[PDF] Top 20 Expression of the immune regulation antigen CD70 in osteosarcoma

... Established osteosarcoma cell lines HOS, HOS-143b, OHS, OSA (SJSA-1), SAOS-2, U2-OS, ZK-58; and Ewing sarcoma cell lines A673, CADO-ES, ET10, EW3, IOR/BER, RD-ES, SK-ES-1, SK-N-MC, STA-ET1, ...other ... See full document

... gene expression of osteosarcoma datasets were downloaded from the GEO data repository (http:// ...average expression value of gene measured by multiple probes was calculated as the final ... See full document

... Differential expression of ING4 between osteosarcoma tissues and paired normal tissues was evaluated by paired sample t ...protein expression and the clinicopathological charac- ... See full document

... phosphatase, expression of an NTPPPH gene can be shared by cells from bone, cartilage, and liver and by certain ...U20S osteosarcoma cells, articular chondrocytes, homogenized human knee cartilages, human ... See full document

... In osteosarcoma, aber- rant expression of several miRs and their functions have been ...decreased expression in osteosarcoma tissues, and its downregula- tion was correlated with advanced ... See full document

... in osteosarcoma using mRNA array and found that CRYAB was a candidate ...CRYAB expression and bound the promoter of ...the expression level of CRYAB was increased in osteosarcoma tissues and ... See full document

... peroxidase, and then soaked in citrate buffer (pH = 6.0) for 10 minutes for antigen retrieval. Unspecific binding was blocked by 5% bovine serum albumin, after which the speci- mens were incubated in primary ... See full document

... Nude mice (four weeks old) were purchased from Model Animal Research Center of Nanjing University (Nanjing, Jiangsu, China). The animals were housed under standard conditions (24°C± 2°C, 20 relative humidity, 12 hr ... See full document

... the expression of MCL1 (myeloid cell leukemia sequence 1), MMP2 (encoding matrix metallo- proteinase 2), VEGFA (vascular endothelial growth factor A) and ITGB1 (integrin β1) genes by directly binding to their ... See full document

... The OS time in the low-expression group was significantly shorter than that in the high- expression group. The median survival of HES1- low group was 54±1.3 months, while that of HES1-high group was 70±1.5 ... See full document

... the immune system has been initially identi ed in RANKL knockout mice in which the development of secondary lymphoid organs was impaired especially the lymph nodes but also at the central level where the ... See full document

... Numbl expression in OS samples and con- firmed that Numbl is down-regulated in ...reduced expression of Numbl was closely associated with the OS ...Numbl expression level was a predictor of poor ... See full document

... ligand CD70, CD27 signalling enhances T- cell proliferation and differentiation to effector and memory T cells and therefore has potential as an immune modulatory target in cancer ...targeting immune ... See full document

... on regulation of peripheral T cell responses One possible explanation for the occur- rence of autoimmune responses is that the T cell repertoire of patients with dia- betes includes autoreactive clones that have ... See full document

... CD40L, CD70, and CD14a com- pared with the healthy persons [23, ...of antigen-presenting cells including B lymphocytes, macrophages, and dendritic cells [25], while CD70 (the ligand for CD27) that ... See full document

... of antigen-specific T cell responses during primary acute re- ...Constitutive expression of CD70 on T cells induces a T cell differentiation pathway that is similar to that observed during chronic ... See full document

... in immune responses including antigen processing and presentation of peptide antigen via MHC class I were over-presented among the up- regulated genes (Additional file 7: Figure ...positive ... See full document

... Consequently, expression of its ligand, CD70, is tightly regulated and only transiently expressed on activated T cells, B cells and mature dendritic cells ...constitutive CD70 expression in ... See full document

... the expression of exosomal miRNAs is different to that of serum circulating miRNAs [75] and protein, as well as that of protein miRNAs ...the expression of these miRNAs, the exosomal content of cells can be ... See full document

... different immune system cell types: macrophages and B cells, respectively, which significantly differ in their functional ...proHB-EGF expression was low. The main tasks of B cells are recognition of ... See full document