[PDF] Top 20 Cleavage of a viral polyprotein by a cellular proteolytic activity.
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Cleavage of a viral polyprotein by a cellular proteolytic activity.
... The 200K polyprotein was synthesized in the reticulocyte lysate in the absence of DTT, and then the reaction mixtures were serially diluted either with a blank lysate translation solutio[r] ... See full document
5
Macromolecular Assembly-Driven Processing of the 2/3 Cleavage Site in the Alphavirus Replicase Polyprotein
... of viral polyprotein processing is attempted to be explained by apparent differences in the cleavage efficiencies of short peptides representing cleavage ...of viral rep- licase can be ... See full document
13
Mutagenesis of the yellow fever virus NS2B/3 cleavage site: determinants of cleavage site specificity and effects on polyprotein processing and viral replication.
... for cleavage at certain ...for cleavage site specificity (16), the relative importance of amino acid residues within the con- sensus cleavage site as determinants of cleavage efficiency has ... See full document
6
Cleavage of the dengue virus polyprotein at the NS3/NS4A and NS4B/NS5 junctions is mediated by viral protease NS2B-NS3, whereas NS4A/NS4B may be processed by a cellular protease.
... 3 0022-538X/92/031535-08$02.00/0 Copyright C 1992, American Society for Microbiology Cleavage of the Dengue Virus Polyprotein at the NS3/NS4A and NS4B/NS5 Junctions Is Mediated by Viral [r] ... See full document
8
Proteolytic cleavage analysis at the Murray Valley encephalitis virus NS1 2A junction
... NS1-NS2A polyprotein region, also did not markedly impinge on RNA and virus replication in cell culture, regardless of amino acid ...NS1-NS2A cleavage site is in substrate recognition by the protease, which ... See full document
11
Proteolytic Processing of a Serotype 8 Human Astrovirus ORF2 Polyprotein
... The cleavage of VP90 to yield VP70 seems to be cell-associated since the protein samples used in this analysis were harvested after removing the culture medium; however, it does not represent a cleavage ... See full document
7
Improving Proteolytic Cleavage at the 3A/3B Site of the Hepatitis A Virus Polyprotein Impairs Processing and Particle Formation, and the Impairment Can Be Complemented intrans by 3AB and 3ABC
... of cleavage site mutations on hepatitis A virus (HAV) polyprotein processing, particle formation, and ...retarded cleavage at the 3A/3B junction can be improved by altering the amino acid sequence at ... See full document
12
Ty1 Proteolytic Cleavage Sites Are Required for Transposition: All Sites Are Not Created Equal
... a viral multienzyme complex that initiates an ordered sequence of events leading to virus assembly and ...propagation. Viral peptides are initially synthesized as polyprotein pre- cursors; these ... See full document
7
Proteolytic Cleavage of Bovine Adenovirus 3-Encoded pVIII
... by proteolytic cleavage of three minor capsid proteins, three core proteins, and one nonstructural protein (8, ...cofactors, viral DNA and a C-terminal 11-amino-acid peptide of adenovirus protein ... See full document
18
3C-like protease of rabbit hemorrhagic disease virus: identification of cleavage sites in the ORF1 polyprotein and analysis of cleavage specificity.
... the cleavage site at the N terminus of the ...exhibits proteolytic activity upon expression in ...ORF1 polyprotein at a site that has been tentatively mapped to the N-terminal boundary of the ... See full document
10
A New Role for ns Polyprotein Cleavage in Sindbis Virus Replication
... the viral replication complex (RC), which func- tions in both RNA genome replication and the synthesis of the subgenomic (SG) ...the viral structural proteins that, together with the genome RNA, form ... See full document
14
Exchange of the Coronavirus Replicase Polyprotein Cleavage Sites Alters Protease Specificity and Processing
... of cleavage site replacement vi- ...ORF1ab polyprotein is shown with nonstruc- tural proteins (nsp1 to -16) indicated by vertical lines and ...numbers. Viral papain-like protease domains in nsp3 are ... See full document
5
Inhibition of Poliovirus-Induced Cleavage of Cellular Protein PCBP2 Reduces the Levels of Viral RNA Replication
... noncanonical cellular translation factors aid in ribosome recruitment and translation initiation to translate the picornavirus genome into a single poly- protein that is subsequently processed to produce mature ... See full document
10
Phosphorylation and Proteolytic Cleavage of Gag Proteins in Budded Simian Immunodeficiency Virus
... of cellular protein kinase A (C-PKA) (8), active extracellular signal-regulated kinase 2 (ERK-2) (7, 28), and a 53-kDa serine/ threonine kinase that remains to be identified ...kinase activity appears to be ... See full document
9
Proteolytic single hinge cleavage of pertuzumab impairs its Fc effector function and antitumor activity in vitro and in vivo
... ADCC activity of scIgG-P as ...protease-expressing cellular set- tings, PRIgG-T conferred resistance to proteolytic hinge cleavage both in vitro and in vivo ... See full document
12
Bovine viral diarrhea virus NS3 serine proteinase: polyprotein cleavage sites, cofactor requirements, and molecular model of an enzyme essential for pestivirus replication.
... for cleavage at both the 4B/5A and the 5A/5B ...for cleavage at the 4B/5A site, but unlike in BVDV, processing at the HCV 5A/5B site occurs with reasonable efficiency in the absence of the cofactor (see ... See full document
11
Proteolytic processing in African swine fever virus: evidence for a new structural polyprotein, pp62.
... To ascertain that protein p35 was produced after the cleav- age of one of the two overlapping Gly-Gly-X sequences at positions 157 to 160 (Fig. 1B), we analyzed the amino-terminal sequence of structural protein p35 ... See full document
6
Proteolytic processing of the coronavirus infectious bronchitis virus 1a polyprotein: identification of a 10-kilodalton polypeptide and determination of its cleavage sites.
... the polyprotein encoded by mRNA 1 is an essential step in coronavirus RNA replication and gene ...1a/1b polyprotein, leading to the formation of a mature viral protein of 100 ...1a polyprotein ... See full document
7
Proteolytic activity of human cytomegalovirus UL80 protease cleavage site mutants.
... In HSV, SCMV, and HCMV, release cleavage of the N-terminal region of the protease polyprotein to yield an active protease 30-kDa in HCMV is conserved and may be important for efficient m[r] ... See full document
11
Cleavage Map and Proteolytic Processing of the Murine Norovirus Nonstructural Polyprotein in Infected Cells
... The Nterm protein, together with the next two proteins (NTPase and p18) in the gene order of the MNV ORF1, may be involved the formation of the virus replication complex (14, 19, 50). Despite the presence of significant ... See full document
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