[PDF] Top 20 CD147 increases mucus secretion induced by cigarette smoke in COPD
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CD147 increases mucus secretion induced by cigarette smoke in COPD
... that CD147 also modulates the phosphorylation of p38 MAPK ...of CD147 in regulating inflammatory responses in a variety of dis- eases, including lung inflammation ...of CD147 were high in COPD ... See full document
10
Effect of simvastatin on MMPs and TIMPs in cigarette smoke-induced rat COPD model
... of cigarette smoke-induced ...blocked cigarette smoke-induced MMP-8 and -9 protein syn- thesis, but also significantly stimulated TIMP-1 and -4 protein synthesis in the presence ... See full document
8
Günter, Stefanie (2017): The effect of immunoageing on the susceptibility to cigarette smoke induced COPD. Dissertation, LMU München: Medizinische Fakultät
... in COPD patients compared to healthy non smoking as well as smoking control subjects has been ...old smoke exposed ...old cigarette smoke exposed mice compared to both the respective filter ... See full document
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Original Article Simvastatin mitigates functional and structural impairment of lung and right ventricle in a rat model of cigarette smoke-induced COPD
... of COPD was first established through a protocol modified by a 4-month chal- lenge for the rats exposed to a high level of smoking (20 cigarettes, twice a day) in a smok- ing ...of COPD-like lesion in the ... See full document
10
Impact of fatty acid binding protein 5-deficiency on COPD exacerbations and cigarette smoke-induced inflammatory response to bacterial infection
... Being at the interface between the host and the envi- ronment, the airway epithelium represents the first line of host defense against potential pathogens or irritants (such as cigarette smoke). This ... See full document
11
Immunological Features of Chronic Obstructive Pulmonary Disease (COPD) Induced by Indoor Pollution and Cigarette Smoke
... the cigarette smoke-activated immune system produces the classic pathological symptoms of COPD ...by cigarette smoke release a number of danger signals (PAMPs) that can result in the ... See full document
12
Original Article Ginsenoside Rg1 alleviates pulmonary inflammation caused by cigarette smoke-induced COPD
... of COPD, and toxic compounds present in cigarette smoke cause their infiltration into the airways, which eventually induce patho- physiological alterations in lung tissue ...with COPD [26, ... See full document
8
<p>Exercise Ameliorates Emphysema Of Cigarette Smoke-Induced COPD In Mice Through The Exercise-Irisin-Nrf2 Axis</p>
... to cigarette smoke once a ...evaluate cigarette smoke-induced COPD, the number of in fl ammatory cells in bronchoalveolar lavage fl uid (BALF), mean linear intercept (MLI), and ... See full document
10
Reduced nuclear translocation of serum response factor is associated with skeletal muscle atrophy in a cigarette smoke-induced mouse model of COPD
... Cigarette smoke (CS) is the primary risk factor of chronic obstructive pulmonary disease (COPD). CS exposure contributes not only to the development of irrevers- ible lung damage but also to the ... See full document
7
Hydrogen coadministration slows the development of COPD-like lung disease in a cigarette smoke-induced rat model
... Expression of proteins such as TNF- α , IL-6, IL-17, IL-23, MMP-12, TIMP-1, caspase-3, and caspase-8 (IHC, Figures 6 and 7; WB, Figure 8) was detected by IHC and WB of the lung tissue. Expression of TNF- α , IL-6, IL-17, ... See full document
16
Inflammaging increases susceptibility to cigarette smoke- induced COPD
... involved in emphysema development [6], although little is known about the causative formation of such structures. Histological analysis of lung sections from 3 months CS-exposed young and old mice revealed a strong ... See full document
16
<p>Fine-particulate matter aggravates cigarette smoke extract–induced airway inflammation via Wnt5a–ERK pathway in COPD</p>
... significantly in mice after PM 2.5 and smoking exposure, respectively, becoming even more pronounced after joint exposure to PM 2.5 and smoking. In 16HBE cells, PM 2.5 and CSE exerted similar effects on the ERK pathway ... See full document
16
Cigarette smoke-induced lung inflammation in COPD mediated via LTB4/BLT1/SOCS1 pathway
... Methods: SOCS1 expression in bronchial mucosa was determined by immunohistochemistry and real-time polymerase chain reaction. We also detect SOCS1 and BLT1 expression in alveolar macrophages from bronchoalveolar lavage ... See full document
11
Physical exercise is effective in preventing cigarette smoke-induced pulmonary oxidative response in mice
... injury induced by cigarette smoke (CS) exposure, and physical exercise (Ex) is useful in com- bating impaired oxidative ...markers induced by ...exercise, cigarette smoke, ... See full document
8
Role of CCR5 in IFN γ–induced and cigarette smoke–induced emphysema
... with COPD (13, 14, 16, 18, 22, 23) and our studies demonstrating that IFN-g causes protease-antiprotease abnormalities and emphysema in the murine lung (19), it has been assumed that the Th1/Tc1 inflammatory ... See full document
14
MAPK/FoxA2-mediated cigarette smoke-induced squamous metaplasia of bronchial epithelial cells
... Forty rats were randomly divided into a blank control group, a CS group, a smoking + U0126 group, a smoking + SB203580 group, and a smoking + SP600125 group. Inhalation was used to establish the COPD animal model ... See full document
11
Endoplasmic reticulum chaperone GRP78 mediates cigarette smoke-induced necroptosis and injury in bronchial epithelium
... Inflammatory cytokines interleukin 6 (IL6) and IL8 have been involved in the pathogenesis of COPD. In HBE cells, CSE exposure time dependently increased the mRNA lev- els of IL6 and IL8 (Figure 3A and B). We next ... See full document
11
The role of cigarette smoke-induced epigenetic alterations in inflammation
... 5) COPD showed that, in smokers without COPD, 87 lncR- NAs were significantly upregulated and 244 were down- regulated compared to the lncRNAs expressed in the nonsmokers ...with COPD, 120 lncR- NAs ... See full document
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<p>Necroptosis Mediates Cigarette Smoke-Induced Inflammatory Responses in Macrophages</p>
... of COPD, 8 and we also found that necroptosis plays an important role in CS-induced airway ...to COPD pathogen- ...in COPD have yet to be ... See full document
9
Immune-regulating effects of exercise on cigarette smoke-induced inflammation
... Recent data suggest that airway epithelial cells (AECs) which represent a first line of defense against inhaled toxicants have altered inflammatory signaling in response to CS exposure. These cells were shown to ... See full document
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