[PDF] Top 20 Control of Human Immunodeficiency Virus Type 1 Is Associated with HLA-B*13 and Targeting of Multiple Gag-Specific CD8+ T-Cell Epitopes
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Control of Human Immunodeficiency Virus Type 1 Is Associated with HLA-B*13 and Targeting of Multiple Gag-Specific CD8+ T-Cell Epitopes
... that Gag-specific CD8 ⫹ T- cell responses may be critical in the immune control of HIV (10, 21, 22, 32, 35, ...that HLA- B*13 is associated with lower ... See full document
6
Escape from the Dominant HLA-B27-Restricted Cytotoxic T-Lymphocyte Response in Gag Is Associated with a Dramatic Reduction in Human Immunodeficiency Virus Type 1 Replication
... targeted epitopes to evade recognition (41, 64). Mutational escape from CD8 ⫹ T-cell responses is well defined in many viral infections (3, 70), and studies of both HIV-1 and SIV ... See full document
12
Human Immunodeficiency Virus Type 1 (HIV-1)-Specific CD8+-T-Cell Responses for Groups of HIV-1-Infected Individuals with Different HLA-B*35 Genotypes
... the B*35 subgroups. Individuals with one copy of HLA-B*35-Px progress to AIDS significantly faster than those who are homozygous for other alleles at the HLA-B locus (8), suggesting ... See full document
8
Broad Cross-Clade T-Cell Responses to Gag in Individuals Infected with Human Immunodeficiency Virus Type 1 Non-B Clades (A to G): Importance of HLA Anchor Residue Conservation
... determining CD8 ⫹ T-cell responses, it does not nec- essarily provide a clear correlate of ...of T-cell responses and clinical parame- ters, such as viral load and CD4 ⫹ ...HIV- ... See full document
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Evidence of CD8+ T-Cell-Mediated Selective Pressure on Human Immunodeficiency Virus Type 1 nef in HLA-B*57+ Elite Suppressors
... ⫹ T cells (30). It is not known how ES continue to control viral replication in light of these escape ...temporally associated with a loss of control of viral replication (5, 6, 14, ...the ... See full document
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HLA-B63 Presents HLA-B57/B58-Restricted Cytotoxic T-Lymphocyte Epitopes and Is Associated with Low Human Immunodeficiency Virus Load
... of HLA class I alleles have been associated with slow HIV disease progression, but the relative contribution of the presenting allele versus the restricted epitopes towards this relative protection ... See full document
8
Comprehensive Screening for Human Immunodeficiency Virus Type 1 Subtype-Specific CD8 Cytotoxic T Lymphocytes and Definition of Degenerate Epitopes Restricted by HLA-A0207 and -CW0304 Alleles
... of human immunodeficiency virus type 1 (HIV-1)-derived broadly cross-subtype-reactive CD8 cytotoxic T lymphocyte (CTL) epitopes were ...expressing ... See full document
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Identification of Novel HLA-A2-Restricted Human Immunodeficiency Virus Type 1-Specific Cytotoxic T-Lymphocyte Epitopes Predicted by the HLA-A2 Supertype Peptide-Binding Motif
... HIV-1-negative control subjects. All 41 individuals studied expressed the HLA-A2 allele, and of the 21 HIV-1-infected individuals who were subtyped for HLA-A2, 19 (91%) expressed ... See full document
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Multifunctional Human Immunodeficiency Virus (HIV) Gag-Specific CD8+ T-Cell Responses in Rectal Mucosa and Peripheral Blood Mononuclear Cells during Chronic HIV Type 1 Infection
... HIV-specific CD8 ⴙ T cells are found in both the rectum and peripheral ...HIV-1-specific T-cell response patterns in both mucosal MNC and ...HIV Gag stimulation are ... See full document
12
Antiviral Activity of Human Immunodeficiency Virus Type 1 Gag-Specific Cytotoxic T Lymphocyte Targeting Is Not Necessarily Intrinsically Superior to Envelope Targeting
... the Gag-specific CD8 ⫹ T lymphocyte (CTL) re- sponse and viremia and often a positive correlation of viremia with the Env-specific CTL ...epitope targeting of human ... See full document
5
Overlapping epitopes in human immunodeficiency virus type 1 gp120 presented by HLA A, B, and C molecules: effects of viral variation on cytotoxic T-lymphocyte recognition.
