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[PDF] Top 20 Chimeric Nectin1-Poliovirus Receptor Molecules Identify a Nectin1 Region Functional in Herpes Simplex Virus Entry

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Chimeric Nectin1-Poliovirus Receptor Molecules Identify a Nectin1 Region Functional in Herpes Simplex Virus Entry

Chimeric Nectin1-Poliovirus Receptor Molecules Identify a Nectin1 Region Functional in Herpes Simplex Virus Entry

... of nectin1 responsible for entry of HSV-1 into susceptible cells and for the binding to ...mapping functional domains, provided the degree of homology of the two related proteins is sufficient to ... See full document

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The Domains of Glycoprotein D Required To Block Apoptosis Induced by Herpes Simplex Virus 1 Are Largely Distinct from Those Involved in Cell-Cell Fusion and Binding to Nectin1

The Domains of Glycoprotein D Required To Block Apoptosis Induced by Herpes Simplex Virus 1 Are Largely Distinct from Those Involved in Cell-Cell Fusion and Binding to Nectin1

... core region (residues 125, 126, and 151), one in the upstream connector region (residues 34 and 43), and one in the C-terminal portion of the ectodomain (residue ...connector region (residues 34 and ... See full document

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Cell-to-Cell Spread of Wild-Type Herpes Simplex Virus Type 1, but Not of Syncytial Strains, Is Mediated by the Immunoglobulin-Like Receptors That Mediate Virion Entry, Nectin1 (PRR1/HveC/HIgR) and Nectin2 (PRR2/HveB)

Cell-to-Cell Spread of Wild-Type Herpes Simplex Virus Type 1, but Not of Syncytial Strains, Is Mediated by the Immunoglobulin-Like Receptors That Mediate Virion Entry, Nectin1 (PRR1/HveC/HIgR) and Nectin2 (PRR2/HveB)

... soluble nectin1 (B) inhibit plaque formation in nectin1␣-expressing J cells infected with ...(A) Nectin1␣-expressing J cells in 96 wells, infected with R8102, were exposed to the indicated ... See full document

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Novel, Soluble Isoform of the Herpes Simplex Virus (HSV) Receptor Nectin1 (or PRR1-HIgR-HveC) Modulates Positively and Negatively Susceptibility to HSV Infection

Novel, Soluble Isoform of the Herpes Simplex Virus (HSV) Receptor Nectin1 (or PRR1-HIgR-HveC) Modulates Positively and Negatively Susceptibility to HSV Infection

... the poliovirus receptor (PVR/CD155) ...includes nectin1, also known as PRR1 (for poliovirus re- ceptor related), nectin2/PRR2, and the recently described nec- tin3/PRR3 (5, 7, 8, 13, ...human ... See full document

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Herpes Simplex Virus Glycoprotein D Can Bind to Poliovirus Receptor-Related Protein 1 or Herpesvirus Entry Mediator, Two Structurally Unrelated Mediators of Virus Entry

Herpes Simplex Virus Glycoprotein D Can Bind to Poliovirus Receptor-Related Protein 1 or Herpesvirus Entry Mediator, Two Structurally Unrelated Mediators of Virus Entry

... as herpes simplex virus (HSV) entry mediators ...factor receptor family, whereas the poliovirus recep- tor-related proteins 1 and 2 (PRR1 and PRR2, renamed HveC and HveB) belong ... See full document

11

Structural Features of Nectin-2 (HveB) Required for Herpes Simplex Virus Entry

Structural Features of Nectin-2 (HveB) Required for Herpes Simplex Virus Entry

... of herpes simplex virus (HSV) entry into cells is the binding of viral glycoprotein D (gD) to a cellular ...gD receptor for the entry of HSV-2, variant forms of HSV-1 that have ... See full document

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Substitution in the Murine Nectin1 Receptor of a Single Conserved Amino Acid at a Position Distal from the Herpes Simplex Virus gD Binding Site Confers High-Affinity Binding to gD

Substitution in the Murine Nectin1 Receptor of a Single Conserved Amino Acid at a Position Distal from the Herpes Simplex Virus gD Binding Site Confers High-Affinity Binding to gD

... murine nectin1 and, for the human nectin1, by immunoreac- tivity to CK35, a monoclonal antibody directed to the first C2-type domain of human nectin1 (17, ...murine nectin1. Similarly, cells ... See full document

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Functional Region IV of Glycoprotein D from Herpes Simplex Virus Modulates Glycoprotein Binding to the Herpesvirus Entry Mediator

Functional Region IV of Glycoprotein D from Herpes Simplex Virus Modulates Glycoprotein Binding to the Herpesvirus Entry Mediator

... to identify a HeLa cell gene product which, upon expression in normally nonpermis- sive Chinese hamster ovary (CHO) cells, allows for entry of many HSV strains ...herpesvirus entry mediator (HveA; ... See full document

8

Insertional Mutations in Herpes Simplex Virus Type 1 gL Identify Functional Domains for Association with gH and for Membrane Fusion

