[PDF] Top 20 Cellular interactions in the pathogenesis of interstitial lung diseases

... the lung originate from existing vessels through angiogenesis ( proliferation and migration of existing endothelial cells), but it has been shown that vasculogenesis (new development of vessels by stem or ... See full document

... In this work we analyzed the role of HA in the migration of inflammatory cells. Our results suggest that AH could contribute to the recruitment of macrophages and monocytes through a CD44-dependent process leading to ... See full document

... in lung function and, eventually, early ...regarding pathogenesis and clinical behaviour, they are increasingly described under the umbrella terminology of “ progressive fibrosing ILDs ” (PF-ILDs) or “ ... See full document

... Environmental endotoxin when respired may trigger either the innate or adaptive immunity, depending on concentration and time of exposure [14]. The endotoxin in BALf could therefore reflect a role of air-borne LPS (e.g. ... See full document

... to lung biopsy for diagnosis. IPF patients have lung pathology consistent with a UIP pattern, characterised by interstitial fibrosis, honeycomb changes, fibroblastic foci and a paucity of ... See full document

... and cellular debris are ineffectively cleared and accumulate in the ...in cellular housekeeping mechanisms leads to senescence or apoptosis [46, 58, ...of cellular components via the lysosomal ... See full document

... the pathogenesis of IPF [34 – 36], and the latter has been demonstrated in a randomised controlled trial (RCT) (the TIPAC trial) to improve quality of life and, in the per-protocol analysis, to reduce all-cause ... See full document

... of interstitial lung diseases (ILDs), particularly in idiopathic pulmonary fibrosis and ILD associated with connective tissue ...other lung diseases, such as combined pulmonary fibrosis ... See full document

... characteristic pattern of disease behaviour. However, our understanding of the pathogenesis of IPF has evolved significantly [1]. The currently favoured model of disease is an epithelial-driven and ... See full document

... the lung parenchyma may lead to thickening of the alveolar septa or filling of alveolar spaces with granu- lation tissue and subsequent ...of lung injuries, including neonatal hyperoxia, adult respiratory ... See full document

... The cellular pattern of NSIP is characterized by mild to moderate interstitial chronic inflammation and type 2 AEC hyperplasia in inflammation ...tissues diseases and surfactant ...alveolar ... See full document

... parenchymal lung diseases, which may be secondary to a variety of occupational or environmental exposures, or – as discussed in the present review – can complicate multiple rheumatic or connec- tive tissue ... See full document

... HRCT can be used to identify different types of ILDs, even to the level of subclassification of CTD-ILDs and staging of early versus progressive disease (figure 1) [25 – 27]. A UIP pattern can be observed in some ... See full document

... the lung lose elastic recoil and therefore do not change appreciably in volume between inspiration and ...by lung parenchymal areas that are not emphysematous but which fail to increase in attenuation (or ... See full document

... suspected diseases simultaneously and directly from the chest radiograph, which conforms to the principles of radiolo- gists’ interpretation of the ...classify diseases by extracting the features from the ... See full document

... AE of ILDs that may present a progressive-fibrosing phenotype is an unpredictable serious life-threatening event that can occur at any time during the disease course. Data on the incidence of AE in ILDs that may present ... See full document

... ABSTRACT Multidisciplinary team (MDT) diagnosis is regarded as the diagnostic reference standard for interstitial lung disease (ILD). Several studies have reported that MDT diagnosis is associated with ... See full document

... the lung architecture 60 ...by interstitial fibrosis exceeding the fine fibrosis often seen in emphysema ...chronic interstitial pneumonia such as UIP or nonspecific ... See full document

... [113]. A detailed analysis showed that these responses were dependent on bacterial flagellin and TLR5 expres- sion. Peripheral blood mononuclear cells from CF patients also responded more vigorously to stimulation with ... See full document

... We next wished to extend these findings to tissues of animals with diseases of protein misfolding in the ER. First, we looked directly at the rescue of mutant rdw-Tg3xMyc in thyroid tissue from animals lacking or ... See full document