... CD8 1 CTL recognize target cells through the binding of their T-cell receptor (TCR) to 8- to 11-amino-acid (aa) anti- genic peptides complexed with major histocompatibility com- plex (MHC) ... See full document
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Frequent and Variable Cytotoxic-T-Lymphocyte Escape-Associated Fitness Costs in the Human Immunodeficiency Virus Type 1 Subtype B Gag Proteins
... distinct HLA class I association in which the escape mutation (T81, E260, or E312) reflects the high-frequency HIV-1B consen- sus amino acid residue and the susceptible, or targetable, amino acid (A81, D260, or ... See full document
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CD8 T-Cell Recognition of Multiple Epitopes within Specific Gag Regions Is Associated with Maintenance of a Low Steady-State Viremia in Human Immunodeficiency Virus Type 1-Seropositive Patients
... ineffective, CD8 T-cell response during chronic HIV infection is the tar- geting of the Gag epitope ...viral control during the chronic phase of ...targeted epitopes during the ... See full document
9
Functional Consequences of Human Immunodeficiency Virus Escape from an HLA-B*13-Restricted CD8+ T-Cell Epitope in p1 Gag Protein
... C virus-infected B*13 individuals, while only 11% carry either I437M or ...the HLA-B*13-re- stricted RI9 response, as well as the extent of non-CTL anti- HIV immune activity, and ... See full document
8
Multiple T-Cell Responses to Human Immunodeficiency Virus Type 1 Are Enhanced by Dendritic Cells
... tional CD8 ⫹ T-cell reactivity to single HIV-1 peptides repre- senting the minimal, optimal HLA A*0201 epitope SL9, as well as to 15-mer and 20-mer extensions of this ...These ... See full document
14
HLA Class I Binding Promiscuity of the CD8 T-Cell Epitopes of Human Papillomavirus Type 16 E6 Protein
... vaccinia virus expressing modified HPV 16/18 E6 and E7 proteins ...in 1 of 3 (33%) evaluable patients with advanced cervical cancer, 3 of 12 (25%) cervical intraepithelial neoplasia 3 (CIN 3) subjects, and ... See full document
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Ontogeny and Specificities of Mucosal and Blood Human Immunodeficiency Virus Type 1-Specific CD8+ Cytotoxic T Lymphocytes
... to 1 ng of peptide per ml ...target cell lysis of 75 to 80% with 100 ng of Gag peptide (aa 147 to 155) per ml and the minimal antigen concentration associated with effective cytolysis was ... See full document
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Trafficking of Human Immunodeficiency Virus Type 1-Specific CD8+ T Cells to Gut-Associated Lymphoid Tissue during Chronic Infection
... addressin cell adhesion molecule-1 [MadCAM-1]), and ␣E7, whose ligand is E-cadherin on intestinal epithelial cells, are critical for lym- phocyte homing to GALT (1, 7, ...primed T ... See full document
11
Why Are CD8 T Cell Epitopes of Human Influenza A Virus Conserved?
... why CD8 T cell epitopes of human IAV are ...universal T cell-inducing vaccines against influenza and whether the virus is likely to evolve to escape the ... See full document
13
A molecular switch in immunodominant HIV 1 specific CD8 T cell epitopes shapes differential HLA restricted escape
... the HLA type, we speculate that HLA-B*07:02 expressing individuals may select a TCR, sensitive to the R71K mutation, that is not selected in HLA-B*42:01/42:02/81:01 positive ... See full document
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