[PDF] Top 20 Characterization and modulation of autoreactive CD4+ T cells in type 1 diabetes
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Characterization and modulation of autoreactive CD4+ T cells in type 1 diabetes
... activated CD4 + T cells alone transfer diabetes to irradiated NOD or ...of CD4 + T cells in NOD mice via anti-CD4 antibody treatment at early and late preclinical ... See full document
173
Impairment of Human Immunodeficiency Virus Type 1 (HIV-1) Entry into Jurkat T Cells by Constitutive Expression of the HIV-1 Vpr Protein: Role of CD4 Down-Modulation
... A number of studies have shown that Vpr, imported by the virion (17), newly synthesized (14, 25), or exogenously added (19), can positively regulate HIV replication in different cell types. In this report, we studied the ... See full document
5
Macrophage IFN-I signaling promotes autoreactive T cell infiltration into islets in type 1 diabetes model
... Type I IFN (IFN-I) are pleiotropic cytokines that induce potent antiviral programs to protect the host from microbial infections, but they also potentiate the diabetogenic process of β cell destruction ... See full document
14
CD4 down-modulation during infection of human T cells with human immunodeficiency virus type 1 involves independent activities of vpu, env, and nef.
... with CD4 1 cells ...infected T lymphocytes survive only 2 days following infection in vivo (14, ...in CD4 2 cells may be a result of the short average lifetime of a produc- ... See full document
10
Thymus specific serine protease controls autoreactive CD4 T cell development and autoimmune diabetes in mice
... nonhematopoietic cells could lead to disease ...diabetogenic T cell specificities by TECs lacking Tssp, although one cannot exclude that, under such conditions, negative selection, driven either directly by ... See full document
13
CD4 Down-Modulation by Human Immunodeficiency Virus Type 1 Nef Correlates with the Efficiency of Viral Replication and with CD4+ T-Cell Depletion in Human Lymphoid Tissue Ex Vivo
... of CD4 cell surface ex- pression are still capable of enhancing virion ...indicator cells did not correlate with the replicative capacity in PBMC or ...between CD4 down-regulation and the efficiency ... See full document
5
Autoreactive T effector memory differentiation mirrors β cell function in type 1 diabetes
... thawed, cells were transferred from the cryovial to a 30-ml ...the cells while the tube was gently ...with 1 ml thaw media and added drop-wise to the tube. Cells were centrifuged at 200 g for ... See full document
16
Suppression of autoimmune disease after vaccination with autoreactive T cells that express Qa 1 peptide complexes
... of autoreactive T cells to provoke autoimmune disease is well ...attenuated autoreactive T cells (T cell vaccination, or TCV) can induce T cell–dependent inhibi- ... See full document
8
Contribution of Vpu, Env, and Nef to CD4 Down-Modulation and Resistance of Human Immunodeficiency Virus Type 1-Infected T Cells to Superinfection
... protect cells against superinfection by down-modulating both CD4 and the coreceptor R5 ...clone, modulation of R5 should not affect superinfection resistance in our ...on CD4 and X4, we ... See full document
13
Regulation of effector function of CNS autoreactive CD4 T cells through inhibitory receptors and IL-7Rα
... of T cell effector function have been well-established in T cell exhaustion, which was identified during chronic viral infection and observed in tumor ...of T cell exhaustion, although multiple ... See full document
12
Autoreactive CD8+ T cell exhaustion distinguishes subjects with slow type 1 diabetes progression
... Type 1 diabetes (T1D) is an organ-specific autoimmune disease that leads to the destruction of pancreatic islet β cells, resulting in glucose dysregulation and a life-long dependence on ... See full document
12
Characterization and immunomodulation of regulatory T cells in Type 1 diabetes
... of Type 1 diabetes (T1D) is the T cell mediated destruction of the insulin- producing β cells in the pancreatic islets ...immunoregulatory T cells as a factor contributing ... See full document
120
Autoreactive T cells in type 1 diabetes
... Autoreactive T cells targeting a broad repertoire of antigens and epitopes are considered the main mediators of β cell death in ...products. T cells reacting with neoepitopes may have ... See full document
12
Direct modulation of myelin-autoreactive CD4<sup>+</sup> and CD8<sup>+</sup> T cells in EAE mice by a tolerogenic nanoparticle co-carrying myelin peptide-loaded major histocompatibility complexes, CD47 and multiple regulatory molecules
... β 1) to the target T cells by surface ligand presenta- tion and cytokine paracrine relsease, in the same spatial and temporal manner, and thus can directly modulate the T cells through ... See full document
20
Presented antigen from damaged pancreatic β cells activates autoreactive T cells in virus mediated autoimmune diabetes
... a type 1 IFN antivi- ral response without the accompanying damage of a viral infection ...memory T cells. Whether these activated T cells could then participate in an autoimmune ... See full document
10
Increased expression of regulatory T cell associated markers in recent onset diabetic children
... hi T cells are thought to be crucial for the maintenance of immunological tolerance to self ...these cells in the early stage of type 1 diabetes, as well as in a setting of ... See full document
8
Strong Ability of Nef-Specific CD4+ Cytotoxic T Cells To Suppress Human Immunodeficiency Virus Type 1 (HIV-1) Replication in HIV-1-Infected CD4+ T Cells and Macrophages
... dendritic cells, mac- rophages, and activated T cells, HIV-1-specific CD4 ⫹ CTLs may take the position left vacant due to escape from CD8 ⫹ CTL ...However, CD4 ⫹ CTLs can also ... See full document
10
Chen_unc_0153D_18140.pdf
... presenting cells (APCs) which then traffic to the draining LNs as previously observed ...particle type in the experiment, which might alter their migration away from the site of injection [67, ... See full document
252
CD4+ T Cells Are Required for the Priming of CD8+ T Cells following Infection with Herpes Simplex Virus Type 1
... virus type 1 (HSV-1) results in a wide spectrum of clinical presentations depending on the host’s age, the host’s immune status, and the route of inocu- lation ...⫹ T cells, play an ... See full document
13
CD4-Negative Cells Bind Human Immunodeficiency Virus Type 1 and Efficiently Transfer Virus to T Cells
... of infectious particles. In contrast, anti-LFA-1 antibody signif- icantly inhibited cell-bound virus infectivity but only marginally inhibited cell-free virus infection. Although other cell surface molecules could ... See full document
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