[PDF] Top 20 The effect of deleterious mutations on neutral molecular variation.
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The effect of deleterious mutations on neutral molecular variation.
... Approximate formulas are derived for the reduction below classical neutral values resulting from such background selection against deleterious mutations, for the mean times [r] ... See full document
15
Hypermutability in Asexuals: Investigating the Effects of Deleterious Mutations
... indirect effect on fitness by reducing the rate at which deleterious mutations accumulate, and that such an effect may be strong enough to drive these alleles to fixation, I performed computer ... See full document
98
Effect of Selection Against Deleterious Mutations on the Decline in Heterozygosity at Neutral Loci in Closely Inbreeding Populations
... the effect of selection against deleterious mutations on the process of inbreeding at a linked neutral ...the neutral and selected loci and the inbreeding depression from the selected ... See full document
15
The Effect of Antagonistic Pleiotropy on the Estimation of the Average Coefficient of Dominance of Deleterious Mutations
... new mutations were sam- pled from a gamma ...be deleterious for this fitness com- ...these mutations could also have a pleiotropic effect on other fitness components, and this effect ... See full document
16
The Effects of Deleterious Mutations on Linked, Neutral Variation in Small Populations
... the effect of deleterious mutations have clear limitations when applied to small ...a deleterious mutant allele at lo- cus, i, q i ! (hs i 1 r i (1 2 hs i ))N e ... See full document
9
The Effect of Overdominance on Characterizing Deleterious Mutations in Large Natural Populations
... dominance. Mutations ters of deleterious genomic mutations determine the with (over)dominant effects are referred to as (over)- mutation load in populations at equilibrium (Haldane dominant ... See full document
19
Expected Effect of Deleterious Mutations on Within-Host Adaptation of Pathogens
... the effect of the immune response and antiviral ...requires deleterious intermediate mutations, fitness ridges and valleys arise in the pathogen’s fitness ...The effect of deleterious ... See full document
10
Population Growth Inflates the Per-Individual Number of Deleterious Mutations and Reduces Their Mean Effect
... joint effect of natural selection and population growth on deleterious alleles is not trivial to understand since these two forces have opposite effects: purifying selection purges deleterious ... See full document
32
The Effects of Deleterious Mutations on Evolution at Linked Sites
... on variation and the efficacy of se- ...nonsynonymous mutations is higher in the outcrossing plant Capsella grandi- flora than in the related selfer ... See full document
18
Dynamics and Fate of Beneficial Mutations Under Lineage Contamination by Linked Deleterious Mutations
... beneficial mutations (Charlesworth et ...linked deleterious mutations (Birky and Walsh 1988; Bachtrog and Gordo 2004; Hartfield et ...and deleterious mutations is the number of delete- ... See full document
14
Influence of Dominance, Leptokurtosis and Pleiotropy of Deleterious Mutations on Quantitative Genetic Variation at Mutation-Selection Balance
... and effect), estimates of dominance coefficients are imprecise (Lynch et ...new mutations (Lynch and Walsh 1998; Vassilieva et ...new mutations from published esti- mates of mean dominance ... See full document
14
Characterization of Deleterious Mutations in Outcrossing Populations
... genotypes under the assumption that genotypic values tions are often sheltered from selection by being kept are measured without error. This assumption will be in heterozygous state in outcrossing populations. To relaxed ... See full document
12
Beneficial Mutations, Hitchhiking and the Evolution of Mutation Rates in Sexual Populations
... small effect. Linkage disequilibrium be- tween sets of loci at which mutations occur can then be ignored, and only the two-way linkage disequilibrium between each mutable locus and the modifier needs to be ... See full document
12
Testing for Epistasis Between Deleterious Mutations
... which deleterious mutations interact in their effects on fitness is crucial to numerous areas in population genetics and evolutionary ...between deleterious mutations in haploid species have ... See full document
10
On the Average Coefficient of Dominance of Deleterious Spontaneous Mutations
... viability mutations in Drosophila ...of deleterious mutations, with h ≈ ...spontaneous mutations using parameters in the literature, we investigate the above ...few mutations with ... See full document
11
The pattern of neutral molecular variation under the background selection model.
... Infinite sites population model: The approximate analytical results generated previously suggested that, at least with low mutation rates, no difference in the effect [r] ... See full document
14
Weakly Deleterious Mutations and Low Rates of Recombination Limit the Impact of Natural Selection on Bacterial Genomes
... the variation in diversity could reflect stronger selection on synonymous codons in highly expressed genes, so that they have fewer effectively neu- tral ... See full document
10
Epistasis and the Adaptability of an RNA Virus
... (1) mutations with varying deleterious fitness effects, (2) one or two deleterious mutations, and (3) pairs of mutations showing differences in the strength and sign of ...that ... See full document
8
The dynamic clonal genome and its adaptive potential
... mildly deleterious (Ohta, ...of deleterious mutations in small populations of asexual endosymbionts, as predicted from Muller’s ratchet (Moran, ... See full document
17
Evidence for Abundant Slightly Deleterious Polymorphisms in Bacterial Populations
... nearly neutral theory of molecular evolution predicts that slightly deleterious mutations subject to purifying selection are widespread in natural populations, particularly those of large ... See full document
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