proliferation from differentiation and preserves antitumor efficacy in ...optimal T cell populations for ACT are early effector cells that retain high levels of ... See full document
12
T cell-NF-κB activation is required for tumor control in vivo
... T cell-NF-κB is differently required for the elimination of distinct tissues in vivo, as it is essential for the rejec- tion of cardiac but not skin allografts, although the tempo of skin rejection is ... See full document
11
Signatures of CD8+ T cell dysfunction in AML patients and their reversibility with response to chemotherapy
... matched HCs (n = 4). (A) Hierarchical clustering of 453 DEGs between patients and HC (log 2 FC > 1 and < –1, and P < 0.01). Log 2 intensities are gene-wise Z transformed across all samples and ... See full document
21
Peroxiredoxin II Regulates Effector and Secondary Memory CD8+ T Cell Responses
... ⫹ T cell activation and differentiation is ...primary effector CD8 ⫹ T cell responses in PrdxII ⫺/⫺ mice was not sustained, immunological memory was maintained for ... See full document
13
Clinical characteristics and beta cell function in Chinese patients with newly diagnosed type 2 diabetes mellitus with different levels of serum triglyceride
... by β cell dysfunction. This may be attributed to that ex- cessive plasma TG lead to elevated levels of circulating free fatty acids (FFAs) which causes the impairment of the β cell ... See full document
7
Metabolism, migration and memory in cytotoxic T cells
... of effector CTLs to memory CD8 + T cells? One explanation could be the ability of rapamycin to reprogram the trafficking of effector CTLs such that these cells regain the ability to enter ... See full document
21
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