[PDF] Top 20 The FUSE Binding Protein Is a Cellular Factor Required for Efficient Replication of Hepatitis C Virus
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The FUSE Binding Protein Is a Cellular Factor Required for Efficient Replication of Hepatitis C Virus
... the c-myc proto-oncogene (20, 32, 47). The c-myc transcription factor targets approximately 10% of transcribed genes and coordi- nates many essential cellular processes, including ... See full document
13
FUSE Binding Protein 1 Interacts with Untranslated Regions of Japanese Encephalitis Virus RNA and Negatively Regulates Viral Replication
... the C gene, followed by the foot-and-mouth disease virus 2A self-cleaving protease (FMDV 2A), to enable the cleavage of the luciferase away from downstream nonstruc- tural ...sequence required for ... See full document
9
Peptidyl-Prolyl Isomerase Pin1 Is a Cellular Factor Required for Hepatitis C Virus Propagation
... immunodeficiency virus (HIV) replication (29), HBV-mediated hepatocarcinogenesis (17), and human T cell leukemia virus type 1 (HTLV-1) ma- lignant transformation (7, ...cycle required Pin1, we ... See full document
12
Binding of Cellular Export Factor REF/Aly by Kaposi's Sarcoma-Associated Herpesvirus (KSHV) ORF57 Protein Is Not Required for Efficient KSHV Lytic Replication
... REF/Aly binding was required for ORF57 to enhance RNA stability, inde- pendent of any effects on RNA ...REF/Aly binding mutation on the ability of ORF57 to enhance PAN RNA ...nuclear cellular ... See full document
9
An RNA-Binding Protein, hnRNP A1, and a Scaffold Protein, Septin 6, Facilitate Hepatitis C Virus Replication
... exploit cellular proteins for their replication. We investigated cellular proteins that interact with NS5b because HCV may also rely on cellular machineries for its ...NS5b protein with ... See full document
14
Heparan Sulfate Proteoglycans Are Required for Cellular Binding of the Hepatitis E Virus ORF2 Capsid Protein and for Viral Infection
... chains required to bind distinct ligands differ from each other (23, ...of binding to HSPGs resides mostly in the sulfation pattern of the attached HS chains (14, 59, ...growth factor, 2-O sulfation ... See full document
11
Identification of Three Interferon-Inducible Cellular Enzymes That Inhibit the Replication of Hepatitis C Virus
... and C-terminal conserved domains of viperin in its antiviral ...radical protein superfamily is most pronounced in the C-terminal re- gion, which is responsible for binding of substrates and ... See full document
14
Identification of Residues Required for RNA Replication in Domains II and III of the Hepatitis C Virus NS5A Protein
... these cellular factors but failed to hinder HCV RNA ...replication. Cellular proteins have also been mapped to other larger interaction surfaces in domain III, including p53 and human TATA ... See full document
11
Impaired Replication of Hepatitis C Virus Containing Mutations in a Conserved NS5B Retinoblastoma Protein-Binding Motif
... not required for polymerase function per se but rather that the regulation of Rb by NS5B may have evolved as a mechanism to orchestrate cellular gene expression in such a manner as to create an ... See full document
12
DDX3 DEAD-Box RNA Helicase Is Required for Hepatitis C Virus RNA Replication
... DDX3 protein in DDX3 knockdown O cells (DDX3i#3) ...highly efficient knockdown of an unre- lated host factor, poly(ADP-ribose) polymerase 1 (PARP-1) (4), had no observable effects on HCV RNA ... See full document
5
The Cellular TATA Binding Protein Is Required for Rep-Dependent Replication of a Minimal Adeno-Associated Virus Type 2 p5 Element
... p5-dependent replication. We finally asked whether overexpression of this cellular factor could enhance the Rep-dependent replication of the minimal p5 ...Enhanced binding of Rep68 to ... See full document
13
Poly(C)-Binding Protein 2 Interacts with Sequences Required for Viral Replication in the Hepatitis C Virus (HCV) 5′ Untranslated Region and Directs HCV RNA Replication through Circularizing the Viral Genome
... tiple cellular RNA-binding ...host protein known to bind to the 5 ⬘ UTR of the poliovirus genome, regulates the switch between poliovirus translation and replication ...the cellular ... See full document
11
Viral and Cellular Determinants of Hepatitis C Virus RNA Replication in Cell Culture
... the replication of hepatitis C virus (HCV) have been facilitated by the development of selectable subgenomic replicons replicating in the human hepatoma cell line Huh-7 at a surprisingly high ... See full document
13
Determination of the secondary structure of and cellular protein binding to the 3'-untranslated region of the hepatitis C virus RNA genome.
... Hepatitis C virus (HCV) contains a positive-stranded RNA genome of approximately ...RNA replication involving possibly both viral and cellular ...detect cellular proteins that ... See full document
9
EWSR1 Binds the Hepatitis C Virus cis-Acting Replication Element and Is Required for Efficient Viral Replication
... The hepatitis C virus (HCV) genome contains numerous RNA elements that are required for its ...cis-acting replication element (CRE), is located within the NS5B coding ...is ... See full document
10
Identification of GBF1 as a Cellular Factor Required for Hepatitis C Virus RNA Replication
... BFA-sensitive factor required for HCV replica- ...viral factor. The best-documented cellular targets of BFA are members of the ARF ...exchange factor 1 (BIG1), BIG2, or Golgi BFA ... See full document
15
FUSE Binding Protein 1 Facilitates Persistent Hepatitis C Virus Replication in Hepatoma Cells by Regulating Tumor Suppressor p53
... FBP1 is expressed in HCC tumors with a history of chronic hep- atitis C. Earlier, we showed that FBP1 is an essential cell factor for HCV replication (10). In an immunochemical analysis of 109 HCC ... See full document
18
Interactome Analysis of the Influenza A Virus Transcription/Replication Machinery Identifies Protein Phosphatase 6 as a Cellular Factor Required for Efficient Virus Replication
... A virus life cycle, siRNA-mediated knockdown of the PP6 catalytic sub- unit was performed and growth of influenza A virus was ...PPP6C protein levels to 5 to 20% of the untreated level ...PB2-Strep ... See full document
16
Conserved GXXXG- and S/T-Like Motifs in the Transmembrane Domains of NS4B Protein Are Required for Hepatitis C Virus Replication
... transmembrane protein, its puta- tive TMDs contribute to at least one-third of the protein ...the protein via intramolecular ...folding protein, NS4B may need intermolecular interactions in ... See full document
16
HuR Displaces Polypyrimidine Tract Binding Protein To Facilitate La Binding to the 3′ Untranslated Region and Enhances Hepatitis C Virus Replication
... HCV-JFH1 virus. (C) A GST pulldown assay was performed by incubating GST- or GST-HuR-coated beads with Huh7 or replicon cell lysates as ...NS5B protein was detected by Western blotting (WB) using ... See full document
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