[PDF] Top 20 Development of a Novel System To Study Hepatitis Delta Virus Genome Replication
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Development of a Novel System To Study Hepatitis Delta Virus Genome Replication
... of genome replication as supported by the small ␦ Ag ...HDV genome RNA and to produce new virus particles ...during replication to produce altered ␦ Ag species that are not supportive ... See full document
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Hepatitis Delta Antigen Regulates mRNA and Antigenome RNA Levels during Hepatitis Delta Virus Replication
... ABSTRACT Hepatitis delta virus (HDV) is a satellite of hepatitis B virus that in- creases the severity of acute and chronic liver ...circular genome; the circular anti- ... See full document
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Parameters of Human Hepatitis Delta Virus Genome Replication: the Quantity, Quality, and Intracellular Distribution of Viral Proteins and RNA
... HDV replication competence in each of these ...support virus replica- ...further study conclude whether or not the altered proteins will support ...HDV replication competence in the infected ... See full document
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Large Hepatitis Delta Antigen Is Not a Suppressor of Hepatitis Delta Virus RNA Synthesis once RNA Replication Is Established
... of hepatitis delta virus (HDV) replication is a likely prerequisite in the establishment of chronic infections and is thought to be mediated by the intracellular accumulation of large ... See full document
10
Transcription of Hepatitis Delta Antigen mRNA Continues throughout Hepatitis Delta Virus (HDV) Replication: a New Model of HDV RNA Transcription and Replication
... transfection system for the study of de novo RNA-templated synthesis of the full-length antigenomic HDV RNA and HDAg ...cDNA-transfected system, probably as a result of the inhibition of the ... See full document
8
Efficient inhibition of hepatitis B virus replication by hepatitis delta virus ribozymes delivered by targeting retrovirus
... Background: Hepatitis delta virus (HDV) ribozyme is an attractive molecular tool that can specifically recognize and catalyze the self-cleavage of the viral RNA phosphodiester ...this study ... See full document
6
Replication of the Human Hepatitis Delta Virus Genome Is Initiated in Mouse Hepatocytes following Intravenous Injection of Naked DNA or RNA Sequences
... HDV genome replication (10, 12, ...simian virus 40 late promoter to direct the transcription from DNA of a greater-than-unit-length species of antigenomic HDV RNA, the accumulation of unit-length ... See full document
5
Novel Function of CD81 in Controlling Hepatitis C Virus Replication
... and replication efficiency in cells with different CD81 expression levels, two cell populations, CD81-high (CD81-H) and CD81- low 1 (CD81-L1), containing 90% and 10% CD81-positive cells, respectively, were first ... See full document
12
Host RNA Polymerase Requirements for Transcription of the Human Hepatitis Delta Virus Genome
... nome replication was occurring with the pol II-specific inhib- itor ␣-amanitin ...HDV replication had been initiated via the stable transfection of the cells with a multimer of HDV cDNA; it was therefore ... See full document
9
Limitations to Replication of Hepatitis Delta Virus in Avian Cells
... Human hepatitis delta virus (HDV) is a natural subviral agent that uses hepatitis B virus as a ...woodchuck hepatitis B virus as a helper ...activity, replication ... See full document
6
Characterization of the 5′ Ends for Polyadenylated RNAs Synthesized during the Replication of Hepatitis Delta Virus
... The genome of hepatitis delta virus (HDV) is a 1,679-nucleotide (nt) single-stranded circular RNA that is predicted to fold into an unbranched rodlike ...During replication, two ... See full document
7
Replication of hepatitis delta virus RNA in mice after intramuscular injection of plasmid DNA.
... small-animal system for the study of human hepatitis delta virus (HDV) replication in vivo, plasmid DNAs containing head-to-tail cDNA dimers of HDV were inoculated intramuscu- ... See full document
5
Transcription Factor YY1 and Its Associated Acetyltransferases CBP and p300 Interact with Hepatitis Delta Antigens and Modulate Hepatitis Delta Virus RNA Replication
... Since replication of the HDV genome depends on cellular tran- scription machinery and is modulated by RNA polymerase II, B23, and nucleolin, it raises the possibility that HDAg interacts with these nuclear ... See full document
12
A novel form of hepatitis delta antigen.
... in genome replication is unlikely since , 2% of in- fected liver cells or transfected cells express this ...the virus includes the response to such ... See full document
5
Nucleotide sequence stability of the genome of hepatitis delta virus.
... of study, one that is probably more informa- tive, involves examining sequence changes that arise when the infection is known to begin with a single ...to study this for ...the delta antigen ...the ... See full document
6
Evolution of Hepatitis Delta Virus RNA Genome following Long-Term Replication in Cell Culture
... HDV genome replication, as now explained, we consider that there was also a positive selective pressure to maintain genome ...experimental system, each cell contains about 1,000 copies of HDV ... See full document
7
Genotype-Specific Complementation of Hepatitis Delta Virus RNA Replication by Hepatitis Delta Antigen
... of replication supported by HDAg from different genotype I isolates was remarkably greater than that observed among genotype III isolates, par- ticularly as the extents of sequence variation in a segment including ... See full document
9
Initiation of Hepatitis Delta Virus Genome Replication
... the virus binds to a susceptible cell via an as yet unidentified receptor, is inter- nalized, uncoated, and transported to the nucleus, and then RNA-directed RNA synthesis is somehow ...of genome ... See full document
6
Redistribution of the delta antigens in cells replicating the genome of hepatitis delta virus.
... To study colocalization of dAg or domain K with splicing factor SC35, mouse anti-SC35 antibody was used in combination with rabbit antibodies spe- cific for either total d Ag, d Ag-L, or domain ... See full document
7
A pseudoknot ribozyme structure is active in vivo and required for hepatitis delta virus RNA replication.
... of hepatitis delta virus (HDV) have so far been studied primarily in ...HDV replication cycle have not been ...HDV replication cycle in ...RNA replication. This study thus ... See full document
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