[PDF] Top 20 Cellular RNA Helicase DHX9 Interacts with the Essential Epstein-Barr Virus (EBV) Protein SM and Restricts EBV Lytic Replication

... of DHX9 depletion on EBV lytic gene expression and ...of DHX9 led to increased infectious EBV virion production, we per- formed further experiments to investigate which steps of the ... See full document

... The Epstein-Barr virus transactivator Zta triggers lytic gene expression and is essential for replication of the lytic origin, ...a replication- specific ...domain ... See full document

... Conversely, SM would have relatively little effect on the levels of transcripts that are constitutively well ...by cellular RNA-binding ...Although SM has been shown to exert ... See full document

... that SM induces expression of the human protein Sp110b and that SM interacts directly with Sp110b in vitro and in ...bind SM were mapped. Binding of Sp110b to SM was found to be ... See full document

... The Epstein-Barr virus (EBV) SM protein is essential for lytic EBV DNA replication and virion ...When EBV replication is induced in ... See full document

... ABSTRACT Epstein-Barr virus (EBV) SM protein is an essential lytic cycle protein with multiple posttranscriptional mechanisms of ...action. SM binds ... See full document

... ABSTRACT Epstein-Barr virus (EBV) is linked to the development of both lymphoid and epithelial malignancies ...of EBV, isolated from a Chi- nese patient with nasopharyngeal carcinoma ... See full document

... of EBV infection on levels of miR200 family members and the ...by EBV alters the balance between the levels of the ZEBs and miR200 family members, possibly in a cell-type- dependent manner, thereby ... See full document

... 2001 SM is an Epstein-Barr virus (EBV) gene expressed during early lytic replication of ...EBV. SM encodes a nuclear phosphoprotein that functions as a ... See full document

... DNA replication is not thought to occur in cells destined for immortalization, and no virus is produced in the immortalized ...The EBV latent gene product, EBNA3C (also called EBNA6), has been ... See full document

... 2010 Epstein-Barr virus (EBV) SM protein is an essential nuclear protein produced during the lytic cycle of EBV ...replication. SM is an ... See full document

... 2009 Epstein-Barr virus (EBV) SM protein is an essential nuclear shuttling protein expressed by EBV early during the lytic phase of ... See full document

... viral replication was not solely linked to its capacity to activate ...Rta interacts with oriLyt in ...supporting lytic viral DNA replication in the presence of ZEBRA mutants that are ... See full document

... RB2 protein products have not yet been ...fusion protein, in vitro-translated RK-BARF0, and transfected RK-BARF0 ...a cellular protein that was expressed at high levels in the ... See full document

... core protein of hepatitis C virus (HCV) has been shown to trans-act on several viral or cellular ...core protein, a yeast two-hybrid cloning system was used for identification of core ... See full document

... with replication foci identified by Cy3-dUTP pulse-labeling and immunostaining for PCNA in early-middle S ...Cy3-dUTP-pulse-labeled replication foci in synchronously cultured fixed CHO-K1 cells in early ... See full document

... the EBV early proteins SM and M, which appear to act posttranscriptionally and are homologs of herpes simplex virus (HSV) ICP27, might compensate for the inefficient processing of pol ...the ... See full document

... BZLF1 protein (amino acid 200), which prevents in vitro interaction with the BMRF1 protein but which does not reduce BZLF1 transactivator function, allows the BZLF1 protein to activate the BMRF1 ... See full document

... the virus infects its primary host target cell — the human B cell — by binding to complement receptors 1 and 2 as well as MHC class II as a co-receptor 8,9 ...the virus is transferred across the mucosal ... See full document

... complement EBV(gp1102) 1 ...viable virus, the mutations in the gp110 tail domain define a novel do- main essential for the production of infectious virus which is not contained in HSV-1 ...of ... See full document