[PDF] Top 20 Endpoints In Intensive Care Unit Based Randomized Clinical Trials

... industry-sponsored trials, may be less likely to be submitted for publication or ultimately be accepted for ...nonmortal clinical endpoints ... See full document

... included trials, possibly due to the fact that the different PCT guidance strategies (including antibiotic initiation, discontinuation, or combination of antibiotic initiation and discontinuation strategies) had ... See full document

... ICU: intensive care unit; ITT: intention to treat; LCT: long-chain triglycerides; LOS: length of stay; MD: mean difference; MV: mechanical ventilation; NG: nasogastric; NR: non-reported; OR: odds ... See full document

... There are unique challenges and safety concerns when considering early mobilization of critically ill patients in the ICU. However, existing data demonstrate that mobilization, including ambulation, of mechanically ... See full document

... searched. Randomized controlled trials (RCTs) conduct- ed in critically ill patients that compared the early enteral nutrition (EEN), provided within 48 h of intensive care unit (ICU) ... See full document

... were randomized controlled trials, could not confirm such a role for corticosteroids [10, 13, 14, 18, 39, 40, 42–44, 46, 49] or for neuromuscular blocking agents [14, ... See full document

... not randomized, and the controls were case-matched using a controversial propensity ...controlled trials including 1610 patients, a signifi- cant reduction in morbidity was shown when a PAC-guided ... See full document

... The rationale for airway hygiene is the prevention of pneumonia and respiratory failure. Current practice reflects clinical experience and expert opinion and not the results of controlled clinical ... See full document

... We began this process by pairing each of the eight categories with a proposed endpoint. It was important that longitudinal data regarding the proposed endpoint would be obtainable within a large pragmatic RCT and, if the ... See full document

... Early diagnosis combined with initiation of appropriate antibiotic treatment remains the cornerstone of sepsis care [30]. Once treatment is initiated, close monitoring of patients is of the utmost importance to ... See full document

... Singer, Taylor, LeBlanc, Williams, and Thode Jr (2014) examined the impact emergency department point-of-care (POC) lactate measurements in sepsis patients had on mortality and time to intravenous fluids. The ... See full document

... previous randomized controlled trial reported that dexmedetomidine was associated with a reduced mortality rate among patients with sepsis ...recent randomized controlled trial that en- rolled mechanically ... See full document

... This retrospective observational study is subject to the usual limitations of such analyses. Some events may not have been reported by the remote hospitals, and the reporting of complications was limited to pa- tients ... See full document

... Association between malnutrition and clinical outcomes in the intensive care unit: A 316. systematic review[r] ... See full document

... may care for patients in both groups and there- fore may change behavior based on exposure to the study ...come. Based on our previous experience with e- CHAMP and that of other delirium ... See full document

... Results: A total of 29,499 patients were enrolled fi nally, among which 3,332 patients (11.30%) were comorbid with COPD. A higher 28-day mortality was observed among patients with COPD than those without COPD (13.90% ... See full document

... Person-centered care is commonly associated with a form of experiential qualitative medical knowledge rooted in clinical experience and worked out in everyday clinical practice, whereas ... See full document

... In a 38-centre imaging continuation of a therapeutic trial of milameline [3], the estimated number of subjects per arm required to detect a 50% reduction in the rate of decline over 1 year was only 21 for hippocampal ... See full document

... secondary endpoints, and eligibility requirements among other in- formation to be submitted for each registered trial ...For clinical trials registered in ...the trials included in our study ... See full document

... Although the febrile response has existed for millions of years, controlled studies evaluating the benefits of fever do not exist. Most of the studies in humans evaluating clinical outcomes, fever and infection ... See full document