[PDF] Top 20 Coreceptor usage of primary human immunodeficiency virus type 1 isolates varies according to biological phenotype.
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Coreceptor usage of primary human immunodeficiency virus type 1 isolates varies according to biological phenotype.
... The biological phenotype of primary human immunodeficiency virus type 1 (HIV-1) isolates varies according to the severity of the HIV ... See full document
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Primary Human Immunodeficiency Virus Type 2 (HIV-2) Isolates, Like HIV-1 Isolates, Frequently Use CCR5 but Show Promiscuity in Coreceptor Usage
... Coreceptor usage of primary human immunodeficiency virus type 1 (HIV-1) isolates varies according to biological ...CXCR4 ... See full document
7
Heterogeneous Spectrum of Coreceptor Usage among Variants within a Dualtropic Human Immunodeficiency Virus Type 1 Primary-Isolate Quasispecies
... and coreceptor choice (17, ...of coreceptor use in ...or coreceptor use suggests that for this strain the dual phenotype is “dominant” and that members of this swarm may be rather plastic in ... See full document
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Use of Inhibitors To Evaluate Coreceptor Usage by Simian and Simian/Human Immunodeficiency Viruses and Human Immunodeficiency Virus Type 2 in Primary Cells
... tropic virus in PBMC was inhibited only by very high concentrations of AMD3100 and was com- pletely insensitive to SDF-1␣, TAK-779, or ...tive coreceptor to enter human PBMC, perhaps the CXCR5 ... See full document
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No Selection for CCR5 Coreceptor Usage during Parenteral Transmission of Macrophagetropic Syncytium-Inducing Human Immunodeficiency Virus Type 1
... Human immunodeficiency virus type 1 (HIV-1) isolates can display differences in biological properties, such as replication rate, syncytium-inducing (SI) capacity, ... See full document
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Patterns of CCR5, CXCR4, and CCR3 Usage by Envelope Glycoproteins from Human Immunodeficiency Virus Type 1 Primary Isolates
... between coreceptor usage profiles and fusion specificities for natural target cells: evidence for functional CXCR4 on ...the primary isolates to mediate fusion with natural hu- man target cell ... See full document
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The Promiscuous CC Chemokine Receptor D6 Is a Functional Coreceptor for Primary Isolates of Human Immunodeficiency Virus Type 1 (HIV-1) and HIV-2 on Astrocytes
... on primary astrocytes, and siRNAs against D6 mRNA inhibited the infection of these cells by many of the same ...D6 usage by HIV-1 and -2 may be important for brain patho- ...other primary cell ... See full document
7
N-Linked Glycosylation of CXCR4 Masks Coreceptor Function for CCR5-Dependent Human Immunodeficiency Virus Type 1 Isolates
... functional coreceptor for otherwise-restricted R5 isolate ...principal coreceptor, CCR5, does not appear to possess any N-linked glycosylation modifications, although there is a potential site in the ... See full document
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Biological Signature Characteristics of Primary Isolates from Human Immunodeficiency Virus Type 1 Group O in Ex Vivo Human Tonsil Histocultures
... R5 isolates FIG. 5. Cross-donor and HIV-1 group-stratified analyses of HIV-1 ...on primary cells from multiple donors as described in the legend to ...each virus (A) in a combined ... See full document
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Determination of Coreceptor Usage of Human Immunodeficiency Virus Type 1 from Patient Plasma Samples by Using a Recombinant Phenotypic Assay
... syncytium-inducing phenotype of the over- all isolate reflected CXCR4 usage by dualtropic clones ...the virus populations analyzed here by TRT were a mixture of R5-specific and dualtropic viruses ... See full document
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Evidence that Antibody-Mediated Neutralization of Human Immunodeficiency Virus Type 1 by Sera from Infected Individuals Is Independent of Coreceptor Usage
... of virus neutralization by sera from infected individuals, coreceptor usage probably does not de- termine the ability of HIV-1 to be neutralized by ...used human monoclonal antibodies ... See full document
8
Macrophage tropism of human immunodeficiency virus type 1 and utilization of the CC-CKR5 coreceptor.
... fected primary PBMC and ...Env-pseudotyped virus and lowest for the clade F ...ceptor usage of these reporter viruses was then investigated by infection of stable CD4 1 human ... See full document
5
Preferential Use of CXCR4 by R5X4 Human Immunodeficiency Virus Type 1 Isolates for Infection of Primary Lymphocytes
... of coreceptor utilization in general and the emergence of R5X4 variants in particular play an important role in ...SI primary isolates have the capacity to use both CCR5 and CXCR4 and thus exhibit an ... See full document
7
Impact of Cytokines on Replication in the Thymus of Primary Human Immunodeficiency Virus Type 1 Isolates from Infants
... HIV-1 primary isolates from infants obtained at or close to ...all primary isolates from infants were able to infect nonstimulated thymocytes freshly isolated from HIV-seronegative ... See full document
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Cytopathicity of Human Immunodeficiency Virus Type 1 Primary Isolates Depends on Coreceptor Usage and Not Patient Disease Status
... vivo human lymphoid histocultures, it has been established that X4 viruses are more cytopathic than R5 viruses (13, 14, 18) and specifically that late X4 viruses are more cytopathic than early R5 viruses ... See full document
6
Chemokine Coreceptor Usage by Diverse Primary Isolates of Human Immunodeficiency Virus Type 1
... subset usage by diverse, well-characterized primary viruses isolated from peripheral blood by monitoring viral replication with CCR1, CCR2b, CCR3, CCR5, and CXCR4 ...lines. Primary viruses were ... See full document
6
Neutralization Sensitivity of Human Immunodeficiency Virus Type 1 Primary Isolates to Antibodies and CD4-Based Reagents Is Independent of Coreceptor Usage
... T-tropic primary HIV-1 isolates are differentially sensitive to neutral- ization by MAbs or CD4-based reagents, or that coreceptor usage (CCR5 versus CXCR4) was a significant variable ... See full document
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Neutralization Profiles of Primary Human Immunodeficiency Virus Type 1 Isolates in the Context of Coreceptor Usage
... of human immunodeficiency virus type 1 (HIV-1) which have only been carried in vitro in peripheral blood mononuclear cells (primary isolates) can be neutralized by ... See full document
9
CCR5 and CXCR4 Usage by Non-Clade B Human Immunodeficiency Virus Type 1 Primary Isolates
... B isolates, including Q93 in ECL1 (28), Y184, S185, and R197 in ECL2 (17, 33), D276 and Q280 in ECL3 (17, ...test isolates were obtained from GenBank and ... See full document
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Functional Mimicry of a Human Immunodeficiency Virus Type 1 Coreceptor by a Neutralizing Monoclonal Antibody
... an amino acid (residue 440) from the fourth conserved region of gp120. These changes in gp120 have been shown to alter chemokine receptor preference (4, 8). The HXBc2(YU2V3) gly- coprotein, which contains the V3 loop of ... See full document
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