[PDF] Top 20 Brain atrophy in Multiple Sclerosis
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Brain atrophy in Multiple Sclerosis
... neocortical atrophy was a prominent feature of relapsing remitting MS (RRMS), and suggested that neocortical atrophy occurs in the earliest stages of MS and is even seen when white matter lesion ... See full document
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The neutrophil-to-lymphocyte and monocyte-to-lymphocyte ratios are independently associated with neurological disability and brain atrophy in multiple sclerosis
... whole brain atrophy and also with male gender, the latter being a well-known risk for more rapid disability accumulation ...and brain atrophy outcomes, also reflects current thinking in the ... See full document
10
The role of MR volumetry in brain atrophy assessment in multiple sclerosis: A review of the literature
... in multiple sclerosis (MS) ...of brain atrophy evaluation. Evidence shows that measures of brain volume (BV) have the potential to be an important determinant of disease progression to ... See full document
11
A regional consensus recommendation on brain atrophy as an outcome measure in multiple sclerosis
... assessing brain atrophy in patients with MS, discuss the relevant parts of the brain in terms of disease pro- gression with ...tiple sclerosis’ AND ‘brain ...in Multiple ... See full document
9
Whole Brain Atrophy in Multiple Sclerosis Measured by Automated versus Semiautomated MR Imaging Segmentation
... segment brain tissue into gray, white, and CSF compartments (Fig ...plane. Brain im- ages were aligned by matching the interhemispheric fissure to the origin’s x- and y-axis in the anteroposterior and ... See full document
12
Brain atrophy in multiple sclerosis: mechanisms, clinical relevance and treatment options
... Pathogenesis of acute demyelination and axonal injury In the initial stages of MS, many different components of the adaptive and the innate immunity induce demy- elination and neuronal loss [43]. The activation of auto- ... See full document
25
Regional Brain Atrophy Evolves Differently in Patients with Multiple Sclerosis According to Clinical Phenotype
... that atrophy in these regions is typical of the disease, as it was de- tected in all groups studied and it tends to be more evident in the progressive ...regional brain tissue loss was observed in healthy ... See full document
6
Effects of disease modifying therapies on brain and grey matter atrophy in relapsing remitting multiple sclerosis
... These findings are particularly worth of interest since a previous multicentre, randomized, double blind, pla- cebo controlled study in RRMS patients having longer disease duration, failed to demonstrate any impact of GA ... See full document
10
Regional Lobar Atrophy Predicts Memory Impairment in Multiple Sclerosis
... Neuropsychological testing conformed to consensus panel recommendations (32) regarding the assessment of processing speed and memory. Rao adaptations (33, 34) of the Paced Auditory Serial Addition Test (35) and the ... See full document
8
T1- vs. T2-based MRI measures of spinal cord volume in healthy subjects and patients with multiple sclerosis
... cord volume and MS disability [2, 5–10]. Spinal cord imaging is routine in MS care and provides unique and complementary information on disease severity that is not captured by brain MRI [8, 11, 12]. However, the ... See full document
6
Quantitative determination of MS induced corpus callosum atrophy in vivo using MR imaging
... To quantitate the extent of corpus callosum atrophy in multiple sclerosis, midsagittal corpus callosum areas were determined in 48 controls with normal MR scans and 41 patients with defi[r] ... See full document
6
Perk Genetic Variation and Function in Progressive Supranuclear Palsy
... lateral sclerosis, multiple system atrophy, and in the hippocampus and substantia nigra of PSP ...disease-affected brain regions in both ... See full document
110
Spatial Correlation of Pathology and Perfusion Changes within the Cortex and White Matter in Multiple Sclerosis
... GM atrophy and pathology in anatomically connected WM tracts in patients with RRMS, SPMS, and primary-progres- sive MS, demonstrating a relationship between NAWM tract frac- tional anisotropy and deep GM and ... See full document
6
Bi-caudate ratio as a MRI marker of white matter atrophy in multiple sclerosis and ischemic leukocencephalopathy
... matter atrophy may be significantly correlated with progressive impairment of the cognitive functions in white matter leukodystrophies ...in brain volume through a qualitative inspection of brain MRI ... See full document
6
Severe brain atrophy in the elderly as a risk factor for lower respiratory tract infection
... severe brain atrophy, type of brain atrophy (cortical atrophy of each lobe, the four cortical sulci ratio, Evans ratio, and the third ventricular ratio), and the pres- ence of diffuse ... See full document
7
Subcortical and Cortical Gray Matter Atrophy in a Large Sample of Patients with Clinically Isolated Syndrome and Early Relapsing Remitting Multiple Sclerosis
... MATERIALS AND METHODS: Two hundred twelve patients with CIS recruited at the first clinical event (mean age, 29.3 years; median EDSS, 1.5; median disease duration, 3 months) and 177 patients with early RRMS (mean age, ... See full document
6
Comparison of Three Different Methods for Measurement of Cervical Cord Atrophy in Multiple Sclerosis
... cord atrophy (CCF and CCAV/ICV). CCAV was the best cervical cord atrophy predic- tor for characterizing differences between NCs and MS pa- tients and between different disease subtypes (Table 3), fol- lowed ... See full document
7
An Atypical Presentation of Multiple Sclerosis
... MRI Brain report: A mildly expansile lesion in the medulla which could represent demyelination, infarct or low grade glioma. MR Spectroscopy was advised for confirmation. Patient was then started on intravenous ... See full document
5
Reproducibility of Three Whole Brain N Acetylaspartate Decline Cohorts in Relapsing Remitting Multiple Sclerosis
... In a previous study we have shown 3 differential strata of whole-brain NAA (WBNAA) decline rates, 23 which probably reflect axonal dysfunction, in 49 clinically similar relapsing- remitting (RR) MS patients. Based ... See full document
5
Evaluation of both perfusion and atrophy in multiple system atrophy of the cerebellar type using brain SPECT alone
... The present results of significant perfusion decreases in the cerebellum and pons of the MSA-C patients are the same as those noted in a previous report using SPM ana- lysis of SPECT data with conventional warping [7]. ... See full document
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