[PDF] Top 20 Function and evolution of genes in the human protein interaction network
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Function and evolution of genes in the human protein interaction network
... retrograde evolution (Horowitz, ...retrograde evolution model requires an abundance of substrates, ready to be used, which is not a very likely scenario considering that many intermediate metabolites are ... See full document
166
Protein-Protein Interaction Network Alignment
... about protein complexes, pathways and modules are also very important in PPI network ...in protein functions research, they are also a vital standard to measure network alignment ...annotated ... See full document
66
New genes drive the evolution of gene interaction networks in the human and mouse genomes
... originating genes were found to be particularly shorter in protein length (Additional file 11: Figure S6A) [10], and consequently could only provide a limited interaction surface for potential ... See full document
14
Expression and evolution of the Tiki1 and Tiki2 genes in vertebrates
... the rodent Tiki1 gene (after the Lagomorph/Rodent divergence ~ 60 MYA) (Benton and Donoghue, 2007) it is possible that novel expression patterns of Tiki2 may have evolved to compensate for Tiki1 function. ... See full document
9
In Silico Analysis of the Protein Structure of Tumor Suppressor Genes in Humans
... suppressor genes encode for proteins that are involved in inhibition of cell proliferation, induction of apoptosis, DNA damage repair and inhibition of metastasis and these are crucial to normal cell development ... See full document
6
The evolution of the structure of tubulin and its potential consequences for the role and function of microtubules in cells and embryos
... tubulin genes, with each distinct tubulin isoform having an essential ...Euplotes, human, rat, Xenopus, mouse, dog and ...Chlamydomonas, human, mouse, rat, Xenopus and ...biological function ... See full document
18
Identification of genetic interaction networks via an evolutionary algorithm evolved Bayesian network
... Using main effect filtering followed by GEBN analysis, we replicated canonical associ- ations and also identified novel genetic interactions for type 2 diabetes. The most sig- nificant association was rs7903146, which is ... See full document
12
Chronic pre treatment with memantine prevents amyloid beta protein mediated long term potentiation disruption
... of interaction data from phylogenetic ...of human protein-protein interactions, showing that most such interactions appear relatively ancient, dating no later than the radiation of placental ... See full document
11
Identification of novel gene and pathway targets for human epilepsy treatment
... the protein–protein interaction (PPI) network and co- expression modules associated with ...into protein function, besides, they may help to uncover the generic organization ... See full document
9
Original Article Scree ning of hepatocellular carcinoma hub genes and construction of a control network
... threatens human life and ...differentially-expressed genes of HCC, providing a new method for diagnosis and treatment of ...differentially-expressed genes using the R program. The gene ... See full document
13
Original Article Identification of key genes associated with idiopathic pulmonary fibrosis using bioinformatics analysis
... expressed genes (DEGs) between IPF and control ...DEGs, protein-protein interactions (PPIs) were pre- dicted by STRING and PPI network was visualized by Cytoscape ...down-regulated ... See full document
9
Original Article Exploring genes of rectal cancer based on protein interaction network
... updated human phenotype database, containing more than 12000 genes of all human genetic diseas- es, and mainly focusing on hereditary ...obtained human genes associated with rectal ... See full document
18
Identification of key pathways and genes with aberrant methylation in prostate cancer using bioinformatics analysis
... metabolism-related genes are the most commonly observed epigenetic alterations in ....160 genes reported to be epigeneti- cally dysregulated, and shortlisted 26 differentially methylated genes (DMGs) ... See full document
9
Identifying the novel key genes in renal cell carcinoma by bioinformatics analysis and cell experiments
... PPI network was predicted and structured using Search Tool for the Retrieval of Interacting Genes (STRING: http://strin ...PPI network of DEGs was constructed using STRING database, and an inter- ... See full document
16
RETRACTED ARTICLE: Establishing an osteosarcoma associated protein-protein interaction network to explore the pathogenesis of osteosarcoma
... expressed genes (DEGs) between osteosarcoma and control samples were identified by packages in R with the threshold of |logFC (fold change)| > 1 and false discovery rate < ...the interaction ... See full document
7
Genomics of neonatal sepsis: has-miR-150 targeting BCL11B functions in disease progression
... expressed genes (DEGs) were analyzed by the Bayesian testing method in limma ...software, protein-protein interaction (PPI) network and module analyses were ...regulatory network ... See full document
7
Construction and analysis of protein-protein interaction network associated with human sperm-egg interaction
... constructing protein interaction networks, utilizing genomic and protein sequence information contain a study of the absence or presence of genes in associated species, co-occurrence of ... See full document
44
Integrated bioinformatic analysis unveils significant genes and pathways in the pathogenesis of supratentorial primitive neuroectodermal tumor
... expressed genes (DEGs) were screened out in primary sPNET samples compared with normal fetal and adult brain reference samples (sPNET vs fetal brain and sPNET vs adult ...by protein–protein ... See full document
11
De novo deletions and duplications of 17q25.3 cause susceptibility to cardiovascular malformations
... according to the manufacturers’ instructions. Seven of the eight subjects were studied with custom-designed genome-wide array with approximately 180,000 oligo- nucleotides, manufactured by Agilent Technologies, Inc. ... See full document
9
Evolution of function in protein superfamilies
... Later, Yeas (1974) and Jensen (1976) proposed an altern ativ e to H orow itz’s theory of pathw ay developm ent, now referred to as th e ‘patchw ork evolution’ m odel. In earlier system s, there were fewer enzymes ... See full document
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