[PDF] Top 20 Expression and function of the insulin receptor substrate proteins in cancer
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Expression and function of the insulin receptor substrate proteins in cancer
... with cancer progression include elevated free fatty acids, obesity and oxidative stress ...IRS function include many kinases that are activated by onco- genic signaling, including mTor, Akt, multiple PKC ... See full document
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<p>Expression and biological function of rhotekin in gastric cancer through regulating p53 pathway</p>
... high expression level in GC compared with normal tissues. RTKN expression strongly associated with tumor size, TNM stage, lymphnode metastasis and the poor prognosis of patients with ...RTKN ... See full document
12
Expression of transmembrane protein 26 (TMEM26) in breast cancer and its association with drug response
... The negative effect of siTM on integrin β1 expression may suggest that TMEM26 modulates integrin β1 function. To explore this possibility, we performed spheroid formation assays. This assay was chosen ... See full document
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Expression of Chemokine Receptor CXCR4 in Primary and Metastatic Neuroblastoma Expression of CXCR4 in Neuroblastoma
... organ function and therefore causes ...Once cancer has disseminated from the primary tumor, chemotherapy is the most widely used treatment modality as localized therapies (surgery and radiation) are often ... See full document
7
Insulin receptor substrate 1 is a substrate of the Pim protein kinases
... vivo substrate for Pim protein kinases, MEF cells derived from wild type (WT) and triple knockout of Pim1, Pim2 and Pim3 (TKO) FVB mice were ...protein expression was undetectable in TKO cells when protein ... See full document
14
Lack of interaction between ErbB2 and insulin receptor substrate signaling in breast cancer
... The IGF and ErbB pathways are involved in tumor initi- ation, tumor progression and resistance to therapy [22–25]. These pathways overlap in their signal transduction path- ways, sharing PI3K/Akt and MEK/ERK signaling, ... See full document
7
Mosaic analysis of insulin receptor function
... different insulin responses display different sensitivities to activation of insulin ...of insulin action (i.e., insulin resistance) predis- pose to type 2 diabetes, many of the complications ... See full document
12
Hippo mediated suppression of IRS2/AKT signaling prevents hepatic steatosis and liver cancer
... liver cancer via activation of AKT or the transcriptional regulators YAP/TAZ, respectively; however, the potential for crosstalk between the PTEN/AKT and Hippo/YAP/TAZ pathways in liver tumorigenesis has thus far ... See full document
17
Insulin receptor substrate signaling suppresses neonatal autophagy in the heart
... in insulin signaling that was offset by a modest induction in IGF-1R expression in CIRKO hearts, which retain the ability to respond to insulin (11, ...of insulin and IGF-1Rs in cardiac and ... See full document
16
erbB3 recruitment of insulin receptor substrate 1 modulates insulin like growth factor receptor signalling in oestrogen receptor positive breast cancer cell lines
... [41]. Expression of phos- phorylated membrane and cytoplasmic IRS-1 Y612 has previously been verified by immunocytochemistry in ER+ breast cancer cell lines ... See full document
17
Understanding the mechanisms of aromatase inhibitor resistance
... its substrate and inhibitors ...breast cancer patients, reported that two tightly linked SNPs (rs6493497 and rs7176005) were signi fi cantly associated with a greater change in aroma- tase activity after AI ... See full document
11
Altered function of insulin receptor substrate 1–deficient mouse islets and cultured β cell lines
... peripheral insulin resistance followed by a failure of compensation by the pancreatic β cell and, ultimately, frank hyperglycemia (21, ...the insulin-signaling cascade may play an important role in the ... See full document
8
The insulin receptor substrate Chico regulates antibacterial immune function in Drosophila
... To understand the reduced growth of P. luminescens and E. coli in chico mutant flies, we first estimated the activation of the NF-κB signaling pathways Imd and Toll that regulate the expression of AMP genes in D. ... See full document
11
<p>Variants in the Upstream Region of the Insulin Receptor Substrate-1 Gene Is Associated with Major Depressive Disorder in the Han Chinese Population</p>
... Insulin receptor substrate (IRS) docking proteins are the key downstream signaling molecules in the insulin receptor (IR) signaling ...and function. Recent evidence ... See full document
7
Tumor necrosis factor alpha and hyperglycemia induced insulin resistance Evidence for different mechanisms and different effects on insulin signaling
... of insulin secretion and by insulin resistance of the major target tissues ...particular, insulin resistance of the skeletal muscle appears to play a pivotal role in the pathogenesis of the disease ... See full document
8
The role of insulin receptor substrate 2 in hypothalamic and β cell function
... melanocortin function, and in RIPCreIrs2KO and NesCreIrs2KO mice, we detected reduced hypothalamic POMC ...leptin receptor in POMC neurons generates mice that have some phenotypic features in common with ... See full document
12
Acetylation of insulin receptor substrate-1 is permissive for tyrosine phosphorylation
... Multiple histone acetyltransferases (HATs) and histone deacetylases (HDACs) control the state of histone acetyla- tion and hence play a regulatory role in modulating the structure and function of chromatin [25]. ... See full document
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PubMedCentral-PMC4798554.pdf
... I insulin-like growth factor receptor (IGF-1R) have not been developed with predictive biomarkers to identify tumors with receptor ...the insulin receptor substrate (IRS) adaptor ... See full document
12
Regulation of insulin receptor substrate 1 in liver and muscle of animal models of insulin resistance
... in insulin binding and a parallel increase in insulin-stimulated receptor phosphorylation in muscle of fasting and streptozotocin-induced (STZ) diabetic ...overall receptor phosphorylation in ... See full document
12
cncRNAs : Bi functional RNAs with protein coding and non coding functions
... the expression of ptsG mRNA by base ...gene expression. SRA, the RNA co-regulator is thought to function as a scaffold and brings the whole complex together at the nuclear response element (NRE) and ... See full document
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