[PDF] Top 20 Early goal directed and lactate guided therapy in adult patients with severe sepsis and septic shock: a meta analysis of randomized controlled trials

... Our meta-analysis showed that a 6-h EGDT protocol for patients with severe sepsis or septic shock resulted in lower mortality than UC, especially in severely ill ...that ... See full document

... Surviving Sepsis Campaign guidelines have proposed early goal-directed therapy (EGDT) as a key strategy to decrease mortality among patients with severe sepsis or ... See full document

... sequential analysis of all-cause mortality in patients with severe sepsis and septic shock of ProCESS, ARISE and ...of early goal-direced therapy on ... See full document

... surgical patients [5, 6], and we wonder to know its ben- efit in critically ill patients with ...ized controlled trials to test the hypothesis that GDT gain the mortality ...subgroup ... See full document

... Goal-directed therapy (GDT) has been shown to substan- tially improve clinical outcomes in surgical patients ...include early initiation of the therapeutic measures, together with ... See full document

... of Controlled Trials and Web of Science ...crystalloid therapy on mortality in adult patients with severe sepsis and septic ...the patients with ... See full document

... (ICU)-based randomized controlled feasibility trial comparing echocardiography-guided septic shock resuscitation (ECHO) with early goal-directed therapy ... See full document

... for early management of severe sepsis and septic shock in the emergency ...called early goal-directed therapy was compared to standard care and this clinical ... See full document

... to severe sepsis and septic shock involves a myriad of pathogenic changes, including circulatory abnormalities that result in global tissue ...of goal- directed hemodynamic ... See full document

... for early management of severe sepsis and septic shock in the emergency ...called early goal-directed therapy was compared to standard care and this clinical ... See full document

... of Controlled Trials, ...be randomized controlled clinical trials or cohort studies which compare procalcitonin-guided therapy with standard care in severe ... See full document

... such patients attend the ED in different health care systems, institutions, or geographical settings, and on their mortality outside the single institution in which the EGDT trial was ...a sepsis team, ... See full document

... curve analysis supported the usefulness of this ...including lactate, heart rate, and autonomic dysfunction ...stratify patients according to the severity of disease, even after the patients ... See full document

... of patients with ...263 patients enrolled in a randomized controlled trial in ...of sepsis, Rivers et al7 were able to decrease absolute inhospital mortality rate by ...termed ... See full document

... a randomized controlled trial which aims to determine if a peripheral perfusion‑ targeted resuscitation is associated with lower 28‑day mortality compared to a lactate‑targeted resuscitation in ... See full document

... a randomized controlled trial which aims to determine if a peripheral perfusion‑ targeted resuscitation is associated with lower 28‑day mortality compared to a lactate‑targeted resuscitation in ... See full document

... Abstract Severe sepsis and septic shock are among the leading causes of mortality in the intensive care ...ago, early goal-directed therapy (EGDT) emerged as a ... See full document

... Severe sepsis and septic shock are among the leading causes of mortality in the intensive care ...ago, early goal-directed therapy (EGDT) emerged as a novel ... See full document

... of sepsis include hemodynamic optimization with early goal-directed therapy (EGDT) during the pre-intensive care period, especially in the emergency department ...to early ... See full document

... included trials differed in terms of sample size, disease severity, source of infection, and durations and sessions of polymyxin B ...outcome analysis of mortality showed high levels of statistical ... See full document