[PDF] Top 20 Do oxysterols control cholesterol homeostasis?
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Do oxysterols control cholesterol homeostasis?
... of cholesterol also argues that this oxysterol is not uniquely required for cholesterol ...of cholesterol synthesis by LDL, but another group has reached a different conclusion ...that ... See full document
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Relationship between oxysterols and mild cognitive impairment in the elderly: a case–control study
... four oxysterols, 27–OHC is the major choles- terol metabolite in the circulation and mainly produced from cholesterol in periphery and synthesized in almost all cells by the cytochrome P-450 enzyme CYP27A1 ... See full document
6
Cholesterol and ocular pathologies: focus on the role of cholesterol-24S-hydroxylase in cholesterol homeostasis
... Others oxysterols have been ...2005). Cholesterol-27-hydroxylase (CYP27A1) forms primar- ily 27-hydroxycholesterol and secondarily 7-hydroxy-3oxo-4- cholestenoic ...influence cholesterol synthesis by ... See full document
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Pioglitazone prevents cholesterol gallstone formation through the regulation of cholesterol homeostasis in guinea pigs with a lithogenic diet
... Liver and ileum were chopped into small pieces and homogenized in 0.5 ml of lysis buffer (phenylmethyl- sulfonyl fluoride (PMSF): RIPA = 1:9). The dissolved proteins were collected from the supernatant after ... See full document
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Abnormal vascularization in mouse retina with dysregulated retinal cholesterol homeostasis
... for blood vessels, tomato lectin (in red), which is a less specific blood-vessel marker than isolectin B4, binding to photoreceptors. (D, G, and L) Localization of GFAP, a marker of activated Müller cells (in yellow). ... See full document
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Liver LXRα expression is crucial for whole body cholesterol homeostasis and reverse cholesterol transport in mice
... of cholesterol (22, ...of cholesterol to bile acids (cholesterol 7α-hydroxy- lase), was absent in LivKO mice (Figure ...of control animals with T0901317 resulted in decreased expression of ... See full document
13
The hepatokine Tsukushi is released in response to NAFLD and impacts cholesterol homeostasis
... Inflammation and ER stress play crucial roles in promoting Tsk expression and release by the liver. Our observations indicate that these metabolic stresses, often present in the liver of obese patients (45, 46), could ... See full document
18
Copeptin, a surrogate marker for arginine vasopressin, is associated with cardiovascular risk in patients with polycystic ovary syndrome
... and control group. Results: Mean fasting insulin, homeostasis model assessment insulin resistance index (HOMA-IR), triglyceride, total cholesterol, low density lipoprotein cholesterol (LDL-C), ... See full document
6
Alterations in the homeostasis of phospholipids and cholesterol by antitumor alkylphospholipids
... in cholesterol trafficking (Figure 3): (1) ER, the major site of synthesis, regulation and esterification of cholesterol, (2) PM, a prominent storage site for unesterified cholesterol, and (3) endo- ... See full document
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Dual functions of Insig proteins in cholesterol homeostasis
... SREBP-1c control over fatty acid synthesis [11-13], whereas SREBP-2 favors cholesterol synthesis ...stimulate cholesterol synthesis ...the cholesterol biosynthetic pathway, and induce the ... See full document
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Liver X Receptors and their Agonists: Targeting for Cholesterol Homeostasis and Cardiovascular Diseases
... of cholesterol and certain bile acids, such as 22(R)- hydroxycholesterol (22R-OHC), 20(S)-hydroxy- cholesterol (20S-OHC), 24(S)-hydroxy- cholesterol (24S-OHC), 25-hydroxycholesterol (25-OHC), ... See full document
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Effect of dietary eicosapentaenoic and docosahexaenoic acid on expression of rat liver genes controlling cholesterol homeostasis and on plasma cholesterol level
... dogenous control in quantitative real-time PCR in the present study based on the results of the similar experiments measuring an effect of dietary PUFA n-3 on expression of genes controlling cholesterol ... See full document
8
Regulation of Intestinal Cholesterol Absorption: A Disease Perspective
... Cholesterol homeostasis in the body is maintained by de novo ...and cholesterol-containing chylomicron remnants, has been considered the major site of control in main- tenance of ... See full document
17
Of Vanishing Retinal Drusen and Oxysterols
... of cholesterol-lowering drugs (statins), antioxidant (dietary supplement formulated by the US National Eye Institute), and small epigenetic nutraceutical molecules (resveratrol, quercetin, phytate + vitamin D3 + ... See full document
12
Hepatitis C Virus Replication Depends on Endosomal Cholesterol Homeostasis
... LTP-mediated cholesterol transport through the endocytic pathway to the viral replication ...(A) Cholesterol-rich low-density lipoprotein (LDL) is taken up via receptor-mediated endocytosis and transported ... See full document
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Dysregulation of the Low-Density Lipoprotein Receptor Pathway Is Involved in Lipid Disorder-Mediated Organ Injury
... of cholesterol is high, the sterol sensor protein SCAP undergoes a conformational change that permits it to bind to Insig-1, which then forms SREBP-2/SCAP/Insig-1 ternary ...result, cholesterol uptake is ... See full document
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Effect of neonatal modulation of cholesterol homeostasis on subsequent response to cholesterol challenge in adult guinea pig
... or cholesterol 7 alpha-hydroxylase activity but resulted in a slight decrease in the hepatic 3-hydroxy-3-methylglutaryl-CoA reductase activity when they were challenged with a high cholesterol ...of ... See full document
10
Bauer_unc_0153D_14323.pdf
... form that must be cleaved by proteases such as caspase-1 or neutrophil elastase before release from the cell. We assessed pro-IL-1β (Il1b) gene expression in lung homogenates and found no effect of HDM or caspase-1 ... See full document
248
Altered Cholesterol Homeostasis in Aged Macrophages Linked to Neovascular Macular Degeneration
... that cholesterol homeostasis via ABCA1 in aging macrophages is important for ...targeting cholesterol trafficking in inflammatory cells in ... See full document
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Niemann Pick C1 protects against atherosclerosis in mice via regulation of macrophage intracellular cholesterol trafficking
... phages exhibited accelerated atherosclerosis despite lower serum cholesterol compared with mice reconsti- tuted with wild-type macrophages. The discordance between the low serum lipoprotein levels and the presence ... See full document
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