[PDF] Top 20 Gene expression during reactivation of herpes simplex virus type 1 from latency in the peripheral nervous system is different from that during lytic infection of tissue cultures.
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Gene expression during reactivation of herpes simplex virus type 1 from latency in the peripheral nervous system is different from that during lytic infection of tissue cultures.
... (Fig. 1). Oct-1 was shown to rise by 1 h ...findings from in situ hybridization studies using both latently infected and uninfected TG ...(Fig. 1 and ...cause reactivation. ... See full document
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Herpes Simplex Virus type 1 lytic viral gene expression during the establishment and maintenance of latency
... Herpes Simplex Virus (HSV) type I causes cold sores but is also associated with severe outcomes such as encephalitis and ...primary lytic HSV-1 infection in the skin and ... See full document
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Herpes Simplex Virus DNA Synthesis Is Not a Decisive Regulatory Event in the Initiation of Lytic Viral Protein Expression in Neurons In Vivo during Primary Infection or Reactivation from Latency
... HSV lytic cycle in the nervous system (9, ...E gene expression is activated by viral DNA synthesis in ...Wild-type virus can replicate in both compartments, and a positive ... See full document
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Herpes Simplex Virus Type 1 Promoter Activity during Latency Establishment, Maintenance, and Reactivation in Primary Dorsal Root Neurons In Vitro
... culture system has been utilized to study herpes simplex virus (HSV) latency establishment, maintenance, and ...viral gene expression in neurons following infection ... See full document
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Utilization of the herpes simplex virus type 1 latency-associated regulatory region to drive stable reporter gene expression in the nervous system.
... HSV type 1 (HSV-1) recombinants containing reporter gene constructs inserted downstream of all currently recognized LAT regulatory sequence ...encephalomyocarditis virus (EMCV) internal ... See full document
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Evidence that the Herpes Simplex Virus Type 1 ICP0 Protein Does Not Initiate Reactivation from Latency In Vivo
... the expression of the herpes simplex virus lytic cycle from the latent viral genome are not ...on reactivation, ...the lytic cycle and analysis of the promoter(s) ... See full document
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Gamma Interferon Can Block Herpes Simplex Virus Type 1 Reactivation from Latency, Even in the Presence of Late Gene Expression
... viral gene expression in latently infected ...(TG) during primary HSV-1 infec- tion and remain in close apposition to infected neurons for prolonged periods after latency is uniformly ... See full document
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Herpes Simplex Virus 1 Infection of Tree Shrews Differs from That of Mice in the Severity of Acute Infection and Viral Transcription in the Peripheral Nervous System
... early gene, its protein product is a promiscuous activator of both cell and virus gene ...efficient lytic in- fection and reactivation from latency ...ICP0 ... See full document
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Gene Array Analysis Reveals Changes in Peripheral Nervous System Gene Expression following Stimuli That Result in Reactivation of Latent Herpes Simplex Virus Type 1: Induction of Transcription Factor Bcl-3
... During latency, the viral genome is packaged in a compact chromatin structure which is likely to be refractory to replica- tion and transcription (15, 47, ...comes from the study of VP16 ...possible ... See full document
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ICP0 Is Required for Efficient Reactivation of Herpes Simplex Virus Type 1 from Neuronal Latency
... HSV-1 reactivation pro- cess? Latency in the herpesvirus field has long been defined as the absence of infectious virus in cells or tissues that contain viral genomes, whereas ... See full document
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Gamma interferon expression during acute and latent nervous system infection by herpes simplex virus type 1.
... HSV infection can- not be excluded, our working hypothesis is that the persistence of these T cells and the sustained expression of IFN- g occur in response to HSV ...antigen. During latency, ... See full document
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Genetic Studies Exposing the Splicing Events Involved in Herpes Simplex Virus Type 1 Latency-Associated Transcript Production during Lytic and Latent Infection
... protection experiments using a 39 end-labeled probe centered over the outer splice acceptor signal (Fig. 6A), we mapped the 39 end of the 2-kb LAT expressed in SK-N-SH cells infected with wt strain 17 to a position ... See full document
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Extracellular vesicles during Herpes Simplex Virus type 1 infection: an inquire
... the type of recipient cells deter- mine their function [4, 5, ...influence gene expression [25, ...of gene expression in recipient ...mainly from endo- somes, the plasma membrane ... See full document
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Linker Histones Are Mobilized during Infection with Herpes Simplex Virus Type 1
... infected with 30 PFU/cell of KM110 at 4 or 7 hpi, respectively (Table 5; Fig. 6, KM110 Vero), regardless of whether they expressed GFP-H1.2 or not. In the cells in which it was de- tected, ICP4 was mainly nuclear ... See full document
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Efficient Reactivation of Latent Herpes Simplex Virus from Mouse Central Nervous System Tissues
... efficient reactivation of latent HSV from ganglia but not from the CNS ...viral reactivation from mouse CNS by affecting the survival of fragile brain ...removed from 10-week-old ... See full document
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A Novel Selective LSD1/KDM1A Inhibitor Epigenetically Blocks Herpes Simplex Virus Lytic Replication and Reactivation from Latency
... IE gene ex- pression is suppressed by the nonspecific LSD1 inhibitor TCP ...of lytic infection by multiple distinct viral patho- ...by infection with hCMV or adenovirus type ...IE ... See full document
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Herpes simplex virus type 1 latency-associated transcription unit promotes anatomical site-dependent establishment and reactivation from latency.
... A comparison of the induced reactivation frequencies of KOSM, KOS/1, KOS/29, and KOS/62 clearly demonstrates that both LATs- mutants KOS/29 and KOS/62 reactivated with a greatly reduced [r] ... See full document
13
Herpes simplex virus type 1 DNA replication and gene expression during explant-induced reactivation of latently infected murine sensory ganglia.
... i With wt, LAT-, and LAT+ rescuants of such mutants of HSV-1 strain KOSM, no significant difference in the time of appearance of infectious virus in explant cultivation of latently infec[r] ... See full document
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Herpes Simplex Virus Latency-Associated Transcript Encodes a Protein Which Greatly Enhances Virus Growth, Can Compensate for Deficiencies in Immediate-Early Gene Expression, and Is Likely To Function during Reactivation from Virus Latency
... ORF expression can completely compensate for deficien- cies in ICP0 in both BHK and ND7 cells and for VMW65 (in1814 mutant) (1) in BHK but not ND7 cells ...wild-type virus on unmanipulated ND7 ... See full document
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Temporal Association of the Herpes Simplex Virus Genome with Histone Proteins during a Lytic Infection
... the herpes simplex virus (HSV) genome during a lytic infection but that they are not arranged in an equally spaced array like in cellular ...However from 3 h to 6 h ... See full document
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