[PDF] Top 20 Efficient Rescue of Hepatitis C Virus RNA Replication by trans-Complementation with Nonstructural Protein 5A
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Efficient Rescue of Hepatitis C Virus RNA Replication by trans-Complementation with Nonstructural Protein 5A
... the replication-competent helper RNA carried the neo gene to allow discrimination between the two RNA species ...Methods), replication of the mutant was determined at 4, 24, 48, and 72 h ... See full document
The FUSE Binding Protein Is a Cellular Factor Required for Efficient Replication of Hepatitis C Virus
... Hepatitis C virus (HCV) infection is the leading cause of liver cirrhosis and hepatocellular carcinoma and one of the primary indications for liver ...HCV replication remain poorly defined. ... See full document
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Pim Kinase Interacts with Nonstructural 5A Protein and Regulates Hepatitis C Virus Entry
... epatitis C virus (HCV) is a major etiological agent of chronic liver disease, including cirrhosis and hepatocellular carci- noma ...enveloped virus with a positive-sense, single-stranded RNA ... See full document
14
Intragenic Complementation of Hepatitis C Virus NS5A RNA Replication-Defective Alleles
... for replication of the JFH1 ...with replication being facilitated by phosphorylation of these ...same replication-null phenotype as a replicon with an S229A substitution, indicating that introduction ... See full document
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Conserved Determinants for Membrane Association of Nonstructural Protein 5A from Hepatitis C Virus and Related Viruses
... GB virus A (GBV-A), GBV-B, and ...strand RNA viruses express their structural and nonstructural proteins via translation of a single long open reading frame ...(30). Hepatitis C ... See full document
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Interaction of Hepatitis C Virus Nonstructural Protein 5A with Core Protein Is Critical for the Production of Infectious Virus Particles
... HCV RNA replica- ...serine/threonine protein kinases that block NS5A hyperphosphorylation facili- tate replication of a non-culture-adapted replicon (3, ...HCV RNA replication by ... See full document
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The Hepatitis C Virus NS4B Protein Can trans-Complement Viral RNA Replication and Modulates Production of Infectious Virus
... studies, trans-complementation of RNA replica- tion could be achieved only with NS5A and not with any other HCV NS protein, including NS4B (2, ...block replication demonstrates that ... See full document
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Characterization of a Threonine-Rich Cluster in Hepatitis C Virus Nonstructural Protein 5A and Its Contribution to Hyperphosphorylation
... were replication deficient (39), we transiently expressed NS3-5B JFH-1 under transcriptional control of the T7 promoter in Huh7-Lunet cells constitutively expressing T7 RNA ... See full document
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Genetic Complementation of Hepatitis C Virus Nonstructural Protein Functions Associated with Replication Exhibits Requirements That Differ from Those for Virion Assembly
... helper virus; the authors of this report also com- mented on their inability to achieve trans-complementation by expressing NS5A ...Our complementation results on virion assembly were ... See full document
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Interferon Resistance of Hepatitis C Virus Genotype 1b: Relationship to Nonstructural 5A Gene Quasispecies Mutations
... the nonstructural 5A (NS5A) protein of hepatitis C virus genotype 1b (HCV-1b) was recently suggested to be the interferon sensitivity-determining region (ISDR), because HCV-1b ... See full document
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A Conserved Tandem Cyclophilin-Binding Site in Hepatitis C Virus Nonstructural Protein 5A Regulates Alisporivir Susceptibility
... a protein hav- ing IDP domains ...for protein-protein interac- tion ...HCV replication complex such as NS5B and NS3 ...HCV replication complex (34); pre- liminary data, however, ... See full document
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Hepatitis C Virus Nonstructural Protein 5B Is Involved in Virus Morphogenesis
... alter RNA replication. The rescue of nonviable chimeric genomes by single point mutations in NS2 and NS5B could be due to the enhancement of viral RNA ...viral RNA replication, ... See full document
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The C-Terminal α-Helix Domain of Apolipoprotein E Is Required for Interaction with Nonstructural Protein 5A and Assembly of Hepatitis C Virus
... HCV replication were determined by measuring the levels of HCV proteins in the transfected and HCV-infected ...HCV replication, as similar levels of NS5A protein ...HCV RNA (data not shown) ... See full document
10
De Novo Initiation of RNA Synthesis by Hepatitis C Virus Nonstructural Protein 5B Polymerase
... novo RNA synthesis using chemically synthesized small RNA as ...novo RNA synthesis, small RNAs (21 or 22 nt) representing the 3⬘-terminal sequence of HCV positive-strand RNA were chemically ... See full document
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Nonstructural 5A Protein of Hepatitis C Virus Regulates Soluble Resistance-Related Calcium-Binding Protein Activity for Viral Propagation
... epatitis C virus (HCV) is a major causative agent of non-A, non-B ...enveloped virus with a positive-sense, single-stranded RNA genome of ⬃ ...and nonstructural (p7 and NS2 to NS5B) ... See full document
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Mutational Analysis of Hepatitis C Virus Nonstructural Protein 5A: Potential Role of Differential Phosphorylation in RNA Replication and Identification of a Genetically Flexible Domain
... Nonstructural protein 5A of the hepatitis C virus (HCV) is a highly phosphorylated molecule implicated in multiple interactions with the host cell and most likely involved in ... See full document
8
Regulation of Hepatitis C Virus Replication by Nuclear Translocation of Nonstructural 5A Protein and Transcriptional Activation of Host Genes
... Hepatitis C virus (HCV) nonstructural protein 5A (NS5A) is involved in regulating viral replication through its direct interac- tion with the HCV RNA-dependent ... See full document
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Interaction between Nonstructural Proteins NS4B and NS5A Is Essential for Proper NS5A Localization and Hepatitis C Virus RNA Replication
... HCV nonstructural pro- teins accumulate, including NS5A (30, ...lethal replication phenotype of the NS5A helix double mutant is restored by an NS4B carboxyl-terminal suppres- sor mutation, we were curious ... See full document
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Nonstructural Protein 5A (NS5A) and Human Replication Protein A Increase the Processivity of Hepatitis C Virus NS5B Polymerase Activity In Vitro
... The protein prep- arations were visualized by SDS-PAGE ...both RNA and DNA templates (40–46). The NS3 helicase can unwind RNA/RNA, RNA/DNA, and DNA/DNA substrates in a 3=-to-5= ... See full document
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Role for TBC1D20 and Rab1 in Hepatitis C Virus Replication via Interaction with Lipid Droplet-Bound Nonstructural Protein 5A
... with hepatitis C vi- rus ...chronic hepatitis, which may progress to life-threatening liver cirrhosis and hepatocellular carcinoma ...strand RNA virus containing a ...as ... See full document
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