[PDF] Top 20 THE EVOLUTION OF SELECTIVE ADVANTAGE IN A DELETERIOUS MUTATION
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THE EVOLUTION OF SELECTIVE ADVANTAGE IN A DELETERIOUS MUTATION
... If the standard deviation due to additive genetic effects is equal to the initial difference between the wild type and the mutant heterozygote, about 48,000 generations are needed w[r] ... See full document
6
Selective-Advantage Profile of Human Immunodeficiency Virus Type 1 Integrase Mutants Explains In Vivo Evolution of Raltegravir Resistance Genotypes
... started evolution of resistance following the N155 pathway are almost always outcompeted by variants ex- pressing the Q148 ...the selective advantage of viral mutants across a wide range of ... See full document
5
The Effects of Deleterious Mutations on Evolution at Linked Sites
... of evolution at a given site in the genome can be influenced by the action of selection at other sites, especially when these are closely linked to ...particular, deleterious variants are continually being ... See full document
18
The evolution of recombination rates caused by recurrent deleterious mutations
... the evolution of recombination rates caused by synergistic fitness interactions between recurrent deleterious ...of deleterious mutations are significantly ...high mutation rates, but that ... See full document
120
Limited Dispersal, Deleterious Mutations and the Evolution of Sex
... if there is one-way mutation to deleterious alleles, and if there is no movement of genetic material between sites as a result of colonization, migration or sexual [r] ... See full document
8
Selective Sweeps and Parallel Pathoadaptation Drive Pseudomonas aeruginosa Evolution in the Cystic Fibrosis Lung
... causative mutation due to the very low rate of recombination. Incomplete selective sweeps, such as those we observe in clade B, have been documented in other systems and generated substan- tial experimental ... See full document
14
The Evolution of Mutator Genes in Bacterial Populations: The Roles of Environmental Change and Timing
... with mutation rate, this increase slows down due the conditions specified in the model for the ascent of to clonal ...result, mutation rates are not mutator ...the selective advantage predict ... See full document
12
Fixation of a deleterious allele under mutation pressure and finite selection intensity.
... and selective forces until it takes over the entire population, and is a key topic in population ...a deleterious allele has been shown to be important to shed light on the evolutionary dynamics of related ... See full document
27
Joint Evolution of Dispersal and Inbreeding Load
... mildly deleterious mutations (s ¼ ...the evolution of dispersal in populations of 10 demes with and without inbreeding load for three demic sizes N ¼ 10, 50, and ...genomic mutation rate U ¼ 1 for ... See full document
13
Inferring deleterious-mutation parameters in natural daphnia populations
... genomic mutation rate to mildly deleterious alleles (U) are crucial to testing theories for the evolution of sex (3-6), mate choice (5, 7, 8), outbreeding mechanisms (7), diploidy (9), and the ... See full document
9
Nature of Deleterious Mutation Load in Drosophila
... Much population genetics and evolution theory depends on knowledge of genomic mutation rates and distributions of mutation effects for fitness, but most information comes[r] ... See full document
7
The Influence of Hitchhiking and Deleterious Mutation Upon Asexual Mutation Rates
... on mutation rate with only two populations suggests that a variety of interesting phenomena may appear in such ...the evolution of mutation rates in such ... See full document
12
Terumi Mukai and the Riddle of Deleterious Mutation Rates
... further evolution” (Haldane 1937, ...the mutation rate in a random sample of and effects of deleterious ...of deleterious muta- ...lethal mutation rates; average rates from an interest ... See full document
9
Stressful environments can indirectly select for increased longevity.
... a mutation which increases life span and stress resistance in ...a selective advantage when fluctuations in the environment include states that are ... See full document
11
Limits to Adaptation in Partially Selfing Species
... as deleterious al- leles, evidence exists that they arise frequently enough to affect local adaptation and domestication in self-fertilizing ...linked deleterious mutation on a selective ...fix ... See full document
37
Protecting exons from deleterious R-loops: a potential advantage of having introns
... and evolution of ...the evolution of ...transcriptional deleterious R- loops by introns", last paragraph), the statement: "At least the translated regions of most mature mRNAs are unlikely to ... See full document
9
Inbreeding Depression and Inferred Deleterious-Mutation Parameters in Daphnia
... (1996a) original procedure. Without the requirement of obtaining multiple selfed genotypes from each out- crossed parent, estimation of total genetic variance in the selfed g[r] ... See full document
9
Estimation of Deleterious Genomic Mutation Parameters in Natural Populations by Accounting for Variable Mutation Effects Across Loci
... of deleterious genomic mutations ...variable mutation effects across loci. Under variable mutation effects, the mean fitness and genetic variance for fitness of parental and progeny generations ... See full document
14
Substitution processes in molecular evolution. III. Deleterious alleles.
... If the house-ofcards model is to be a model of mo- lecular evolution where the vast majority of substitutions are deleterious, then 2, must decrease in value much m[r] ... See full document
10
Adapt Globally, Act Locally: The Effect of Selective Sweeps on Bacterial Sequence Diversity
... adaptive mutation confers more familiar and culturable taxa, bacterial systematists a benefit only in the genetic background of its original have found an empirical correspondence between eco- population, and (2) ... See full document
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