[PDF] Top 20 Effects of Amino Acid Substitutions at Position 115 on the Fidelity of Human Immunodeficiency Virus Type 1 Reverse Transcriptase
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Effects of Amino Acid Substitutions at Position 115 on the Fidelity of Human Immunodeficiency Virus Type 1 Reverse Transcriptase
... genetic fidelity assays use normal poly- merase substrates in which the template primer is fully base paired and all four dNTPs are present at normal concentra- ...genetic fidelity assays are without ... See full document
7
Influence of Reverse Transcriptase Variants, Drugs, and Vpr on Human Immunodeficiency Virus Type 1 Mutant Frequencies
... single-amino-acid substitutions in RT can change HIV-1 mutant frequencies and that these effects are influenced by additional mutations in RT, by drugs, and by Vpr variants deficient ... See full document
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Cross-Linking of the Fingers Subdomain of Human Immunodeficiency Virus Type 1 Reverse Transcriptase to Template-Primer
... the position of the nucleic acid substrate relative to ...the amino acids in the fingers where there are mutations that are associated with nucleoside analog resistance in direct contact with the ... See full document
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Effects of Human Immunodeficiency Virus Type 1 Resistance to Protease Inhibitors on Reverse Transcriptase Processing, Activity, and Drug Sensitivity
... considerable effects on viral rep- lication. The three virus pairs studied here were characterized by a strong difference in infectivity between the pretherapy and post resistance protease-reconstructed ... See full document
5
Comparison of Sequencing by Hybridization and Cycle Sequencing for Genotyping of Human Immunodeficiency Virus Type 1 Reverse Transcriptase
... the position of interest or at nearby positions which affect hybridization constituted a major cause of discordance in population ...ambiguous amino acid determinations by cycle sequencing, a rate ... See full document
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Hypersusceptibility to Substrate Analogs Conferred by Mutations in Human Immunodeficiency Virus Type 1 Reverse Transcriptase
... Human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) contains four structural motifs (A, B, C, and D) that are conserved in polymerases from ... See full document
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Augmentation of Human Immunodeficiency Virus Type 1 Subtype E (CRF01_AE) Multiple-Drug Resistance by Insertion of a Foreign 11-Amino-Acid Fragment into the Reverse Transcriptase
... A human immunodeficiency virus type 1 (HIV-1) subtype E (CRF01_AE) variant (99JP-NH3-II) possessing an in-frame 33-nucleotide insertion mutation in the  3-  4 loop coding ... See full document
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The Impact of Multidideoxynucleoside Resistance-Conferring Mutations in Human Immunodeficiency Virus Type 1 Reverse Transcriptase on Polymerase Fidelity and Error Specificity
... to type I error. The Q151 residue in HIV-1 RT maps to the loop between the aE and b8 region of the RT, near the single-stranded DNA of the tem- plate base (30), and is proposed to make contact with the ... See full document
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Mutational analysis of the fingers domain of human immunodeficiency virus type 1 reverse transcriptase.
... The mutations are primarily single amino acid substitutions, but some involve 7533 Downloaded from http://jvi.asm.org/ on November 9, 2019 by guest Using BspMI cassette vectors, we have [r] ... See full document
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Increased Multinucleoside Drug Resistance and Decreased Replicative Capacity of a Human Immunodeficiency Virus Type 1 Variant with an 8-Amino-Acid Insert in the Reverse Transcriptase
... specific amino acid substitutions, rather than insertions or deletions, in reverse transcriptase (RT) of human immunodeficiency virus type 1 ...the ... See full document
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Effects of zidovudine-selected human immunodeficiency virus type 1 reverse transcriptase amino acid substitutions on processive DNA synthesis and viral replication.
... Certain amino acid substitutions in the reverse transcriptase (RT), including D67N, K70R, T215Y, and K219Q, cause high-level resistance of human immunodeficiency ... See full document
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Amino Acid Substitutions at Position 190 of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Increase Susceptibility to Delavirdine and Impair Virus Replication
... aa 1 to ...patient virus in plasma, RTVs were prepared and tested as large pools ...leukemia virus. High-titer virus stocks were harvested 48 h after transfection and used to infect fresh 293 ... See full document
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Significance of amino acid variation at human immunodeficiency virus type 1 reverse transcriptase residue 210 for zidovudine susceptibility.
... in human immunodeficiency virus (HIV) infection to delay the development of AIDS and to increase survival of patients with AIDS (4, 9, ...five amino acid changes (at residues 41, 67, ... See full document
5
Mutations in the Thumb Allow Human Immunodeficiency Virus Type 1 Reverse Transcriptase To Be Cleaved by Protease in Virions
... during human immu- nodeficiency virus type 1 (HIV-1) replication, most mutations are rapidly lost because they have a negative effect on viral ...HIV-1 reverse ... See full document
9
Coreceptor Tropism Can Be Influenced by Amino Acid Substitutions in the gp41 Transmembrane Subunit of Human Immunodeficiency Virus Type 1 Envelope Protein
... To evaluate the impact of V3 and non-V3 env regions on CXCR4 use, we constructed a panel of chimeric env clones by exchanging the V3 regions between the R5-tropic clone 10R and three other CXCR4-using clones that had ... See full document
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Human Immunodeficiency Virus Mutagenesis during Antiviral Therapy: Impact of Drug-Resistant Reverse Transcriptase and Nucleoside and Nonnucleoside Reverse Transcriptase Inhibitors on Human Immunodeficiency Virus Type 1 Mutation Frequencies
... ⫺ 1, ⫺ 2, and ⫹ 1 frameshift mutations and dislocation mutagenesis of HIV-1 RT ...replication fidelity are generated during the catalytic cycle of the various polymerases, in which there are ... See full document
13
Amino Acid Deletion at Codon 67 and Thr-to-Gly Change at Codon 69 of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Confer Novel Drug Resistance Profiles
... We have previously reported that the T69G mutation led to ddI resistance in an AZT-resistant backbone and was associ- ated with impaired HIV replication (8). Emergence of the ⌬67 deletion and the L74I change in the RT ... See full document
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Involvement of Novel Human Immunodeficiency Virus Type 1 Reverse Transcriptase Mutations in the Regulation of Resistance to Nucleoside Inhibitors
... in human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) whose role in drug resistance is still unknown by analyzing 1,906 plasma-derived ... See full document
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Reduced Susceptibility of Human Immunodeficiency Virus Type 1 (HIV-1) from Patients with Primary HIV Infection to Nonnucleoside Reverse Transcriptase Inhibitors Is Associated with Variation at Novel Amino Acid Sites
... primary human immunodeficiency virus (HIV) infection have been found to harbor viral strains with reduced susceptibility to antiretroviral ...nonnucleoside reverse transcriptase (RT) ... See full document
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Quantification of the Effects on Viral DNA Synthesis of Reverse Transcriptase Mutations Conferring Human Immunodeficiency Virus Type 1 Resistance to Nucleoside Analogues
... a virus expressing the D67N ⫹ K70R ⫹ T215Y ⫹ K219Q combination of TAMs was actually superior to that of WT virus under conditions thought to be associated with small dNTP pools ... See full document
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