[PDF] Top 20 Fibrinogen Early In Severe Trauma studY (FEISTY): study protocol for a randomised controlled trial

... used fibrinogen can be replaced with plasma, cryoprecipitate (Cryo) and fibrinogen concentrate (FC) each containing different amounts of fibrinogen; 2 g/L, 8 – 16 g/L and 20 g/L, ...of ... See full document

... the trial centres investigators (infectious diseases phy- sicians and microbiologists) of its safe ...the study drug (day 3 and day 10), which is more frequent than recommended by UK guidelines when using ... See full document

... congenital fibrinogen deficiencies indicate that only levels below 1 g/l cause an increase in bleeding during surgery [6], and this level has generally been adopted as a target for substitution in bleeding ... See full document

... Children with sickle cell disease (SCD) frequently and unpredictably present to the emergency department (ED) [1]. In these children, pain is a common experi- ence, beginning as early as 4 to 6 months of age [2]. ... See full document

... most severe mental disorders with first clinical signs and symptoms frequently appearing in adolescence and early ...the early stages of potentially developing BD, many adolescents and young adults ... See full document

... with early cessation of breastfeeding and, if severe, may lead to unwarranted hospital admissions for treatment of abscess often requiring treatment with ...This trial seeks to provide evidence for ... See full document

... or severe dehydra- tion can seem relatively unaffected, and the acute condi- tion is often only identified by the affected vital parameters ...A study of 126 deaths among English children showed that 89 ... See full document

... the study allows for an examination of whether child or family-focused interventions are asso- ciated with greater improvements, which to date, has not been evaluated in a systematic way with children and ... See full document

... the study allows for an examination of whether child or family-focused interventions are asso- ciated with greater improvements, which to date, has not been evaluated in a systematic way with children and ... See full document

... replace fibrinogen to levels nor- mally associated with delivery with FFP because the con- centration of fibrinogen in FFP is less than 4 ...system. Fibrinogen concen- trate (RiaSTAP® manufactured by ... See full document

... PPH is a potentially life-threatening acute condition and, therefore, usually not suitable for trial inclusion according to Danish laws and regulations. This could lead to selection bias, as it may be difficult to ... See full document

... prospective trial in France pointed out that thrombocytopenia was an early prognostic indicator for sepsis patients, and the occurrence and duration ... See full document

... mised controlled trial of antenatal screening and treat- ment for bacterial vaginosis, candidiasis and/or trichomoniasis in early pregnancy (15-19 weeks gesta- tion) among over 4 000 asymptomatic ... See full document

... It is estimated that roughly 30% of the world’s refugees suffer from post-traumatic stress disorder (PTSD) and often of a more chronic form, compared to other popula- tions suffering from PTSD [2–4]. Refugees are a ... See full document

... current study is important, since consumption more than four drinks on a single occasion more than doubles the relative risk of an injury in the next 6 hours ...current study, data from the AUDIT-C are also ... See full document

... the trial is ...the trial demonstrates one detoxification agent is significantly more efficacious than ...a randomised controlled trial in the prison setting will be enormously ... See full document

... The trial will be conducted in compliance with the principles of the Declaration of Helsinki (1996), the principles of GCP and in accordance with all applicable regulatory requirements in ...The trial is ... See full document

... the trial is ...the trial demonstrates one detoxification agent is significantly more efficacious than ...a randomised controlled trial in the prison setting will be enormously ... See full document

... The number of births (count) and primary outcome will be tabulated by step (0 to 5) and by Unit. The primary out- come will be plotted for each Unit as well as globally for all Units to explore patterns visually. The ... See full document

... All analyses will be carried out using the intention-to- treat principle with data from all participants enrolled in the study. The statistical software SAS version 9.4 will be used. Descriptive statistics for ... See full document