[PDF] Top 20 E2F-1 has dual roles depending on the cell cycle
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E2F-1 has dual roles depending on the cell cycle
... CMV E2F-1 was used to express E2F-1/wt and E2F-1/mutant genes as described ...CMV E2F-1 is identical to Linker CMV T ...encoding E2F-1/wt [25] or ... See full document
13
Adenoviral delivery of E2F 1 directs cell cycle reentry and p53 independent apoptosis in postmitotic adult myocardium in vivo
... the cell cycle precludes the ability of cardiac muscle cells to increase cell number after ...demonstrated dual pocket protein– and p300-dependent pathways in neonatal rat cardiac myocytes, ... See full document
8
PEG10 overexpression induced by E2F-1 promotes cell proliferation, migration, and invasion in pancreatic cancer
... PC cell proliferation and the underlying mechanism. PEG10 has been reported to promote cancer cell proliferation through mechanisms described as ...in cell death as in hepatocellular ... See full document
12
Pegylated arginine deiminase synergistically increases the cytotoxicity of gemcitabine in human pancreatic cancer
... during cell cycle progression is well understood, the regu- lation of cellular level of the protein subunits is less well ...it has been frequently observed that RRM2 is upregulated following ... See full document
12
Activation of Notch1 signaling alleviates dysfunction of bone marrow-derived mesenchymal stem cells induced by cigarette smoke extract
... of cell cycle- related proteins and determined that the expression levels of cyclin D1, p-Rb, and E2F-1 (Figure 3C and D) increased, while that of p21 decreased in N1ICD overexpressing MSCs ... See full document
15
Biochemical characterisation of the eukaryotic cell cycle regulatory proteins, E2F and pRB
... in cell lines lacking BRGl, while ectopic expression of BRGl in these cells restores the tumour suppressor’s ability to effect such repression (Strobeck et ai, ...BRM has been shown to cooperate with pRb, ... See full document
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E2F-1 binding affinity for pRb is not the only determinant of the E2F-1 activity
... express E2F-1/wt and E2F-1/mutant genes as described ...CMV E2F-1 is identical to Linker CMV T [18] except that the large T antigen gene from simian virus 40 was replaced by a ... See full document
14
Irreversibility of cellular senescence: dual roles of p16INK4a/Rb-pathway in cell cycle control
... complete cell cycle, suggesting that these cells may be arrested in G2 or M phase of the cell cycle ...independent cell cycle block, which seems to be specific for human cells, ... See full document
5
Dual roles for macrophages in ovarian cycle associated development and remodelling of the mammary gland epithelium
... with 1:50 anti-F4/80 rat monoclonal antibody (Caltag Laboratories, Burlingame, CA, USA) overnight at 4°C or with isotype-matched irrelevant antibody as a negative control, followed by 1:100 biotinylated ... See full document
10
Cdks, cyclins and CKIs: roles beyond cell cycle regulation
... in cell cycle control to become regulators of ...of E2F proteins complements its effect on Cdk/cyclin complexes to augment the repression of E2F-responsive genes and induce efficient ... See full document
15
Dual Roles for Yeast Sti1/Hop in Regulating the Hsp90 Chaperone Cycle
... ing the mutant versions of Hsp82 as the only source of Hsp90 to study further. All of the Hsp82 mutants exhibited growth defects compared with cells expressing wild-type Hsp82, in particular regarding sensitivity to both ... See full document
16
Original Article FRS2 promotes the progression of non-small cell lung cancer
... including cell differentiation, proliferation, migration, and apoptosis [5, ...signaling has been linked to can- cer progression and was shown to affect cancer origination, angiogenesis, and metastasis of ... See full document
8
Parkinson’s disease-associated protein Parkin: an unusual player in cancer
... In addition to regulating cell cycle, Parkin also regulates mitosis. Parkin interacts with anaphase-promoting com- plex/cyclosome (APC/C) co-activators Cdc20 and Cdh1 to mediate the degradation of several ... See full document
8
Promiscuous and lineage-specific roles of cell cycle regulators in haematopoiesis
... single cell organisms, such as yeast, one cyclin depend- ent kinase (CDK) is enough to mediate cell cycle progres- ...of cell cycle regulators, including multiple CDKs, cyclins, and CDK ... See full document
9
Emerging Roles for Ciz1 in Cell Cycle Regulation and as a Driver of Tumorigenesis
... of cell division cycle 6 (Cdc6), chromatin licensing and DNA replication factor 1 (Cdt1) and mini-chromosome maintenance 2-7 (Mcm2-7) in an ATP-dependent manner [20–22] completing formation of ... See full document
15
GADD45 induction by S-adenosylmethionine inhibits hepatocellular carcinoma cell proliferation during acute ischemia-hypoxia
... influences cell growth, apoptosis and cellular response to DNA damage, is downregulated in hepatocellular carcinoma ...the roles of GADD45β and SAMe in cell survival during acute ischemia-hypoxia ... See full document
11
Cryptotanshinone has diverse effects on cell cycle events in melanoma cell lines with different metastatic capacity
... The cell cycle is a critical regulator of the processes involved in cell proliferation and growth, as well as cell division after DNA ...perturbing cell cycle-related events, a ... See full document
19
Characterisation of a cellular transcription factor which co-ordinates cell cycle events with transcription
... this has not been identified although the MAP (mitogen activated protein) kinases are good candidates as they can phosphorylate the same sites in vitro that are phosphorylated in vivo (Pulverer et ...observation ... See full document
305
D-type Cyclins, Epidermal Patterning and Their Roles in Geminivirus and Cell Cycle Interface
... the cell cycle, one of the most disadvantageous things that can happen to a cell is the improper replication of its DNA into its daughter ...to cell cycle ... See full document
82
Huber, Elisabeth (2018): The schlafen core domain: from structure to function. Dissertation, LMU München: Fakultät für Chemie und Pharmazie
... section 4.1.1.2), showed differences in activity on single-stranded 60- mer poly (dT) DNA. For wild type batch ‘Q1’, digestion is completed after 45 minutes, whereas for wild type batch ‘Q2’ and ‘Q3’ the substrate is ... See full document
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