[PDF] Top 20 Cannabinoids versus placebo or no intervention for pain: protocol for a systematic review with meta-analysis and trial sequential analysis

... a systematic review of randomised clinical trials with meta- analysis and Trial Sequential Analysis to assess the beneficial and harmful effects of cannabinoids in ... See full document

... Cochrane review from 2015 [61] assessed the com- parison of prothrombin complex concentrate with fresh frozen ...this review did not specifically assess the effects of prothrombin complex concentrate ... See full document

... Cumulative meta-analyses are at risk of producing ran- dom errors due to sparse data and multiple testing of ac- cumulating data [64, ...Therefore, Trial Sequential Analysis [64] can be ... See full document

... chronic pain conditions in both treatment and control ...of pain provided by the International Association for the Study of Pain, which states that pain is an ‘unpleasant sensory and emotional ... See full document

... for Systematic Reviews of Interventions ...in meta-analyses of pain-related studies, and a modified form has also been used ...the intervention used were removed, since that type of medical ... See full document

... perform trial sequential analyses on the outcomes, in order to control the risks of type I and type II errors that occur in traditional meta-analyses due to sparse data and repetitive analyses of ... See full document

... treat analysis to trials with high risk of bias according to these ...group versus individ- ual exercise will be assessed by comparing trials using group exercises compared to trials using individual exer- ... See full document

... Cumulative meta-analyses are at risk of producing random errors due to sparse data and multiple testing of accumulating data [32, ...realistic intervention effect in a meta-analysis and the ... See full document

... the meta-analysis ac- cording to the recommendations stated in the Cochrane Handbook for Systematic Reviews of Interventions [83], Keus et ...our intervention effects with both random-effects ... See full document

... used placebo as control intervention and due to the large number of adverse events, some patients might have figured out if they received an ‘active’ interven- tion or not, which might question the blinding ... See full document

... 2013 trial is that sham cigarettes contained cannabis sativa flowers in which active cannabinoids had been ...2013 trial demonstrated a significant reduction in pain and the use of steroid ... See full document

... conventional meta-analysis showed no difference in mortality in patients treated with dornase alfa compared with the control group: random effects model RR (95 % CI) ...subgroup analysis of trials ... See full document

... Apart from the detection efficiency of prostate biopsy, complications also play an important role in evaluating the safety and value of the biopsy method. Our study re- vealed that the TP approach significantly decreased ... See full document

... Exercise intervention might be beneficial to the patients with osteoporotic vertebral frac- ...a systematic review and meta-analysis to explore the effect of exercise ... See full document

... The IOP lowering-effect of 180-degree SLT was equivalent to 180-degree ALT in those who had 360-degree SLT before. The difference of mean IOP reduction between the two treatment groups was -0.01 mmHg (95% CI, -1.86 to ... See full document

... model meta-analyses, it is too simplistic to just increase the required informa- tion size with the variance increase, going from a fixed- effect to a random-effects ...model meta-analysis becomes ... See full document

... this meta-analysis include the following: the inclusion of patients only during the acute phase, which did not enable us to analyze the long-term efficacy and safety of Vortioxetine in treating major de- ... See full document

... this review, as it will only involve the collation of previously published liter- ...This systematic review will collect and collate results from the numerous studies which have investi- gated ... See full document

... The analysis of this work shows that the interscale- nic block is the technique that allows a better analgesia, with a lower VAS score and a lower demand for rescue analgesic ...VAS pain and the detected ... See full document

... Community engagement and health interventions overlap each other conceptually and operationally, with several dimensions of community engagement approaches being used for health interventions. These included the de fi ... See full document