Top PDF Long-Term Control of Simian Immunodeficiency Virus (SIV) in Cynomolgus Macaques Not Associated with Efficient SIV-Specific CD8+ T-Cell Responses
Long-Term Control of Simian Immunodeficiency Virus (SIV) in Cynomolgus Macaques Not Associated with Efficient SIV-Specific CD8+ T-Cell Responses
... viral control in 6 CyM intrarectally infected with low doses (5 50% animal infectious doses [AID 50 ]) of SIVmac 251 ...a long-term-controller ...usually associated with this phenotype, and ...
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Specific CD8+ T Cell Responses Correlate with Control of Simian Immunodeficiency Virus Replication in Mauritian Cynomolgus Macaques
... cious CD8 ⫹ T cell ...of virus-derived epitopes than do homozygous ones, allowing a larger number of distinct CD8 ⫹ T cell specificities to target infected ...broader ...
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Expansion of Simian Immunodeficiency Virus (SIV)-Specific CD8 T Cell Lines from SIV-Naive Mauritian Cynomolgus Macaques for Adoptive Transfer
... ABSTRACT CD8 T cells play a crucial role in the control of human immunodeficiency virus (HIV) and simian immunodeficiency virus ...the specific qualities and ...
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Recombinant Yellow Fever Vaccine Virus 17D Expressing Simian Immunodeficiency Virus SIVmac239 Gag Induces SIV-Specific CD8+ T-Cell Responses in Rhesus Macaques
... more efficient after a prime with DNA or recombinant BCG (rBCG) (4, 11, 15, ...two macaques that had been primed with rBCG expressing SIV proteins ...
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Dynamics of T-Cell Responses and Memory T Cells during Primary Simian Immunodeficiency Virus Infection in Cynomolgus Macaques
... immune responses appeared to be similar to the kinetics of memory CD8 ⫹ T ...highest SIV-specific proliferative IFN- ␥ and IL-2 responses were during primary infection coinciding ...
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Pathogenicity of Simian-Human Immunodeficiency Virus SHIV-89.6P and SIVmac Is Attenuated in Cynomolgus Macaques and Associated with Early T-Lymphocyte Responses
... with SIV develop plasma virus levels and an attenuated disease course that approximates those seen in HIV infection ...plasma virus level or changes in CD4 ⫹ T-cell number, that have ...
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Impairment of Gag-Specific CD8+ T-Cell Function in Mucosal and Systemic Compartments of Simian Immunodeficiency Virus mac251- and Simian-Human Immunodeficiency Virus KU2-Infected Macaques
... several simian immunodeficiency virus mac251 (SIV mac251 ) cytotoxic T-lymphocyte epitopes recognized by CD8 ⴙ T cells of infected rhesus macaques carrying the ...
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Occult Systemic Infection and Persistent Simian Immunodeficiency Virus (SIV)-Specific CD4+-T-Cell Proliferative Responses in Rhesus Macaques That Were Transiently Viremic after Intravaginal Inoculation of SIV
... female macaques that had been inoculated intravaginally with pathogenic SIVmac251 became transiently ...after SIV inoculation became persistently viremic and developed simian ...weak ...
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Multi-Low-Dose Mucosal Simian Immunodeficiency Virus SIVmac239 Challenge of Cynomolgus Macaques Immunized with “Hyperattenuated” SIV Constructs
... memory T-cell responses (26, 39) highlight the complex interplay required and suggest that the characteristics of a priming dose are of absolute importance and relate to factors other than magnitude ...
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FoxP3+ CD25+ CD8+ T-Cell Induction during Primary Simian Immunodeficiency Virus Infection in Cynomolgus Macaques Correlates with Low CD4+ T-Cell Activation and High Viral Load
... human immunodeficiency virus (HIV) infection but may influence viremia during primary infection, thereby possibly affecting long-term disease ...regulatory T cells may contribute to ...
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Mauritian Cynomolgus Macaques Share Two Exceptionally Common Major Histocompatibility Complex Class I Alleles That Restrict Simian Immunodeficiency Virus-Specific CD8+ T Cells
... of SIV-infected MCM expressing neither Mafa- A*25 nor Mafa-A*29 becomes ...elite control of SIV, but large cohorts of genetically diverse SIV-infected animals were required for these ...the ...
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Macaque Long-Term Nonprogressors Resist Superinfection with Multiple CD8+ T Cell Escape Variants of Simian Immunodeficiency Virus
... successful control of HIV have yet to yield conclusive ...the control of HIV replication associated with HLA-B27 (19, 20, ...novo responses to epitope vari- ants (3) and can maintain ...
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Involvement of Multiple Epitope-Specific Cytotoxic T-Lymphocyte Responses in Vaccine-Based Control of Simian Immunodeficiency Virus Replication in Rhesus Macaques
... rhesus macaques with a DNA prime/modified vaccinia virus Ankara boost regimen induces broad simian immunodeficiency virus (SIV)-specific T-cell ...
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Control of Simian Immunodeficiency Virus Replication by Vaccine-Induced Gag- and Vif-Specific CD8+ T Cells
... effective T cell-based AIDS vaccine, it is critical to define the antigens that elicit the most potent re- ...Vif/Nef-specific CD8 ⴙ T cells can be important in control of the ...
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Simian Immunodeficiency Virus (SIV) Infection Influences the Level and Function of Regulatory T Cells in SIV-Infected Rhesus Macaques but Not SIV-Infected Sooty Mangabeys
... of SIV/HIV infection. A recent study suggests that cytotoxic-T-lymphocyte-associated antigen 4 blockade on Tregs in conjunction with ART further reduces vRNA expres- sion in tissues and that this was ...
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Impact of Cytotoxic-T-Lymphocyte Memory Induction without Virus-Specific CD4+ T-Cell Help on Control of a Simian Immunodeficiency Virus Challenge in Rhesus Macaques
... unvaccinated macaques showed lower viral ...rhesus macaques (reference 15 and unpublished data), all unvaccinated 90-120-Ia-negative animals failed to contain a SIVmac239 challenge and animals, including ...
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With Minimal Systemic T-Cell Expansion, CD8+ T Cells Mediate Protection of Rhesus Macaques Immunized with Attenuated Simian-Human Immunodeficiency Virus SHIV89.6 from Vaginal Challenge with Simian Immunodeficiency Virus
... effector T cells in the vaginal mucosa of female rhesus macaques immunized with live-attenuated simian-human immunodeficiency virus ...pathogenic simian immunodeficiency ...
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Detection of simian immunodeficiency virus (SIV)-specific CD8+ T cells in macaques protected from SIV challenge by prior SIV subunit vaccination.
... to simian immunodeficiency virus (SIV), we studied three macaques that had been immunized with a recombinant vaccinia virus-based SIV subunit vaccine regimen and exhibited ...
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Simian Immunodeficiency Virus (SIV)-Specific CD8+ T-Cell Responses in Vervet African Green Monkeys Chronically Infected with SIVagm
... DISCUSSION CD8 ⫹ T-cell responses play a major role in partial viral containment of pathogenic AIDS virus infections in humans ...in SIV Gag and Env peptide-stimulated ...
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Inhibition of Simian Immunodeficiency Virus (SIV) Replication by CD8+ T Lymphocytes from Macaques Immunized with Live Attenuated SIV
... of SIV replication by CD8 1 T lymphocytes from macaques immunized with SIVmac239Dnef or ...from macaques infected with either wild-type SIV or live attenuated SIV and from ...
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