[PDF] Top 20 Catalytic organometallic anticancer complexes
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Catalytic organometallic anticancer complexes
... obtain complexes 3-10, using the corresponding diamine ligand and osmium arene chlorido ...osmium complexes proved highly stable under storage in both atmospheric air and aqueous ...Os(II) complexes ... See full document
275
Organometallic iridium(III) anticancer complexes with new mechanisms of action: NCI 60 screening, mitochondrial targeting, and apoptosis
... Ir complexes by changing the chelating ...these complexes, potentially increasing ROS, damaging DNA, and disrupting protein ...these complexes, where perhaps the primary MoA is redox mediation, ... See full document
10
Design of catalytic organometallic anti cancer drugs
... a catalytic anticancer drug. In an ideal situation the complexes will not show antiproliferative activity towards cancer cells unless activated upon reaction with sodium ...the complexes 1-3 ... See full document
302
Cyclic peptide–polymer nanotubes as efficient and highly potent drug delivery systems for organometallic anticancer complexes
... The well-studied monomer building block 2-hydroxypropyl methacrylamide (HPMA) was chosen as the main monomer for designing the polymeric drug used in this work. In order to provide a binding site for the ligation of ... See full document
27
Mirror image organometallic osmium arene iminopyridine halido complexes exhibit similar potent anticancer activity
... high correlation coefficient with known drugs have generally been found to have similar mechanisms of action. High correlation (1 0.6) to a spe- cific standard agent indicated a similar anticancer mechanism of ... See full document
12
Contrasting anticancer activity of half sandwich iridium(III) complexes bearing functionally diverse 2 phenylpyridine ligands
... All complexes hydrolyze rapidly at 310 K, but total suppression of aquation can be achieved with 4 mM NaCl, implying that under physiological conditions the complexes would exist as the neutral chlorido ... See full document
13
Metal complexes as DNA intercalators
... (37) Wang, F. Y.; Xu, J. J.; Habtemariam, A.; Bella, J.; Sadler, P. J. Competition between glutathione and guanine for a ruthenium(II) arene anticancer complex : detection of a sulfenato intermediate. J. Am. Chem. ... See full document
46
Photoactivatable organometallic pyridyl ruthenium(II) arene complexes
... other complexes so that their generation is ...potential anticancer agents with discriminating preference towards ...pyridine-derivative complexes, studies on CT-DNA interactions in cell-free media ... See full document
48
Schiff base metal complexes of Ni, Pd and Cu
... its complexes with ...metal complexes are widely studied because of their industrial, antifungal, antibacterial, anticancer and herbicidal ...metal complexes have been identified as effective ... See full document
11
The odd nature of main group organometallic polyynes complexes
... independent catalytic cycles: the “palladium cycle” and the “copper cycle” (Scheme ...palladium catalytic cycle is oxidative addition of the organohalide species, which is considered to be the rate–limiting ... See full document
285
Hydroxide complexes of the late transition metals : organometallic chemistry and catalysis
... but catalytic quantities could be used (15 mol%) (Scheme ...putative catalytic trifluoromethylation reaction using readily‐available fluoroform as the CF 3 ... See full document
34
One-step templated synthesis of chiral organometallic salicyloxazoline complexes
... oxazolinyl organometallic complexes are very important catalysts in organic chemistry ...Several organometallic complexes containing 2-(2 ′ -hydroxyphe- nyl)oxazolines are reported in the ... See full document
9
Organoiridium complexes : anticancer agents and catalysts
... * complexes, for example, can take place in ...half-sandwich organometallic Ir III anticancer agents has ...and catalytic reactions involving, for example, hydrogen production, quinone ... See full document
13
Functionalization of osmium arene anticancer complexes with (poly)arginine : effect on cellular uptake, internalization, and cytotoxicity
... reported organometallic osmium(II) arene complexes with promising cancer cell cytotoxicity ...these complexes have been shown to induce non-repairable damage to DNA by causing a large degree of DNA ... See full document
36
Organometallic iridium(III) cyclopentadienyl anticancer complexes containing C,N chelating ligands
... methods. Complexes 2 and 5 were refined against F 2 using SHELXL 9 , and hydrogen atoms were added at calculated positions and refined riding on their parent ... See full document
30
Organometallic osmium arene anticancer complexes
... three complexes (3, 6 and 12) were selected for further evaluation against a cisplatin-resistant sub-line of A2780, A2780/cis, and also against a panel of human cancer cell lines of differing ...histiotype. ... See full document
262
Organometallic half sandwich iridium anticancer complexes
... arene complexes to Ir III Cp* and functionalized Cp* complexes [(η 5 -Cp x )Ir(XY)Cl] 0/+ containing N,N-bound 1,10-phenanthroline (phen), 2,2′-bipyridine (bpy), ethylenediamine (en), and N,O-bound ... See full document
54
Design and mechanism of action of organometallic anticancer complexes
... piano-stool complexes similar to those of Ru(II), complexes such as [Os(η 6 -bip)(en)Cl] + or [Os(η 6 -bip)(picolinate)Cl] which have shown to have good activity against A2780 ovarian cancer ...Os ... See full document
345
Organometallic iridium anticancer complexes
... Organometallic complexes offer enormous scope for the design of anticancer candidates due to their versatile structures, potential redox features and wide range of ligand substitution ...Iridium ... See full document
259
New activation mechanism for half sandwich organometallic anticancer complexes
... N,N 0 -chelated ligand (en, bpy, mbpy or phen), and a mono- dentate chloride ligand were synthesized by the reaction of the appropriate chloride-bridged dimer and chelating ligand, except complex 12 which was prepared by ... See full document
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