[PDF] Top 20 Functional Analysis of the Human Antibody Response to Meningococcal Factor H Binding Protein
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Functional Analysis of the Human Antibody Response to Meningococcal Factor H Binding Protein
... Three human subjects were immunized in Krakow, Poland, in a study sponsored by Novartis Vaccine, using two doses of multicomponent serogroup B meningococcal vaccines contain- ing recombinant FHbp ID 1 (9, ... See full document
11
A Critical Threshold of Meningococcal Factor H Binding Protein Expression Is Required for Increased Breadth of Protective Antibodies Elicited by Native Outer Membrane Vesicle Vaccines
... bactericidal antibody response was directed against LOS, with only a minor contribution of anti-fHbp ...anti-fHbp antibody responses to the Keiser vaccine, since by Western blotting the recombinant ... See full document
7
Anti-Factor H Antibody Reactivity in Young Adults Vaccinated with a Meningococcal Serogroup B Vaccine Containing Factor H Binding Protein
... other meningococcal vaccines that did not contain re- combinant FHbp (P ⫽ ...host response to ...anti-FH antibody levels did not impair serum FH function as measured using a he- molytic ... See full document
14
Heterogeneity in Rhesus Macaque Complement Factor H Binding to Meningococcal Factor H Binding Protein (FHbp) Informs Selection of Primates To Assess Immunogenicity of FHbp-Based Vaccines
... downregulator factor H (FH) to the bacterial ...studies, binding of FH to one of the major meningococcal FH ligands, factor H binding protein (FHbp), was reported ... See full document
7
Cloning, expression and purification of the factor H binding protein and its interaction with factor H
... virulence factor in vivo, but also it can be as a target antigen for vaccination against ...fH binding to the bacteria to increase the susceptibility of the bacterium to be killed by the alternative ... See full document
7
Functional analysis of a murine monoclonal antibody against the repetitive region of the fibronectin binding adhesins fibronectin binding protein A and fibronectin binding protein B from Staphylococcus aureus
... the analysis to ...ELISA binding assay in which the reactiv- ities of the FnBRs from FnBPA and FnBPB for intact Fn were ...low-affinity binding sites in the remaining ...Dose–response ... See full document
16
Functional analysis of the Rac-binding protein POSH
... P]), via residues 5-80 [Beck, 1991] [Gaidarov, 1996]. This lipid-binding site is close to a region of the a subunit implicated in membrane targeting of AP2 [Page, 1995]. Work by West et al provided further ... See full document
291
Localization of the binding regions of a murine monoclonal anti factor VIII antibody and a human anti factor VIII alloantibody, both of which inhibit factor VIII procoagulant activity, to amino acid residues threonine351 serine365 of the factor VIII heavy chain
... A human FVIII inhibitor (anti-FVIII heavy chain alloantibody) was also partially neutralized by ...activated protein C cleavage site (Arg336) and may be at or near a region of functional importance ... See full document
7
Molecular Engineering of Ghfp, the Gonococcal Orthologue of Neisseria meningitidis Factor H Binding Protein
... to human neural antigens, which has raised con- cerns about the risk of inducing autoreactive antibodies ...two protein-based vaccines approved for use in humans, one (Trumenba) licensed in the United ... See full document
9
Human Factor H (FH) Impairs Protective Meningococcal Anti FHbp Antibody Responses and the Antibodies Enhance FH Binding
... of human FH on decreasing serum anti-FHbp bac- tericidal antibody responses in the 4CMenB-vaccinated Tg mice appeared to be disproportionately greater than the decrease in IgG anti-FHbp antibody ... See full document
9
Enhanced protective antibody to a mutant meningococcal factor H-binding protein with low-factor H binding
... inhibit binding of FH to ...inhibited binding of human FH to FHbp on the bacterial surface (12, ...inhibit binding of FH to meningococci (16, 17, ...inhibit binding of FH to live ... See full document
14
Does Binding of Complement Factor H to the Meningococcal Vaccine Antigen, Factor H Binding Protein, Decrease Protective Serum Antibody Responses?
... fH binding to fHbp in variant group 1, did not affect fH binding to fHbps in variant group 2 ...decreased binding of fH ...in human fH transgenic mice. Again, we excluded mice with serum ... See full document
9
Impaired Immunogenicity of a Meningococcal Factor H-Binding Protein Vaccine Engineered To Eliminate Factor H Binding
... Meningococcal factor H-binding protein (fHbp) is a promising antigen that is part of two vaccines in clinical ...The protein specifically binds human complement ... See full document
5
Bioboosters in the treatment of rheumatic diseases: a comprehensive review of currently available biologics in patients with rheumatoid arthritis, ankylosing spondylitis and psoriatic arthritis
... Even if the need for combined therapy with MTX to achieve a significant beneficial effect on clinical signs and symptoms of RA seems to overshadow the decisive therapeutic role of anti-TNF drugs, the evidence supports ... See full document
16
Characterization of Txndc5 as a Biomarker of Humoral Immunity to Respiratory Syncytial Virus Infections in Infants in Kilifi County Kenya
... Respiratory syncytial virus (RSV) is a major cause of lower respiratory tract infection (LRTI) in children worldwide (Nair et al., 2010) as well as in older individuals with cardiopulmonary disease or in whom immune ... See full document
103
Meningococcal phenotypic and genotypic characteristics and human antibody levels
... The aim of the present investigation was to study the meningococcal carrier rate and the levels of antimeningococcal immunoglobulin G IgG antibodies in a healthy population, to character[r] ... See full document
5
Identification of human T-cell lymphotropic virus type I 21-base-pair repeat-specific and glial cell-specific DNA-protein complexes.
... Competition EMS analyses with oligonucleotides containing transcription factor binding site sequences indicate the involvement of a cyclic AMP response element binding protein in the for[r] ... See full document
12
Follicular fluid biomarkers for human in vitro fertilization outcome: Proof of principle
... compared protein patterns in FF from immature and mature FF using two-dimensional gel electrophoresis (2-DE) [27], reporting considerable diffe- rences in protein patterns derived from fluids of immature ... See full document
11
Long-term use of adalimumab in the treatment of rheumatic diseases
... Spondylitis Functional Index (BASFI) score and inflammation, represented by the mean of the severity and duration of morning stiffness], Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), ... See full document
18
Characterization of an acquired inhibitor to coagulation factor V Antibody binding to the second C type domain of factor V inhibits the binding of factor V to phosphatidylserine and neutralizes procoagulant activity
... IgG antibody that bound to the light chain of Factor ...this antibody binds to the second C-type domain of the light ...of Factor Va, implying that the neutralization resulted from specific ... See full document
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