[PDF] Top 20 Formulation and Evaluation of Extended-Release Solid Dispersion of Metformin Hydrochloride

... The release data of selected SDs were examined according to the zero-order, first-order and Higuchi’s square root of time mathematical models, Hixson and Crowell powder dissolution method and Korsmeyer and Peppas ... See full document

... was formulation development and evaluation bi-layer floating tablets for metformin hydrochloride and glimepiride to improve the oral therapeutic efficacy Both these drugs exhibit pH dependent ... See full document

... The evaluation studies concluded that higher the concentration of cholesterol (phospholipid: cholesterol = 6: 4) rigidity of the bilayer will be more and showed better controlled release of Metformin ... See full document

... India). FORMULATION AND EVALUATION OF EXTENDED RELEASE DOSAGE FORM OF METFORMIN HYDROCHLORIDE USING A COMBINED HYDROPHOBIC AND HYDOPHILIC MATRIX: RATE OF IN-VITRO AND IN-VIVO ... See full document

... involves formulation and evaluation of sustained release tablets of metformin hydrochloride which is BCS Class-III drug, using polyelectrolyte complexes of gum ...pre formulation ... See full document

... develop Metformin Hydrochloride Extended release tablets for the treatment of non-insulin-dependent diabetes mellitus (NIDDM), particularly those with refractory ...obesity. Metformin ... See full document

... the formulation development and evaluation of extended release tablets of metformin HCl, which releases the drug in a extended manner over a period of 10 ...drug release. ... See full document

... the release rate of metformin hydrochloride from all the sustained release matrix tablets was dependent on concentration of release retardant contained in the ...drug release ... See full document

... of metformin hydrochloride were successfully formulated using a swellable hydrophilic polymer (HPMC) and potassium bicarbonate for sustained drug release using wet granulation ...sustained ... See full document

... Taste evaluation of solid drug:resin complex: Drug resin complex (1:1) was subjected to sensory evaluation by a panel of nine members using time intensity ...The evaluation was performed by ... See full document

... 14) Hiremath JG et al. 25 studied the preparation and physicochemical characterization of Simvastatin loaded Mucoadhesive bilayer tablets. Tablets were prepared by direct compression technique by using mucoadhesive ... See full document

... sustained release profile over a period of 24 ...drug release were compared with standard commercial tablets ...this formulation did not alter physicochemical properties of drug, as tested by HPLC, ... See full document

... Metformin hydrochloride is an orally administered biquanide, which is widely used in the management of Type 2 diabetes, a common disease that combines defects of both insulin secretion and insulin action ... See full document

... Metformin hydrochloride has relatively short plasma half-life, low absolute ...Sustained release formulation that would maintain plasma level for 8-12 h might be sufficient for daily dosing of ... See full document

... using solid-dispersion-Sustained release matrix tablets by direct compression ...method. Solid dispersions were prepared by solvent evaporation technique using PEG 6000 poloxamer 188 and Urea ... See full document

... Sustain release formulation suitable for Metformin hydrochloride, therefore, should be a micro- encapsulation dosage form, which releases the drug slowly in the stomach for gradual absorption ... See full document

... immediate release and repeated dosing of the drug which might lead to the risk of dose fluctuation, this arises the need of a formulation with control release that maintain a near-constant or uniform ... See full document

... polymeric dispersion was applied onto nonpareil sugar spheres (18/20 mesh) using a fluid-bed spray ...The release behaviors of the coated sugar spheres were investigated in gastric fluid (pH ...14h.The ... See full document

... Tramadol Hydrochloride was obtained as a gift sample from Aurabindo Pharma, Hyderabad, ...D Extended release formulations make the drug available over extended time period after oral ...The ... See full document

... The release was then completed within the successive 2 h of elution with simulated jejunal fluid (SJF, pH ...dissolved. Release in SGF was controlled by matrix swelling and/or drug diffusion in matrix, ... See full document