[PDF] Top 20 Cucurbit[n]uril binding of platinum anticancer complexes
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Cucurbit[n]uril binding of platinum anticancer complexes
... a platinum centre passing through an electronegative cucurbituril portal to effect encapsulation of the linking dpzm ...of platinum anticancer drugs are more toxic than the corresponding Cl form, the ... See full document
8
Multifaceted studies of the DNA interactions and in vitro cytotoxicity of anticancer polyaromatic platinum(II) complexes
... The LD spectrum of CT-DNA is characterised by a large negative band at ~260 nm. Upon the addition of each PC in this study, the band at 260 nm increased in intensity, which suggests a lengthening or stiffening of the DNA ... See full document
14
Eukaryotic cell toxicity and HSA binding of [Ru(Me4phen)(bb7)]2+ and the effect of encapsulation in cucurbit[10]uril
... protein binding can affect the distribution and clearance of a drug in several ways: only the free (non-protein bound) drug can act as an antimicrobial agent; alternatively, non-protein bound small drugs are ... See full document
12
Computer aided drug design of photoactivated platinum anticancer complexes
... the platinum adducts from DNA repair enzymes such as nucleotide excision repair (NER) proteins, which mainly recognize and excise intrastrand adducts, and increase the cytotoxicity of anticancer ... See full document
201
Use of Cucurbit [6] Uril as a Modifier in the Electrochemical Determination of Antitumor Platinum (II) Complex: Trans [PtCl2(Dimethylamine) (Isopropylamine)] Application to Biological Samples
... new platinum (II)- and platinum (IV)-based complexes have been synthesised and tested as anticancer drugs ...more platinum atoms co- ordinated to amine or ammine carrier ligands and ... See full document
9
Diazido platinum(IV) complexes for photoactivated anticancer chemotherapy
... those of its parent succinylated complex. 122 Another example of targeting for complex 13 is its conjugate with guanidinoneo- mycin, which is a RNA-binding ligand and allows the complex to be taken up by cancer ... See full document
16
Photodecomposition pathways for photoactivatable platinum(IV) diazido anticancer complexes
... identified binding of Pt II occurs preferentially at the N 7 atom of the purine nucleobase guanine (G), 51-56 forming the major 1,2-d(GpG) intrastrand cross links ... See full document
367
Photoactivatable platinum (IV) anticancer complexes
... Rh(III) complexes have been studied the most over the ...Ru-polypyridyl complexes which not only show intercalative properties via the ligand but also because the photoexcitated state is a strong oxidant, ... See full document
279
Diazido mixed amine platinum(IV) anticancer complexes activatable by visible light form novel DNA adducts
... of binding to calf- thymus (CT), plasmids, oligonucleotide DNA and individual nucleotides re- veals that photoactivated 1 and 2 form both mono- and bifunctional DNA le- sions, with preference for G and C, similar ... See full document
15
Study on the Application of Cucurbit[6]uril as a Nanoporous Adsorbent for the Removal of 2,4-Dinitrophenol from Wastewaters
... of cucurbit[6]uril as an alternative adsorbent for the removal of ...recently, cucurbit[n]urils (CB[n]s) have been widely investigated as novel molecular hosts ...their binding ... See full document
12
Unusual DNA binding modes for metal anticancer complexes
... DNA binding is the lack of severe DNA distortions such as a kink, or significant unwinding of the helices, which are characteristic of DNA adducts of mononuclear platinum ...central platinum unit ... See full document
73
Platinum(II) n heterocyclic carbene complexes : coordination and cyclometallation
... the reaction pathway that inhibits the reaction, rather than the inherent stability of the product. There are two widely accepted extremes of mechanisms for C-H activation reactions of this type: an oxidative addition ... See full document
11
Synthesis and structural dynamics of five coordinate Rh(III) and Ir(III) PNP and PONOP pincer complexes
... Pincer Complexes: Mechanistic Insight in Catalysis, Coordination, and Bond ...G. Platinum Group Organometallics Based on “Pincer” Complexes: Sensors, Switches, and ...Rh(III) Complexes: ... See full document
9
Synthesis, characterization, photochemistry and anticancer activity of novel photoactivatable platinum(IV) diazidodihydroxido complexes
... Pt complexes with different amines and anionic ...Pt anticancer drugs to make chemotherapy safer for patients, in particular, lessening severe side effects, 54, 55 increasing oral bioavailability, 52, 56 ... See full document
323
Design, Synthesis, and Reactivity of Bimetallic Complexes of Dimethylplatinum(II) Containing Ditopic Ligands
... Alkylplatinum(IV) complexes however have shown to overcome this detrimental property due to the stability of the Pt-C bonds towards protonolysis and as such these alkylplatinum(IV) complexes have given rise ... See full document
357
A hydrated co crystal of bis(μ oxo κ2O:O)bis[aquaoxodichloromolybdenum(VI)] with cucurbit[6]uril
... which the cryptand binds simultaneously to K and Zn ions. A water molecule is located within the barrel-shaped cryptand. Cucurbit[6]uril is the next larger member of this class of cryptands. The literature ... See full document
20
Palladium(II) and Platinum(II) complexes containing the mixed ligands N-phenyl-N-(2-pyridyl or 2-methylpyridyl) thiourea and diphosphines Ph2 P(CH2 )nPPh2 (n=1-4)
... chelated complexes [ML 2 ] with the diphosphines Ph 2 P(CH 2 ) n PPh 2 ; (n = 1 – 4) gave complexes of the type [ML 2 (diphos)] 2 , (n = 1) or [ML 2 (diphos)] (n = 2 – ... See full document
8
The new platinum-based anticancer agent LA-12 induces retinol binding protein 4 in vivo
... To understand the molecular mechanisms of LA-12 action and identify serum markers for LA-12 activity in cancer patients, we performed dose-response and time- course studies using mass-spectrometry-based analysis to ... See full document
9
Organometallic iridium(III) cyclopentadienyl anticancer complexes containing C,N chelating ligands
... C,N- complexes showed very promising anticancer activity toward A2780 human ovarian cancer ...Cp* complexes possess activity comparable to ...strong binding to guanine bases and ... See full document
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Platinum complexes of aromatic selenolates
... Rather unsurprisingly, given their similar coordination spheres, the bond distances in 3 and 5 are very similar throughout the complexes. The Pt-P bond lengths are similar at ~2.20 Å in 3 and ~2.19 Å in 5. The ... See full document
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