[PDF] Top 20 Combining effects from rare and common genetic variants in an exome wide association study of sequence data
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Combining effects from rare and common genetic variants in an exome wide association study of sequence data
... this study we considered the first 100 replicates of quantitative phenotype Q1 in 697 unrelated individuals in the Genetic Analysis Workshop 17 (GAW17) data set ...only rare variants ... See full document
6
Comparative study of statistical methods for detecting association with rare variants in exome resequencing data
... genome-wide association studies have successfully detected many common genetic variants that are associated with complex ...or rare variants are also contributing to ... See full document
7
Two stage study designs combining genome wide association studies, tag single nucleotide polymorphisms, and exome sequencing: accuracy of genetic effect estimates
... Genome-wide association studies (GWAS) test for disease-trait associations and estimate effect sizes at tag single- nucleotide polymorphisms (SNPs), which imperfectly capture variation at causal ...or ... See full document
7
Case control association testing by graphical modeling for the Genetic Analysis Workshop 17 mini exome sequence data
... this data set, our method detected five causal variants on four ...three variants associated with disease status: C1S9445 in PIK3C2B , C6S2981 in VEGFA , and C10S3050 in SIRT1 ...these ... See full document
5
Enrichment analysis of genetic association in genes and pathways by aggregating signals from both rare and common variants
... for combining association signals across multiple ...small effects of rare variants, with two methods for gene set enrichment analysis and demonstrated the importance of normalizing ... See full document
5
Exome-Wide Association Study of the ACCORD Clinical Trial.
... whole-exome study of the ACCORD data, there are a limited number of current GWAS studies with which to replicate any ...confounding from coadministration of drugs. A more straightforward ... See full document
123
Gene based analysis of rare and common variants to determine association with blood pressure
... funding from the Natural Sciences and Engineering Research Council of Canada (NSERC) (grant number 293295-2009) and Canadian Institutes of Health Research (CIHR) (grant number ...the Genetic Determinants of ... See full document
5
Pathway based joint effects analysis of rare genetic variants using Genetic Analysis Workshop 17 exon sequence data
... genome-wide association studies have been widely used to identify genetic risk factors for complex ...many genetic studies. For example, so far, many variants have been discovered that ... See full document
5
Patient complexity and genotype-phenotype correlations in biliary atresia: a cross-sectional analysis
... The study is a cross-sectional observational study collating with case/control association ...control association tests, including 89 patients ...genes from the genome-wide ... See full document
9
Pathway based analysis of rare and common variants to test for association with blood pressure
... funding from the Natural Sciences and Engineering Research Council of Canada (NSERC) (grant number 293295-2009) and Canadian Institutes of Health Research (CIHR) (grant number ...the Genetic Determinants of ... See full document
5
A pathway based association analysis model using common and rare variants
... causal variants, an abundance of research has been focused on relatively frequent variants that are assumed to be located near the true causal var- ...that common single-nucleotide polymorphisms ... See full document
5
A general method for combining different family based rare variant tests of association to improve power and robustness of a wide range of genetic architectures
... Few current methods allow for a flexible combination of family-based rare-variant tests of association. In re- sponse, we propose an adaptable framework for combin- ing any number and type of gene-based ... See full document
6
Association of genetic loci for migraine susceptibility in the she people of China
... Categorical variables were presented as numbers and per- centages, and continuous variables were shown as mean and standard deviation. T-test was used to compare age dif- ference between migraine and control groups. ... See full document
6
Evaluation of the association of C5 with neovascular age-related macular degeneration and polypoidal choroidal vasculopathy
... resulting from the interactions of aging, genetic and environmental ...molecular genetic studies, including candidate gene analysis, genome-wide association studies (GWAS), and ... See full document
7
Powerful Genetic Association Analysis for Common or Rare Variants with High-Dimensional Structured Traits
... Many genetic association studies collect a wide range of complex ...a common genetic mechanism, joint analysis can be statistically more powerful and biologically more ...kernel-based ... See full document
12
A rare functional variant of SHARPIN attenuates the inflammatory response and associates with increased risk of late-onset Alzheimer’s disease
... a rare nonsynonymous variant (rs75932628: ...its association with LOAD were indicated by using a mouse model of ...TREM2, rare coding variants have been reported in PLCG2 and ...these ... See full document
9
Exploration and comparison of methods for combining population and family based genetic association using the Genetic Analysis Workshop 17 mini exome
... a rare disease and no population stratification are necessary for ...of combining the RR estimates is not well powered, as evi- denced by our simulations, which often did not confer sufficient evidence to ... See full document
6
Genetic Variant Selection: Learning Across Traits and Sites
... the common practice of using a truncated Gaussian works ...candidate variants the one for which to propose a change of ...changed from one to zero, the asso- ciated entries of Z also have to be ... See full document
39
<p>The association between CD157/BST1 polymorphisms and the susceptibility of Parkinson’s disease: a meta-analysis</p>
... the study conducted by Satake et al 20 involved two different ...the association between rs11931532, rs4698412, and rs11724635 and PD risk, ...The genetic distributions of the control groups in all ... See full document
14
Genetic mechanisms and age-related macular degeneration: common variants, rare variants, copy number variations, epigenetics, and mitochondrial genetics
... a common locus in linkage disequilibrium on the long arm of chromosome ...protective effects could not be attributed to the CFH Y402H genotype ...its effects are also independent of the ... See full document
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