[PDF] Top 20 Effects of long terminal repeat mutations on human immunodeficiency virus type 1 replication.
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Effects of long terminal repeat mutations on human immunodeficiency virus type 1 replication.
... About five times more reverse transcriptase activity was recovered from Jurkat cells that had been transfected with the provirus deleted for the NRE sequence 1,372,900 more virus was rel[r] ... See full document
5
Opposite Effects of SDF-1 on Human Immunodeficiency Virus Type 1 Replication
... SDF-1 does not affect the efficiency of reverse transcription. The amount of newly reverse-transcribed proviral DNA was monitored. P4C5 cells were preincubated for 30 min at 37°C with or without SDF-1 (200 ... See full document
8
Interactions of thyroid hormone receptor with the human immunodeficiency virus type 1 (HIV-1) long terminal repeat and the HIV-1 Tat transactivator.
... factor (Ro factor) may be involved in these responses. Ro 5-3335 and T3 activated p(2167/121)-CAT synergistically, in- dicating that the TAR sequence is not required for the activity of the Ro factor. Inhibition of Tat ... See full document
10
IRF-1 Is Required for Full NF-κB Transcriptional Activity at the Human Immunodeficiency Virus Type 1 Long Terminal Repeat Enhancer
... mutated. Mutations in either the proximal or the distal B site also greatly impaired the basal transcriptional ...(lane 1), and overexpression of IRF-1 (lane 2) led to the appearance of a major ... See full document
10
A model system for human cytomegalovirus-mediated modulation of human immunodeficiency virus type 1 long terminal repeat activity in brain cells.
... DNA replication, is required for the activa- tion suggests that HCMV immediate-early- or early-gene prod- ucts must be ...the effects observed in a simplified system may not accu- rately reflect the in vivo ... See full document
9
Deletion Mutagenesis Downstream of the 5′ Long Terminal Repeat of Human Immunodeficiency Virus Type 1 Is Compensated for by Point Mutations in both the U5 Region and gag Gene
... point mutations in rescuing the decreased infectiousness of mutated ...point mutations. Viral proteins in cell lysates and virus particles were analyzed by Western blotting through the use of ... See full document
11
The Human Factors YY1 and LSF Repress the Human Immunodeficiency Virus Type 1 Long Terminal Repeat via Recruitment of Histone Deacetylase 1
... YY1 is known to interact with a number of cellular factors via a Gly/Ala-rich region within residues 154 to 199 (2). LSF, however, interacts with the zinc finger domain of YY1. The Gly/Ala domain was present on all ... See full document
10
C/EBP proteins activate transcription from the human immunodeficiency virus type 1 long terminal repeat in macrophages/monocytes.
... Three binding sites for C/EBP proteins are found in the human immunodeficiency virus type 1 (HIV-1) long terminal repeat (LTR) (V. M. Tesmer, A. ... See full document
8
Effects of Mutations in the G Tract of the Human Immunodeficiency Virus Type 1 Polypurine Tract on Virus Replication and RNase H Cleavage
... nearly correct. As a consequence, the population of linear viral DNAs that become ligated to form 2-LTR circles preferen- tially contains aberrant ends. In order to analyze the entire population of linear viral DNAs, we ... See full document
10
Effects of the tat and nef gene products of human immunodeficiency virus type 1 (HIV-1) on transcription controlled by the HIV-1 long terminal repeat and on cell growth in macrophages.
... Contrary to claims that the activity of the HIV-1 LTR responds poorly in rodent cells to trans activation by the viral tat gene product, cotransfection of RAW264 cells with a tat express[r] ... See full document
9
Expression of a human immunodeficiency virus type 1 long terminal repeat/simian virus 40 early region fusion gene in transgenic mice.
... We investigated the in vivo tissue specificity of the HIV-1 transcription control elements by introducing a hybrid reporter gene containing the HIV-1 LTR fused to the simian virus 40 SV4[r] ... See full document
9
Evolution of human immunodeficiency virus type 1 nef and long terminal repeat sequences over 4 years in vivo and in vitro.
... 225 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest The evolution of an 851-bp segment of the human immunodeficiency virus type 1 HIV-1 genome encoding the nef open rea[r] ... See full document
7
In vivo footprinting analysis of constitutive and inducible protein-DNA interactions at the long terminal repeat of human immunodeficiency virus type 1.
... Involvement of the HIV-1 enhancer in transcriptional activation of HIV-1 by mitogens and cytokines has already been observed in different experimental systems by in vitro protein binding[r] ... See full document
11
Functional Differences between the Long Terminal Repeat Transcriptional Promoters of Human Immunodeficiency Virus Type 1 Subtypes A through G
... between virus subtype, biological properties, and pathogenicity is unknown, in part because virus replication studies have been performed almost exclusively with subtype B ... See full document
12
TFII-I Regulates Induction of Chromosomally Integrated Human Immunodeficiency Virus Type 1 Long Terminal Repeat in Cooperation with USF
... Human immunodeficiency virus type 1 (HIV-1) replication is coupled to T-cell activation through its dependence on host cell transcription ...ⴕ long terminal ... See full document
11
Activation of the human immunodeficiency virus type 1 long terminal repeat by vaccinia virus.
... To investigate whether vaccinia virus induces HIV LTR-directed gene expression, transient expression assays in Jurkat cells persistently infected with vaccinia virus Jvac using plasmid D[r] ... See full document
6
The kappaB sites in the human immunodeficiency virus type 1 long terminal repeat enhance virus replication yet are not absolutely required for viral growth.
... of human immunodeficiency virus type 1 (HIV-1) gene expression ...primary human T cells (13) and is also found at high levels in cultured monocytes; these are the two ... See full document
10
Targeted Derepression of the Human Immunodeficiency Virus Type 1 Long Terminal Repeat by Pyrrole-Imidazole Polyamides
... In summary, we show that RCS-binding polyamides targeted to the HIV LTR can inhibit LSF binding to the RCS in vitro and can increase expression of the LTR. RCS-binding poly- amides selectively upregulate expression of ... See full document
6
Multiple effects of mutations in human immunodeficiency virus type 1 integrase on viral replication.
... transfer in vitro (7, 43, 52), whereas the core domain is suffi- cient for disintegration activity (4, 32). The core domain is composed of two subdomains; one part, originally identified as a relatively protease ... See full document
8
The control of human immunodeficiency virus type 1 long terminal repeat promoter activity by retinoic acid
... (a human kidney derived cell line) transfected with RAR a expression vector was used as a source of RAR a ...Lane 1 contains the control RARE probe and RAR a ... See full document
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