[PDF] Top 20 DNA minor groove binders-inspired by nature
Has 10000 "DNA minor groove binders-inspired by nature" found on our website. Below are the top 20 most common "DNA minor groove binders-inspired by nature".
DNA minor groove binders-inspired by nature
... Two molecules of this compound bind side-by-side in the minor groove however, MGBs containing one or more heterocyclic rings other than pyrrole 100 because of the bulky “isopropyl” of th[r] ... See full document
33
Ranking ligand affinity for the DNA minor groove by experiment and simulation
... the groove floor to achieve specificity, and to exploit the lipophilic nature of the groove walls to enhance ...the DNA duplex d(CGACTAGTCG) 2 and thiazotropsin A ... See full document
13
Four pyrrole derivatives used as building blocks in the synthesis of minor groove binders
... of minor-groove binders (MGBs) has expanded vastly and now these compounds display a wide spectrum of biological activities, such as anti- bacterial, antifungal, antiparasitic and anticancer ...the ... See full document
24
Design, synthesis and antibacterial activity of minor groove binders: the role of non-cationic tail groups
... to DNA but also penetration of the bacterial cell ...this minor groove binder rather than any intrinsic property of the ...Nevertheless, minor groove binders with both ... See full document
9
Thiazotropsin aggregation and its relationship to molecular recognition in the DNA minor groove
... the DNA minor groove and classical small molecule DNA binders including Hoechst 33258 [1-234567] berenil [8,9] netropsin [10] distamycin A [11,12] and their derivatives ( ...peptide ... See full document
37
Four pyrrole derivatives used as building blocks in the synthesis of minor-groove binders
... group. Both hydrogen-bonded ring motifs are approximately coplanar with molecular (I) and thus a two-dimensional supramolecular structure results with layers of molecules parallel to plane (101). Interactions between the ... See full document
25
Sequence-selective minor groove recognition of a DNA duplex containing synthetic genetic components
... impact minor groove ...other minor groove binders such as Hoechst33258 in complex with A-tract dsDNA ...uences groove width but also reduces allosteric modulation in a DNA ... See full document
9
Synthesis of New Series of Bis Benzothiazole Derivatives as DNA Minor Groove Binding Agents
... binding nature of the small molecules to ...of DNA due to its strong intercalation between the adjacent DNA base ...Many DNA minor groove agents could quench the intense ... See full document
6
Comparative effects of A.T and G.C sequence selective DNA minor groove binding agents
... of DNA cleavage over a wide range of ligand ...involving minor groove binders and DNA processing enzymes demonstrate inhibition of the proteins, there are some reports of an increase in ... See full document
227
Minor groove binders for DNA as antitypanosomal agents : the veterinary context
... to minor groove binding drugs from Strathclyde (S-MGBs) which is important because compounds useful in the field must have activity across the range of infectious species so that ... See full document
19
Superresolution imaging of single DNA molecules using stochastic photoblinking of minor groove and intercalating dyes
... phage DNA ( DNA) is a double-stranded template of 48,502 base pai rs with 12 base pair single stranded ‘sticky ends’ that allow for base-pairing type modifications at each ...and DNA repair ([10]). ... See full document
29
2D-IR spectroscopy shows that optimised DNA minor groove binding of Hoechst33258 follows an induced fit model
... in nature. 1 A structural hallmark of DNA is the anti-parallel helix where the major and minor grooves provide sites for sequence-selective binding of proteins and small ...double-stranded DNA ... See full document
24
Impact of pyrrolidine-bispyrrole DNA minor groove binding agents and chirality on global proteomic profile in Escherichia Coli
... target minor grooves of duplex DNA for controlling specific gene expression implicated in a ...of DNA. Yet, there is limited research on the chirality effect of minor groove ... See full document
9
Interaction of DNA with groove binding ligands
... Minor groove binding molecules usually have several simple aromatic rings (benzene, pyrrole etc) connected by bonds with torsional freedom that allow appropriate twisting to enable a good shape fit into the ... See full document
235
Site-specific interactions of JBP with base and sugar moieties in duplex J-DNA - Evidence for both major and minor groove contacts
... independent DNA footprinting methods, we find that JBP does not make any sequence-specific contacts with the bases surrounding the modified base ...and minor groove interactions at base J and a major ... See full document
8
Minor groove binders: some recent research in drug development
... to DNA in two ways: first through direct hydrogen bonds through the NH groups and second through water-mediated interactions with the ...the minor groove by increasing the number of hydrogen bond ... See full document
11
An evaluation of minor groove binders as anti-Trypanosoma brucei brucei therapeutics
... DNA binding as the proposed mechanism of action is strengthened considering that DNA binding correlates to some extent with trypanocidal activity [9 e 11]. The kinetoplast mini- circles of trypanosomes are ... See full document
10
Why antibacterial minor groove binders are a good thing
... MGB-BP-3 is a lipophilic molecule that is known to undergo self-association in aqueous solution. Self association of MGB-BP-3 and its relatives has been studied in detail by NMR spectroscopy (Parkinson et.al. Med. Chem. ... See full document
21
An evaluation of minor groove binders as anti-lung cancer therapeutics
... greater DNA binding affinity and in many contexts greater activity; therefore, it is interesting to note that these shorter compounds still are active against B16-F10 ... See full document
11
Selectivity in anti-infective minor groove binders
... feature that determines selectivity is access of the S-MGB to the DNA of the target organism which requires passing through the external cell membrane or cell wall. Experiments have shown that S-MGBs containing ... See full document
18
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