[PDF] Top 20 B cells in autoimmunity
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B cells in autoimmunity
... memory B-cell and plasma cell pool [16]. Moreover, the level of 9G4-expressing B cells as well as 9G4-containing anti- dsDNA antibodies is related to disease activity in SLE ... See full document
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Rituximab induces sustained reduction of pathogenic B cells in patients with peripheral nervous system autoimmunity
... autoantibodies binding to MAG antigen. Patients with anti-MAG neuropathy showed substantial clonal expansions of blood IgM memory B cells that recognized MAG antigen. The group of patients showing no ... See full document
11
Vitiligo after alemtuzumab treatmentSecondary autoimmunity is not all about B cells
... Alemtuzumab is an anti-CD52 antibody leading to rapid de- pletion followed by differential repopulation of B and T lymphocytes approved for the treatment of active relapsing- remitting multiple sclerosis (RRMS). ... See full document
6
Developing Connections among B Lymphocytes and Deregulated Pathways in Autoimmunity
... plasma cells that migrate from secondary lym- phoid organs to the bone marrow and have the potential to maintain robust serological memory for ...plasma cells is the transcription fac- tor B ... See full document
8
Role of perforin in controlling B cell hyperactivity and humoral autoimmunity
... of B-cell hyperactivity seen as early as 10 days after disease induction and occurs in nearly 100% of chronic GVHD mice ...host B cells did not differ significantly between the two groups (data not ... See full document
10
Ageing, autoimmunity and arthritis: Senescence of the B cell compartment – implications for humoral immunity
... above, B lymphopoiesis in aged animals has been studied as a function of production rate to determine whether the described defect in generative (or regenerative) capacity is confounded by cells that ... See full document
9
Activation of human B cells negatively regulates TGF-β1 production
... pressive B cell properties may be particularly relevant to the regulation of CNS ...anti-CD20-mediated B cell depletion has not yet been documented, increased proinflammatory monocytic activity following ... See full document
12
Is Graves’ disease a primary immunodeficiency? New immunological perspectives on an endocrine disease
... and B lym- phocytes and thus creates a drastic immunodeficient ...and autoimmunity are two sides of the same coin. Alemtuzumab-induced B cell depletion leads to a reactive increase in the B- ... See full document
15
Autoimmunity risk alleles: hotspots in B cell regulatory signaling pathways
... anergic B cells in check ...develop autoimmunity (18, ...with B cell– targeted knockout of SHP-1 (21) or SHIP-1 (22) as well as knockins of inactive TAPPs develop severe lupus-like disease ... See full document
5
T cells in the control of organ specific autoimmunity
... pathogenic cells, with the goal of “resetting” the immune system toward a more balanced homeostasis ...T cells, which are particularly resistant to deletion or suppression (135, 136), and suggests that ... See full document
12
Pathogenic antibodies are active participants in spinal cord injury
... of B cells and autoimmunity as contributing factors to poor neu- rological outcomes following spinal cord injury (SCI) is poorly ...that B cells produce pathogenic antibodies that ... See full document
5
Early B cell changes predict autoimmunity following combination immune checkpoint blockade
... circulating B cells before and after the first cycle of therapy in 39 patients with advanced melanoma receiving immune checkpoint blockade (23 received combina- tion therapy, 8 received anti-CTLA4, and 8 ... See full document
7
Diagnostic accuracy of blood B cell subset profiling and autoimmunity markers in Sjögren’s syndrome
... ipheral-blood B-cell subsets is profoundly altered in pa- tients with pSS. Memory B cells accumulate in target epithelial organs, and their proportion is decreased in peripheral blood ...naive ... See full document
6
Abnormalities of B cell phenotype, immunoglobulin gene expression and the emergence of autoimmunity in Sjögren's syndrome
... of B cells from the parotid gland, we found the frequency of S mutations to be increased, which was consistent with a reduced R/S ratio in the complementarity-determining regions (CDRs) ...of B ... See full document
12
T cell homeostasis and systemic autoimmunity
... T cells is controlled are not yet well ...effector cells (Figure ...of cells with high self-affinity, clinically evident autoaggression may be the ... See full document
7
JM2, encoding a fork head–related protein, is mutated in X linked autoimmunity–allergic disregulation syndrome
... X-linked autoimmunity–allergic disregulation syndrome (XLAAD) is an X-linked recessive immunological disor- der characterized by multisystem autoimmunity, particularly early-onset type 1 diabetes mellitus, ... See full document
8
Does autoimmunity against thyroglobulin play a role in the pathogenesis of Graves’ ophthalmopathy: a review
... The orbital reactions in patients with Graves’ disease are complex, involving antibodies and T lymphocytes, as well as other mononuclear cells, homing receptors on orbital cells, and cytokines. Moreover, we ... See full document
6
γδ T cells and NK cells – Distinct Pathogenic Roles as Innate Like Immune Cells in CNS Autoimmunity
... T cells, NKT, and innate lymphoid cells have been shown to be major sources of IL-17 in host control of a variety of bacterial, viral, and fungal ...Th17 cells, transfer of myelin antigen-specific ... See full document
6
Sonic Hedgehog regulates thymic epithelial cell differentiation
... Sonic Hedgehog (Shh) is expressed in the thymus, where it regulates T cell development. Here we investigated the influence of Shh on thymic epithelial cell (TEC) development. Components of the Hedgehog (Hh) signalling ... See full document
12
Initiation and Regulation of CNS Autoimmunity: Balancing Immune Surveillance and Inflammation in the CNS
... non-ramified cells during the inductive and peak phases of EAE was largely re- stricted to areas around blood vessels, whereas ramified ...CTLA-4+ cells near the blood vessels in the recovery phase of ...T ... See full document
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