[PDF] Top 20 Function and regulation of Platelet-Derived Growth Factor Receptor Alpha during development
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Function and regulation of Platelet-Derived Growth Factor Receptor Alpha during development
... transcriptional regulation of the PDGFRa gene, I analyzed the relative promoter activities o f a 6 kb upstream fragment of the murine PDGFRa promoter and a ...a regulation, particularly in OLPs, I generated ... See full document
224
Regulation and function of the tissue specific transcription factor HNF1 alpha (LFB1) during Xenopus development
... Int J De,' lIiol ~O 297 304 (t996) Regulation and function of the tissue specific transcription factor HNF1a (LFB1) during Xenopus development HElKE WEBER, ELKE POGGE V STRANDMANN, BEATRIX HOLEWA, SIG[.] ... See full document
8
Platelet-derived growth factor and its receptors in retinal development
... acids, term ed src homology 2 dom ains (SH2). These are recognition m otifs for specific tyrosine-phosphorylated peptide sequences. SH2 dom ains are usually accom panied by a n o th e r conserved dom ain of 50 am ino ... See full document
191
Platelet derived growth factor receptor alpha mediates nodal metastases in papillary thyroid cancer by driving the epithelial- mesenchymal transition
... We further characterise the PDGFRα-induced protrusions as functional invadopodia, as judged by their gelatinase activity. The assessment of invadopodia- mediated ECM degradation by microscopy using fluorescently-labeled ... See full document
17
Immunolocalization of platelet‐derived growth factor receptor‐β (PDGFR‐β) and pericytes in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL)
... signals during angiogenesis and some phagocytic ...and during ischaemia ...populations during angiogenesis: transforming growth factor-β, angiopoietin and platelet-derived ... See full document
14
Structural analysis of platelet-derived growth factor receptor alpha by protein homology modeling
... Human receptor tyrosine kinases (RTKs) and their ligands are important regulators of intracellular signal transduction pathways mediating various processes at cellular ...cell growth and migration (Lemmon ... See full document
25
Olaratumab: a platelet-derived growth factor receptor-α-blocking antibody for the treatment of soft tissue sarcoma
... Grade 3/4 adverse events occurred more frequently in the doxorubicin and olaratumab arm (38/42%) than the doxorubicin- alone arm (38/31%), and doxorubicin-associated adverse events were more frequent in the combination ... See full document
6
Modulation of platelet derived growth factor receptor expression in microvascular endothelial cells during in vitro angiogenesis
... microvascular endothelial cells expressed both PDGF receptor alpha and beta chains. Suramin treatment demonstrated continuous downregulation of the alpha receptor surface expression. PDGF BB ... See full document
10
Effects of platelet derived growth factor and other polypeptide mitogens on DNA synthesis and growth of cultured rat liver fat storing cells
... the development of liver fibrosis. We explored the effects of platelet-derived growth factor (PDGF), epidermal growth factor (EGF), transforming growth ... See full document
9
Molecular structure and transcriptional regulation of the gene for the platelet derived growth factor alpha receptor in cultured vascular smooth muscle cells
... PDGF has been shown to contribute to hypertrophy in vascular smooth muscle cells (VSMC). PDGF-AA differentially promotes protein synthesis in VSMC from spontaneously hypertensive rats (SHR) but not in those from ... See full document
11
Olaratumab in soft tissue sarcoma - Current status and future perspectives.
... against platelet-derived growth factor receptor alpha (PDGFR a ), to doxorubicin confers an unprecedented improvement in overall survival to pa- tients with anthracycline-naı¨ve ... See full document
7
Coupling of LETM1 up-regulation with oxidative phosphorylation and platelet-derived growth factor receptor signaling via YAP1 transactivation
... glycolysis, also called the “Warburg effect”, drives metabolic remodeling in PTEN-deficient thyroid cells [9]. Crosstalk between oncogenic BRAFV600E kinase and the mitochondria also increases glycolytic activity in ... See full document
12
Regional expression of the platelet derived growth factor and its receptors in a primate graft model of vessel wall assembly
... PDGF receptor beta-subunit mRNA and protein were easily detectable in the neointima and graft ...PDGF receptor alpha-subunit mRNA was also observed in the graft matrix and at lower levels in the ... See full document
12
PDGF/PDGFR effects in osteosarcoma and the “add-on” strategy
... The platelet-derived growth factor (PDGF)/platelet-derived growth factor receptor (PDGFR) pathway plays an important role in the development and ... See full document
9
Antiangiogenic effects in patients with progressive desmoplastic small round cell tumor: data from the French national registry dedicated to the use of off-labeled targeted therapy in sarcoma (OUTC’s)
... endothelial growth factor receptors (VEGFR) 1–3, c-KIT, and the platelet-derived growth factor receptors (PDGFR) alpha and beta, and has been approved for advanced soft ... See full document
7
Original Article The overexpression of PDGF-BB and its receptor is correlated with lymphatic metastasis in patients with non-small cell lung cancer
... prognostic factor for human ...multiple growth factors. Platelet-derived growth factor-BB (PDGF-BB) and platelet-derived growth factor ... See full document
8
Selective deletion of hepatocyte platelet-derived growth factor receptor α and development of liver fibrosis in mice
... Male 8-week old C57BL/6 (WT) and PDGFRα condi- tional KO mice (PDGFRα KO) were used. The animals were housed with a 12 h light:dark cycle and fed standard chow. For the fibrosis groups, thioacetamide (TAA) (300 mg/kg ... See full document
11
Excessive activation of the TLR9/TGF β1/PDGF B pathway in the peripheral blood of patients with systemic lupus erythematosus
... Increased levels of TLR9, TGF-β1, and PDGF-B in SLE patients indicate the upregulation of this pathway. We further explored the possible involvement of this pathway in the pathogenesis of glomerulonephritis. We found ... See full document
12
Anti-VEGF agents in metastatic colorectal cancer (mCRC): are they all alike?
... endothelial growth factor (VEGF)-A, a key player in the angiogenesis ...placental growth factor, which could enable escape from VEGF-A-targeted angiogenesis ... See full document
13
The role of platelet derived growth factor in the development of mouse molars
... Int J De, MiDI 39 939 945 (1995) 939 Original Arlie/I' The role of platelet derived growth factor in the development of mouse molars JAN CoCo HU", CHUHUA ZHANG' and HAROLD C SLAVKIN2 IDepartment of Pe[.] ... See full document
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