[PDF] Top 20 Construction of Protein Protein Interaction Network Using Community Molecular Detection
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Construction of Protein Protein Interaction Network Using Community Molecular Detection
... The detection of protein complexes[4] using PPI networks can help in understanding the mechanisms regulating cell ...detecting protein complexes using PPI networks can be ... See full document
12
Construction and Analysis of Tissue-Specific Protein-Protein Interaction Networks in Humans
... In this paper, we studied the human proteins in different tissues of the body. We were looking to see how functions may change from one tissue to the other. In this study, it has been shown that some proteins are not ... See full document
13
Construction and analysis of protein-protein interaction network associated with human sperm-egg interaction
... identify protein-protein interaction between human sperm and egg (Evans, ...of protein complexes, many efforts have failed to comprehensively elucidate the fusion mechanism and the ... See full document
44
Fitting a geometric graph to a protein-protein interaction network
... In this section, we outline the main ideas behind the algorithm and show how we propose to evaluate its accuracy. Our task is to embed proteins into R 2 , R 3 or R 4 given the PPI network. Rather than Euclidean ... See full document
7
Using Protein-Protein Interaction Network to Prioritize Drug Targets for Malaria
... obtained using STRING. This was followed by the construction of a protein protein interaction network of ...this network revealed important proteins that are essential for ... See full document
11
Using Protein-Protein Interaction Network to Prioritize Drug Targets for Malaria
... obtained using STRING. This was followed by the construction of a protein protein interaction network of ...this network revealed important proteins that are essential for ... See full document
11
Identification of key pathways and genes with aberrant methylation in prostate cancer using bioinformatics analysis
... from protein–protein interaction network construction using Search Tool for the Retrieval of Inter- acting Genes contributed to hormonal response, inflammatory response, cell ... See full document
9
A novel functional module detection algorithm for protein-protein interaction networks
... clustering using conventional ...[7], Molecular Complex Detec- tion (MCODE) [12], Spirin and Mirny [11] algorithms identify densely connected subgraphs rather than fully connected ones by either optimizing ... See full document
11
Protein complex detection with semi-supervised learning in protein interaction networks
... However, protein complexes are likely to overlap and the interaction data are very ...meaningful protein complex ...assume protein complexes should be dense sub- ...it. Molecular ... See full document
9
Construction and analysis of a comprehensive protein interaction network of HCV with its host Homo sapiens
... of protein-protein interaction ...PPI detection have many limitations such as high false positive rate, high cost, time-consuming, and ...the interaction data gener- ated by ... See full document
9
Original Article Data-independent acquisition strategy for the serum proteomics of tuberculosis
... the protein expression profiles in respi- ratory compartments of ferrets infected with influenza viruses, and the integrative bioinfor- matics analysis of the data uncovered relation- ships between host responses ... See full document
14
RETRACTED ARTICLE: Establishing an osteosarcoma associated protein-protein interaction network to explore the pathogenesis of osteosarcoma
... Methods: The gene expression profile GSE9508 was downloaded from the Gene Expression Omnibus database, including five samples of non-malignant bone (the control), seven samples for non-metastatic patients (six of which ... See full document
7
Protein–protein interaction in insulin signaling and the molecular mechanisms of insulin resistance
... SH2 adaptor proteins recognize and bind to tyrosine- phosphorylated proteins by their SH2 domains. They do not possess intrinsic enzymatic activity but relay the lig- and signal by additional ... See full document
14
Original Article Proteomics and bioinformatics analysis of mouse hypothalamic neurogenesis with or without EPHX2 gene deletion
... found to antagonize inflammation via negative regulation of nuclear factor-κB (NF-κB) [5]. Given the salutary effects of sEH deficiency, it global expression of proteins in tissues and flu- ids [11]. The proteins or ... See full document
12
PROTEIN INTERACTION NETWORK AND DRUG DISCOVERY
... with protein Interleukine-6 displays, stable interaction at the interacting sites of one of the standard drug molecules as ...by interaction among the protein residues in complex, indicate ... See full document
9
A Meta-Heuristic Approach to Predict Protein-Protein Interaction Network
... The receiver operating curves (ROCs) for different PPI prediction algorithms for interactions obtained from BioGrid database is plotted in Fig. 5(a). ROCs are a useful technique for examining the efficacy of a prediction ... See full document
10
Open source tool for prediction of genome wide protein-protein interaction network based on ortholog information
... diseases. Interaction networks (interactomes) for many model organisms have been established experi- ...of protein-protein inter- actions requires labor-intensive techniques, such as ... See full document
6
Identification of the targets of hematoporphyrin derivative in lung adenocarcinoma using integrated network analysis
... untreated; the X-ray group was treated with 10 Gy X-ray and cultured for 24 h; X-ray + HPD group was treated with 10 Gy X-ray + 10 μg/mL of HPD and cul- tured for 24 h; each group had three replicates), the cells were ... See full document
15
Pathway annotation and analysis with Reactome: The solute carrier class of membrane transporters
... A new feature of Reactome is the pathway diagram (Figure 1). Here, reactions in a pathway are rep- resented as connected, interactive objects. Each reaction displays the entities ( proteins or other mol- ecules) that ... See full document
6
Protein interaction sentence detection using multiple semantic kernels
... performed using a version of Student ’ s t-test designed for 10 × 10 cross-validation ...[7]. Protein names are substituted by placeholder strings PTNGNE concatenated to the number of the protein ... See full document
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