[PDF] Top 20 Epstein-Barr virus types 1 and 2 differ in their EBNA-3A, EBNA-3B, and EBNA-3C genes.
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Epstein-Barr virus types 1 and 2 differ in their EBNA-3A, EBNA-3B, and EBNA-3C genes.
... We determined the DNA sequence of the AG876 EBV-2 EBNA-3 coding region and have compared it with known B95-8 EBV-1 EBNA-3 sequences to delineate the extent of divergence between EBV-1 an[r] ... See full document
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Epstein-Barr Virus EBNA-3C Is Targeted to and Regulates Expression from the Bidirectional LMP-1/2B Promoter
... that EBNA-3C regulates the transcription of these two distinct latency-associated ...that EBNA-3C is associated with the LMP-1/2B bidi- rectional promoter when LMP-1 and LMP-2B ... See full document
9
A Genome-Wide Epstein-Barr Virus Polyadenylation Map and Its Antisense RNA to EBNA
... polyadenylated EBNA-antisense transcripts, some of which the existence was sug- gested previously by microarray, RNA-seq, and PacBio Iso-seq analyses of the EBV transcriptome (36, 76, ...that EBNA-antisense ... See full document
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EBNA-3B- and EBNA-3C-Regulated Cellular Genes in Epstein-Barr Virus-Immortalized Lymphoblastoid Cell Lines
... with virus derived from an EBNA-3B-deleted BAC mutant containing a kanamycin resistance cassette grow slowly and are hypomorphic for EBNA-3C ...the EBNA-3B ORF from an EBV ... See full document
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Interferon-independent and -induced regulation of Epstein-Barr virus EBNA-1 gene transcription in Burkitt lymphoma.
... Epstein-Barr virus (EBV) establishes a latent infection of B lymphocytes that is sustained for the life of its human ...of EBNA-1, the established latency-associated proteins are known ... See full document
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Identification of Major Phosphorylation Sites of Epstein-Barr Virus Nuclear Antigen Leader Protein (EBNA-LP): Ability of EBNA-LP To Induce Latent Membrane Protein 1 Cooperatively with EBNA-2 Is Regulated by Phosphorylation
... Epstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is frequently associated with a variety of neoplastic dis- eases, including endemic Burkitt’s lymphoma, nasopharyngeal carcinoma, ... See full document
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Downregulation of Integrin Receptor-Signaling Genes by Epstein-Barr Virus EBNA 3C via Promoter-Proximal and -Distal Binding Elements
... EBNA 3C and EBNA 3B positively regulate CCL3 in the EBV- negative BL cell line BL31 (52) (Table ...that EBNA 3A may repress CCL3 and CCL4 expression ...of EBNA 3A ... See full document
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Epstein-Barr Virus Nuclear Antigen 3C Putative Repression Domain Mediates Coactivation of the LMP1 Promoter with EBNA-2
... The Epstein-Barr virus (EBV) nuclear antigen 3C (EBNA-3C) regulates virus and cell genes and is essential for EBV-mediated transformation of primary B ... See full document
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Interaction of Epstein-Barr Virus Nuclear Antigen Leader Protein (EBNA-LP) with HS1-Associated Protein X-1: Implication of Cytoplasmic Function of EBNA-LP
... Epstein-Barr virus (EBV) is a ubiquitous human herpesvi- rus, closely associated with a variety of neoplastic diseases, including endemic Burkitt’s lymphoma, nasopharyngeal carci- noma, Hodgkin’s ... See full document
8
Multiple Functions within the Epstein-Barr Virus EBNA-3A Protein
... the EBNA-3A protein of Epstein-Barr virus were shown to be capable of binding to the cell protein RBP-Jk (also known as CBF-1), a component of the Notch signaling ...binding, ... See full document
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EBNA-2 and EBNA-3C extensively and mutually exclusively associate with RBPJkappa in Epstein-Barr virus-transformed B lymphocytes.
... the EBNA proteins (32) revealed an absence of EBNA-1 in the RBPJ k immunoprecipitate ...of EBNA-1 was a consistent result with immu- noblots of every RBPJk ...of EBNA-3C ... See full document
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5-Azacytidine up regulates the expression of Epstein-Barr virus nuclear antigen 2 (EBNA-2) through EBNA-6 and latent membrane protein in the Burkitt's lymphoma line rael.
... American Society for Microbiology 5-Azacytidine Up Regulates the Expression of Epstein-Barr Virus Nuclear Antigen 2 EBNA-2 through EBNA-6 and Latent Membrane Protein in the Burkitt's Lym[r] ... See full document
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Epstein-Barr virus nuclear protein LP stimulates EBNA-2 acidic domain-mediated transcriptional activation.
... that EBNA-LP stimulates EBNA-2 activation of the LMP1 promoter and of the LMP1/LMP2B bidirectional transcriptional regulatory ...element. EBNA-LP alone has only a negative effect. ... See full document
8
oriP is essential for EBNA gene promoter activity in Epstein-Barr virus-immortalized lymphoblastoid cell lines.
... During Epstein-Barr virus latent infection of B lymphocytes in vitro, six viral nuclear antigens (EBNAs) are expressed from one of two promoters, Cp or Wp, whose activities are mutually ...the ... See full document
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Direct and Indirect Regulation of Cytokine and Cell Cycle Proteins by EBNA-2 during Epstein-Barr Virus Infection
... of EBNA-LP, we detected the viral protein in only about 25% of B cells, but Western blot analysis indicated that more p27 was lost than could be accounted for by infection of this proportion of the B-cell ... See full document
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EBNA-2 of herpesvirus papio diverges significantly from the type A and type B EBNA-2 proteins of Epstein-Barr virus but retains an efficient transactivation domain with a conserved hydrophobic motif.
... 2990-3003 0022-538X/93/062990-14$02.00/0 Copyright © 1993, American Society for MicrobiologY EBNA-2 of Herpesvirus Papio Diverges Significantly from the Type A and Type B EBNA-2 Proteins[r] ... See full document
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Influence of the Epstein-Barr virus nuclear antigen EBNA 2 on the growth phenotype of virus-transformed B cells.
... Finally, it is interesting to note that the growth rate and saturation densities of the BL cell lines listed in Table 1, and serving as a source of transforming virus for the present exp[r] ... See full document
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The Epstein-Barr virus EBNA-2 gene in oral hairy leukoplakia: strain variation, genetic recombination, and transcriptional expression.
... To verify that the variation among the HLP EBNA-2 clones represented the in vivo DNA structure of EBNA-2 rather than in vitro recombination during the PCR and cloning processes, EBNA-2A [r] ... See full document
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Second-site homologous recombination in Epstein-Barr virus: insertion of type 1 EBNA 3 genes in place of type 2 has no effect on in vitro infection.
... Since the parental P3HR-1 genome is type 2 and the transfected type 1 Sall C fragment is approximately 10% divergent in nucleotide sequence within the EBNA 3 genes, recombination at thes[r] ... See full document
10
Interaction of the lymphocyte-derived Epstein-Barr virus nuclear antigen EBNA-1 with its DNA-binding sites.
... DNA filter binding assays and DNase I footprinting experiments showed that the intact Raji EBNA-1 protein recognized the two binding site loci in oriP and the BamHI-Q locus and no other [r] ... See full document
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