[PDF] Top 20 Exploring the pre-immune landscape of antigen-specific T cells
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Exploring the pre-immune landscape of antigen-specific T cells
... with specific TCRs (according to epitope restrictions from ...rearrangements specific for epitopes restricted by a given HLA and the expected number of TCR rearrangements, computed with the assumption of ... See full document
14
Single-cell multiplexed cytokine profiling of CD19 CAR-T cells reveals a diverse landscape of polyfunctional antigen-specific response
... single cells residing in a nanowell, representing a more physiological environment than any other available single cell ...single cells for time-point study can be measured by ana- lyzing a serial of ... See full document
16
Original Article Therapeutic and anti-metastatic effect of CIKs on cervical cancer enhanced by modified HPV16 E7-pulsed DCs with SOCS1-knockdown
... professional antigen- presenting cells (APC) are considered at the centre of the immune system because of their ability to regulate both immune tolerance and ...(mature), antigen-loaded ... See full document
10
A variant of SCID with specific immune responses and predominance of γδ T cells
... produced specific antibodies despite minimal B cell numbers. Memory B cells were detected and antibodies were produced not only against some vaccines and infections, but also against ...oligoclonal T ... See full document
10
T cells expressing chimeric antigen receptor promote immune tolerance
... target cells justifies use of stably transduced CAR T ...in antigen-specific peripheral tolerance, as MHC-matched second- ary skin grafts were accepted, while “third-party” grafts were ... See full document
18
Dysregulation of Circular Antigen Specific T Cells Anergy in Autoimmune Vitiligo
... totoxic T cell (CTL) proliferation was significantly decreased after cultivation with Tregs from healthy individuals (p < ...circulating cells of vitiligo patients compared with healthy ...that T ... See full document
7
CD8 T Cells in Innate Immune Responses: Using STAT4 Dependent but Antigen Independent Pathways to Gamma Interferon during Viral Infection
... and antigen stimulation in acutely responding and resulting memory CD8 T ...CD8 T cells acquired a sensitivity to IL-12, the type 1 IFN IFN-␣, and IL-18 stimulation for IFN- ␥ and CD25 ... See full document
14
Molecular mechanisms of T cells activation by dendritic cells in autoimmune diseases
... between T cell and dendritic cells (DCs) that leads to T cell activation affects the progression of the immune response including autoimmune ...diseases. Antigen presentation on ... See full document
10
Alloantigen specific regulatory T cells generated with a chimeric antigen receptor
... disease-relevant antigen-specific Tregs may have numerous advantages, such as a need for fewer cells and reduced risk of nonspecific immune ...allogeneic antigen-presenting ... See full document
13
Glatiramer acetate (Copaxone®) induces degenerate, Th2 polarized immune responses in patients with multiple sclerosis
... on antigen-specific T-cell responses in patients with multiple sclerosis ...universal antigen, inducing proliferation, independent of any prior exposure to the polymer, in T-cell lines ... See full document
11
Achieving antigen specific immune regulation
... somatic cells, cause a variety of diseases that primarily affect striated muscle, adipocytes, or peripheral nerves or cause fea- tures of premature ...stressed cells first develop chromatin and nuclear ... See full document
5
Clonal analysis of CD4+ T cells
... entire immune response is unclear. In an immune response activation o f T cells occurs in lymphoid organs including the lymph nodes, spleen and mucosal associated lymphoid tissue, where ... See full document
243
Increased Expression of the NK Cell Receptor KLRG1 by Virus-Specific CD8 T Cells during Persistent Antigen Stimulation
... by specific antibody ...⫹ T cells in the peripheral blood were stained with tetramers, and as previously reported, the major- ity of these cells expressed KLRG1 ...⫹ T cells not ... See full document
5
Sensitizing antigen specific CD8+ T cells for accelerated suicide causes immune incompetence
... sensitizes cells specifically to death receptor–mediated apoptosis but not to other mechanisms of apoptosis induction — for example, DNA damage — or glucocorticoid- induced cell death ...autoreactive T and ... See full document
10
Cancer biomarkers for targeted therapy
... bispecific T cell engagers, and antibody-drug ...maturation antigen, and CD138 are targets for cancer immunotherapeutic agents, including the chimeric antigen receptor - engineered T ... See full document
7
In vivo imaging of the immune response upon systemic RNA cancer vaccination by FDG-PET
... programmed immune in- ...the immune system and the temporal relation- ship of the processes is important for further optimizing such ...necessary immune adjuvants, the timing of re-stimulation, and ... See full document
10
Engineering switchable and programmable universal CARs for CAR T therapy
... chimeric antigen receptor (CAR) has a fixed design, and one type of CAR T cells can only target one antigen ...the antigen recognition domain is split from the signaling domain of a ... See full document
9
The roles of stem cell memory T cells in hematological malignancies
... + T cells expressing Sca-1 (stem cell antigen 1), CD122, and ...of T cells was able to generate and sustain all allogeneic T cell sub- sets in GVHD ...+ T cells ... See full document
5
CD4+ T cells specific to a glomerular basement membrane antigen mediate glomerulonephritis
... B cells are involved in GN pathogenesis in our passive-transfer ...B cells might be involved in several ways. First, antigen-specif- ic B cells may produce anti-GBM Ab, which in turn causes ... See full document
9
Induction of antigen specific human cytotoxic T cells by Toxoplasma gondii
... of T cells in immunity to the parasite Toxoplasma gondii, antigen-specific T cell clones were generated using peripheral blood mononuclear cells from seropositive ...of ... See full document
9
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