[PDF] Top 20 Development of gene expression-based risk score in cytogenetically normal acute myeloid leukemia patients
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Development of gene expression-based risk score in cytogenetically normal acute myeloid leukemia patients
... Acute myeloid leukemia (AML) is a cytogenetically and molecularly heterogeneous disease characterized by accumulation of a variety of somatically acquired genetic aberrations in myeloid ... See full document
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Original Article Overexpression of TIGAR predicts poor prognosis in elderly patients with cytogenetically normal acute myeloid leukemia (CN-AML)
... Elderly patients with acute myeloid leukemia (AML) have poor clinical outcomes and cyto- genetically normal (CN)-AML shows great ...TIGAR expression in elderly patients ... See full document
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Evaluation of BAALC gene expression in normal cytogenetic acute myeloid leukemia patients in north-east of Iran
... group. Patients were categorized to child and adult; the first one was ≤15 and con- sisted of 13 ...subjects. Patients’ mean±SD age was ...the patients' frequency based on mor- phologic ...of ... See full document
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TIGAR cooperated with glycolysis to inhibit the apoptosis of leukemia cells and associated with poor prognosis in patients with cytogenetically normal acute myeloid leukemia
... the expression of glycolytic enzymes ...high expression of TIGAR in human cancer may protect cancer cells from cell death ...TIGAR expression correlated with the increased tumor survival/burden, ... See full document
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MiR 362 5p as a novel prognostic predictor of cytogenetically normal acute myeloid leukemia
... and leukemia progression. In this study, we exam- ined the expression of miR-362-5p in a large cohort of 224 patients with CN-AML to analyze its prognostic ...classified patients into high and ... See full document
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High expression of inositol 1,4,5-trisphosphate receptor, type 2 ITPR2 ) as a novel biomarker for worse prognosis in cytogenetically normal acute myeloid leukemia
... Cytogenetically normal acute myeloid leukemia (CN-AML) constituting 40–50% of all AML patients is the largest cytogenetic group [1, ...with normal blood cells’ production ... See full document
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Identification and validation of potential prognostic gene biomarkers for predicting survival in patients with acute myeloid leukemia
... prognostic risk score model for patients’ survival prediction, the prognostic signature and cutoff point derived from the GSE12417 HG-U133A cohort were applied to the AML patients in the ... See full document
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Development and validation of GMI signature based random survival forest prognosis model to predict clinical outcome in acute myeloid leukemia
... Acute myeloid leukemia (AML) is a malignant disease of the bone marrow and typically represents functionally and phenotypically various cells in the same ...patient. Gene mu- tations ... See full document
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Prognostic Value of BAALC Expression in Pediatric Acute Myeloid Leukemia: A Systematic Review
... AML patients (3,6,7). However, in cytogenetically normal AML (CN AML), molecular abnormalities in nucleophosmin (NPM1), fms related tyrosine kinase 3 (FLT3), CCAAT/Enhancer-Binding Protein Alpha ... See full document
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Effect of mdr1 gene expression related to c3435t polymorphism in iraqi acute myeloid leukemia patients
... increased risk of susceptibility for diseases to half, because the mutant-T allele more disposed to environmental toxins and ...more risk to developing diseases and cancer (Mhaidat et ...AML patients ... See full document
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Low expression of T-cell transcription factor BCL11b predicts inferior survival in adult standard risk T-cell acute lymphoblastic leukemia patients
... BCL11b expression in the T-ALL GMALL patient cohort by quantitative ...lowest expression quartile (Q1; n = 49; BCL11b expression range = ...BCL11b expression levels defined as Q2-4 (n = 146; ... See full document
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<p>A six-gene-based prognostic model predicts complete remission and overall survival in childhood acute myeloid leukemia</p>
... a risk model to predict childhood AML ...High expression levels of SLC17A7, MSX2, CDC26 and DEFA3 were relevant to a poor prognosis in childhood AML patients, but MSLN and CTSZ were associated with a ... See full document
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Gene and protein analysis reveals that p53 pathway is functionally inactivated in cytogenetically normal Acute Myeloid Leukemia and Acute Promyelocytic Leukemia
... literature-based gene expression signatures further indicated that p53 is transcriptionally non-functional in CN-AML and APL blasts (Table ... See full document
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Quantitative Assessment of WT1 Expression by Real Time Quantitative PCR in Pediatric Patients with Acute Myeloblastic Leukemia
... distinct gene-expression signature among younger adults with de novo cytogenetically normal acute myeloid leukemia lacking FLT3 internal tandem ...and gene and ... See full document
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Mitogen-activated protein kinase binding protein 1 ( MAPKBP1 is an unfavorable prognostic biomarker in cytogenetically normal acute myeloid leukemia
... CN-AML patients, even after adjusting for most of known molecular risk ...the gene is widely expressed at a high level in CN-AML compared with normal BM, MAPKBP1 expression can be ... See full document
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High expression of RUNX1 is associated with poorer outcomes in cytogenetically normal acute myeloid leukemia
... CN-AML patients, even after adjusting for known molecular risk ...microarray expression data for LEF1 was in good agreement with quantitative real time PCR (qPCR) ...CN-AML patients than NBM, ... See full document
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An mRNA expression signature for prognostication in de novo acute myeloid leukemia patients with normal karyotype
... [33], our system-derived scores were moderately correlated with the scores from the two studies (correlation coefficients, 0.68 and 0.45, respectively, data not shown). Such concordance implies these prognostic scores, ... See full document
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Phase I clinical study of RG7356, an anti-CD44 humanized antibody, in patients with acute myeloid leukemia
... tested patients following RG7356 administration; however, this was not associated with hemolysis, except in 1 patient who presented with hemolysis exacerbation after the first ...data). Based on these data, ... See full document
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Pyridine nucleotide transhydrogenase in normal human and leukemic leukocytes
... The enzyme activity in the sediment of cells from patients with chronic lymphocytic, acute myeloid, and acute lymphocytic leukemia was significantly higher than that in cells from normal[r] ... See full document
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Successful management of disseminated Fusarium infection in a patient with acute myeloid leukemia
... During the pancytopenic period following the salvage cycle of chemotherapy, the patient developed recurrent episodes of fever which did not respond to the following antimicrobials: piperacillin-tazobactam, amikacin, ... See full document
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