[PDF] Top 20 The effect of goal directed therapy on mortality in patients with sepsis earlier is better: a meta analysis of randomized controlled trials
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The effect of goal directed therapy on mortality in patients with sepsis earlier is better: a meta analysis of randomized controlled trials
... Our analysis also has several limitations that must be taken into consideration when interpreting the re- ...included trials had a high risk of bias (Figure ...subgroup analysis comparing ... See full document
10
Early goal-directed therapy in the management of severe sepsis or septic shock in adults: a meta-analysis of randomized controlled trials
... few meta-analysis studies to evaluate the effect of EGDT or a 6-h sepsis bundle including EGDT on patients with severe sepsis or septic shock ...previous meta- analyses ... See full document
12
Review Article Effects of goal directed therapy for adult patients in sepsis: a systemic review and meta-analysis of randomized controlled trials
... three trials, the ‘usual care’ appears to have early fluid ...the mortality benefit of GDT disap- ...overall mortality in patients with sep- ...these trials were insufficient to draw a ... See full document
12
Is perioperative goal-directed therapy able to reduce surgical complications in different surgical settings? A meta-analytic study
... Methods: Randomized controlled trials (RCTs) on perioperative GDT in adult surgical patients were ...of patients with a least one postoperative ...subgroup- analysis was also ... See full document
19
Echocardiogram-guided resuscitation versus early goal-directed therapy in the treatment of septic shock: a randomized, controlled, feasibility trial
... major trials of early sepsis ...patient-level meta-analysis of all patients enrolled in the “sepsis trilogy,” a median of 2 L fluid was administered prior to randomization ... See full document
8
The effect of glutamine therapy on outcomes in critically ill patients: a meta analysis of randomized controlled trials
... previous meta-analysis [17], glutamine supple- mentation reduced nosocomial infections among critically ill ...previous meta-analyses [17], we found that glutamine supplementation conferred no ... See full document
13
Effect of statin therapy on mortality from infection and sepsis: a meta analysis of randomized and observational studies
... protective effect from statins in patients with sepsis, and previous meta-analysis showed a similar outcome ...that analysis, no appropriate studies de- scribing the therapeutic ... See full document
13
Effect of perioperative goal directed hemodynamic therapy on postoperative recovery following major abdominal surgery—a systematic review and meta analysis of randomized controlled trials
... univariate meta-regression analyses were con- ducted when appropriate ...the patients (i.e., high- risk patients versus non-high-risk ...High-risk patients were defined as patients with ... See full document
17
<p>Effect of loading dose of atorvastatin therapy prior to percutaneous coronary intervention in patients with acute coronary syndrome: a meta-analysis of six randomized controlled trials</p>
... NSTE-ACS patients. Currently, a series of lipid-lowering trials have supported the concept “the lower, the ...ACS patients should receive high-intensity statin ...statin therapy, which is a ... See full document
8
The effects of goal directed fluid therapy based on dynamic parameters on post surgical outcome: a meta analysis of randomized controlled trials
... many patients because of limitations, which have been described in detail elsewhere [2], and do include small tidal volume (<8 ml/kg), open chest, sustained car- diac arrhythmia and abdominal hypertension (for ... See full document
11
Comparison of sedation strategies for critically ill patients: a protocol for a systematic review incorporating network meta-analyses
... Model adequacy of fit will be evaluated through compari- son of the posterior deviance with the number of uncon- strained data points (i.e., the total number of intervention arms across studies) [35], and adequacy of fit ... See full document
7
Original Article Protocolized sedation with dexmedetomidine in percutaneous nephrolithotomy: a randomized, controlled clinical trial
... anti-sympathetic effect and decreases the heart rate ...sedated patients in the study was lower than that in the control group pa- ...two patients in group D1, and in four patients in group ... See full document
6
Systematic review and meta-analysis of randomized controlled trials on Wenxin keli
... the meta-analysis, only two of them that had higher scores on the Jadad question- naire were used to evaluate the quality, thereby potentially affecting the strength of the ... See full document
12
Efficacy and safety of bevacizumab-based combination therapy for treatment of patients with metastatic colorectal cancer
... combination therapy is an emerging trend in metastatic colorectal cancer ...a meta-analysis of randomized controlled trials (RCTs) comparing bevacizumab-based combination ... See full document
17
The effectiveness of extra corporeal shock wave therapy for plantar heel pain: a systematic review and meta analysis
... placebo controlled trials [11,12,21,27,28,31-33]. Three trials used a low, sub-therapeutic dose as control ...two trials, [10,12], all excluded patients had the condition for less than ... See full document
11
How to Make a Mudsparkler
... on sepsis patients and compares time to intervention in the emergency department with the times outlined in the SSC ...of sepsis and the MEWS tool and to educate the staff on how to use the MEWS when ... See full document
137
Effect of postoperative goal directed therapy in cancer patients undergoing high risk surgery: a randomized clinical trial and meta analysis
... Consecutive patients who were 18 years old or more and scheduled for cancer surgery at the Cancer Institute were screened for ...enrolment. Patients undergoing high-risk surgery for cancer treatment (upper ... See full document
11
The effect of prone positioning on mortality in patients with acute respiratory distress syndrome: a meta analysis of randomized controlled trials
... trials reported the duration of PP only with medians and interquartile ranges. We estimated the means and variances based on the medians, ranges and sizes of the trials using the formulas recommended by ... See full document
10
Developing evidence-based dentistry skills: how to interpret randomized clinical trials and systematic reviews
... The randomized controlled clinical trial is a specific type of scientific experiment which is characterized by several dis- tinguishing ...of patients who are receiving the treat- ment under ... See full document
8
One year mortality of patients treated with an emergency department based early goal directed therapy protocol for severe sepsis and septic shock: a before and after study
... severe sepsis and septic shock in the ...12% mortality reduction among subjects treated with the protocol suggesting a number needed to treat (1/absolute mortality reduction) of approximately eight ... See full document
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