Insertional Mutations in Herpes Simplex Virus Type 1 gL Identify Functional Domains for Association with gH and for Membrane Fusion

... the entry of herpes simplex virus (HSV) into cells and for virus-induced cell ...to identify regions critical for gH binding and gH/gL processing and regions essential for cell ... See full document

9

The Ectodomain of a Novel Member of the Immunoglobulin Subfamily Related to the Poliovirus Receptor Has the Attributes of a Bona Fide Receptor for Herpes Simplex Virus Types 1 and 2 in Human Cells

The Ectodomain of a Novel Member of the Immunoglobulin Subfamily Related to the Poliovirus Receptor Has the Attributes of a Bona Fide Receptor for Herpes Simplex Virus Types 1 and 2 in Human Cells

... the functional cloning of a hitherto unknown member of the immunoglobulin (Ig) superfamily selected for its ability to confer susceptibility to herpes simplex virus (HSV) infection on a highly ... See full document

11

Localization on the herpes simplex virus type 1 genome of a region encoding proteins involved in adsorption to the cellular receptor.

Localization on the herpes simplex virus type 1 genome of a region encoding proteins involved in adsorption to the cellular receptor.

... MOORE,1 AND LARS HAARR`6 Department of Biochemistryl* and the Gade Institute, Departments of Pathology2 and Microbiology,6 University of Bergen, Bergen, Norway; Medical Research Council [r] ... See full document

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Entry of Herpes Simplex Virus 1 and Other Alphaherpesviruses via the Paired Immunoglobulin-Like Type 2 Receptor α

Entry of Herpes Simplex Virus 1 and Other Alphaherpesviruses via the Paired Immunoglobulin-Like Type 2 Receptor α

... Herpes simplex virus 1 (HSV-1) enters cells either via fusion of the virion envelope and host cell plasma membrane or via endocytosis, depending on the cell ...viral entry pathway dependent on ... See full document

8

Herpes Simplex Virus 1 Targets the Murine Olfactory Neuroepithelium for Host Entry

Herpes Simplex Virus 1 Targets the Murine Olfactory Neuroepithelium for Host Entry

... nasal entry unlikely, as human OB are rarely ...secondary virus spread, from meninges (48), bloodstream (39), or other brain regions, is more common than direct passage along olfactory ... See full document

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Susceptibility of Human Iris Stromal Cells to Herpes Simplex Virus 1 Entry

Susceptibility of Human Iris Stromal Cells to Herpes Simplex Virus 1 Entry

... HSV-1 entry receptors in HIS ...gD receptor nectin-1 was evident in HIS cells, while levels of HVEM and 3-OST-3 were found to be insignificant, suggesting that it is nectin-1 that is the gD receptor ... See full document

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Interaction of herpes simplex virus glycoprotein gC with mammalian cell surface molecules.

Interaction of herpes simplex virus glycoprotein gC with mammalian cell surface molecules.

... The entry of herpes simplex virus (HSV) into mammalian cells is a multistep process beginning with an attachment step involving glycoproteins gC and ...N-terminal region of gC is ... See full document

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Contributions of Herpes Simplex Virus 1 Envelope Proteins to Entry by Endocytosis

Contributions of Herpes Simplex Virus 1 Envelope Proteins to Entry by Endocytosis

... enhanced entry relative to that of the wild type for reasons that are not ...2B). Entry levels ranged from 5 times less than those of the wild type to 20 times ...⫺ virus entered CHO–nectin-1 cells 5 ... See full document

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The Virological Synapse Facilitates Herpes Simplex Virus Entry into T Cells

The Virological Synapse Facilitates Herpes Simplex Virus Entry into T Cells

... Despite the in vitro demonstration of numerous mechanisms by which viruses could affect the efficacy of the immune re- sponse, it has proven difficult to demonstrate that these mech- anisms are operative in vivo. For ... See full document

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Adenovirus vector expressing functional herpes simplex virus ICP0.

Adenovirus vector expressing functional herpes simplex virus ICP0.

... Infection of HeLa cells or 293 cells a human embryo kidney cell line expressing adenovirus 5 Ela and -b functions with the MLP-0 recombinant results in the synthesis of more IE-0 mRNA an[r] ... See full document

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Unstable heterozygosity in a diploid region of herpes simplex virus DNA.

Unstable heterozygosity in a diploid region of herpes simplex virus DNA.

... The presence of the doublet All joint-spanning fragments of this stock was consistent with two possibilities: either the plaque purification had not resulted in clonal populations of vir[r] ... See full document

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Cellular Proteasome Activity Facilitates Herpes Simplex Virus Entry at a Postpenetration Step

Cellular Proteasome Activity Facilitates Herpes Simplex Virus Entry at a Postpenetration Step

... HSV entry by either endocytic or nonendocytic routes are rapid (12, 31, 54, ...the entry pathway taken, incoming capsids dock at the nuclear envelope in ⬍ 1 h (2, 48, 54, ...to identify the viral ... See full document

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